Molecular aspects of age-related cognitive decline: the role of GABA signaling. McQuail JA, Frazier CJ, Bizon JL. Trends Mol Med 2015. Abstract: Alterations in inhibitory interneurons contribute to cognitive deficits associated with several psychiatric and neurological diseases. Phasic and tonic inhibition imparted by γ-aminobutyric acid…
Investigation of the subcellular architecture of L7 neurons of Aplysia californica using magnetic resonance microscopy (MRM) at 7.8 microns. Lee CH, Flint JJ, Hansen B, Blackband SJ. Sci Rep 2015; 5:11147. Abstract: Magnetic resonance microscopy (MRM) is a non-invasive diagnostic tool which is well-suited to directly resolve…
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Dopamine Transporter Activity Is Modulated by alpha-synuclein. Butler B, Goodwin S, Saha K, Becker J, Sambo D, Davari P, Khoshbouei H. J Biol Chem 2015. Abstract: The duration and strength of the dopaminergic signal is regulated by the dopamine transporter (DAT). Drug addiction, neurodegenerative and neuropsychiatric diseases…
Differential Inhibition of Signal Peptide Peptidase Family Members by Established gamma-Secretase Inhibitors. Ran Y, Ladd GZ, Ceballos-Diaz C, Jung JI, Greenbaum D, Felsenstein KM, Golde TE. PLoS One 2015; 10(6):e0128619. Abstract: The signal peptide peptidases (SPPs) are biomedically important proteases implicated as therapeutic targets for hepatitis C…
Characterization of Protein Structural Changes in Living Cells Using Time-Lapsed FTIR Imaging. Gelfand P, Smith RJ, Stavitski E, Borchelt DR, Miller LM. Anal Chem 2015. Abstract: Fourier-transform infrared (FTIR) spectroscopic imaging is a widely used method for studying the chemistry of proteins, lipids, and DNA in…
Substantially elevating the levels of alphaB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation. Xu G, Fromholt S, Ayers JI, Brown H, Siemienski Z, Crosby KW, Mayer CA, Janus C, Borchelt DR. J Neurochem 2015; 133(3):452-464. Abstract:…
Molecular Evidence for Convergence and Parallelism in Evolution of Complex Brains of Cephalopod Molluscs: Insights from Visual Systems. Yoshida MA, Ogura A, Ikeo K, Shigeno S, Moritaki T, Winters GC, Kohn AB, Moroz LL. Integr Comp Biol 2015. Abstract: Coleoid cephalopods show remarkable evolutionary convergence with vertebrates…
Intermittent Hypoxia and Neurorehabilitation. Gonzalez-Rothi EJ, Lee KZ, Dale EA, Reier PJ, Mitchell GS, Fuller DD. J Appl Physiol 2015;jap. Abstract: In recent years, it has become clear that brief, repeated presentations of hypoxia (i.e., acute intermittent hypoxia, AIH) can boost the efficacy of more traditional therapeutic…
