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Department News

Brittany Butler awarded Graduate Student Poster Presentation Award

Congratulations to Brittany Butler, a fourth year doctoral candidate in the Neuroscience concentration within the IDP program at the University of Florida.  She is a senior graduate student in the laboratory of Dr. Habibeh Khoshbouei, where her dissertation research seeks to investigate the influence of alpha-synuclein overexpression on…

Dr. Yong Ran and lab publish in Feb 2014 Journal of Biological Chemistry

“gamma-Secretase Processing and Effects of gamma-Secretase Inhibitors and Modulators on Long Abeta Peptides in Cells” Ran Y, Cruz PE, Ladd TB, Fauq AH, Jung JI, Matthews J, Felsenstein KM, Golde TE.  J Biol Chem 2014; 289(6):3276-3287. Abstract Understanding how different species of Aβ are generated by γ-secretase cleavage…

Drs. Felsenstein & Golde publish in March 2014 Biochemistry

“Complex Relationships between Substrate Sequence and Sensitivity to Alterations in gamma-Secretase Processivity Induced by gamma-Secretase Modulators” Jung JI, Ran Y, Cruz PE, Rosario AM, Ladd TB, Kukar TL, Koo EH, Felsenstein KM, Golde TE.  Biochemistry 2014. Abstract γ-Secretase catalyzes the final cleavage of the amyloid precursor protein…

Dr. Todd Golde publishes in Feb 2014 Frontiers in Immunology

“Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells” Dongre A, Surampudi L, Lawlor RG, Fauq AH, Miele L, Golde TE, Minter LM, Osborne BA.  Front Immunol 2014; 5:54. Abstract Cleavage of the Notch receptor via a γ-secretase, results in the release of the active…

Dr. Todd Golde & colleagues publish in March 2014 Journal of Neuroscience

“Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer’s Disease” Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, Noebels JL, Jankowsky JL.  J Neurosci 2014; 34(11):3826-3840. Abstract Alzheimer’s…