The effects of GABA and NMDA receptors in the shell-accumbens on spatial memory of METH-treated rats. Heysieattalab S, Naghdi N, Zarrindast MR, Haghparast A, Mehr SE, Khoshbouei H. Pharmacol Biochem Behav 2015. Abstract: Methamphetamine (METH) is a highly addictive and neurotoxic psychostimulant. Its use in humans is…
Congratulations to graduate students Sofia Beas, Jeffrey Fortin, and Kim Hawkins, who all successfully defended their dissertations and graduated in December 2015. Sofia Beas (Mentor: Dr. Jennifer Bizon): The Role of Cortical Inhibition in Age-Related Executive Function Decline Jeffrey Fortin (Mentor: Dr. Brent Reynolds): Transplantation of Defined Populations of Differentiated…
gamma-Secretase Modulators and APH1 Isoforms Modulate gamma-Secretase Cleavage but Not Position of epsilon-Cleavage of the Amyloid Precursor Protein (APP). Lessard CB, Cottrell BA, Maruyama H, Suresh S, Golde TE, Koo EH. PLoS One 2015; 10(12):e0144758. Abstract: The relative increase in Aβ42 peptides from familial Alzheimer disease (FAD)…
Molecular Evidence for Convergence and Parallelism in Evolution of Complex Brains of Cephalopod Molluscs: Insights from Visual Systems. Yoshida MA, Ogura A, Ikeo K, Shigeno S, Moritaki T, Winters GC, Kohn AB, Moroz LL. Integr Comp Biol 2015; 55(6):1070-1083. Abstract: Coleoid cephalopods show remarkable evolutionary convergence with…
Parallel Evolution and Lineage-Specific Expansion of RNA Editing in Ctenophores. Kohn AB, Sanford RS, Yoshida MA, Moroz LL. Integr Comp Biol 2015; 55(6):1111-1120. Abstract: RNA editing is a process of targeted alterations of nucleotides in all types of RNA molecules (e.g., rRNA, tRNA, mRNA, and miRNA). As…
DNA Methylation in Basal Metazoans: Insights from Ctenophores. Dabe EC, Sanford RS, Kohn AB, Bobkova Y, Moroz LL. Integr Comp Biol 2015; 55(6):1096-1110. Abstract: Epigenetic modifications control gene expression without altering the primary DNA sequence. However, little is known about DNA methylation in invertebrates and its evolution.
Biodiversity Meets Neuroscience: From the Sequencing Ship (Ship-Seq) to Deciphering Parallel Evolution of Neural Systems in Omic’s Era. Moroz LL. Integr Comp Biol 2015; 55(6):1005-1017. Abstract: The origins of neural systems and centralized brains are one of the major transitions in evolution. These events might occur more…
A Microperfusion and In-Bore Oxygenator System Designed for Magnetic Resonance Microscopy Studies on Living Tissue Explants. Flint JJ, Menon K, Hansen B, Forder J, Blackband SJ. Sci Rep 2015; 5:18095. Abstract: Spectrometers now offer the field strengths necessary to visualize mammalian cells but were not designed to…
Unbiased View of Synaptic and Neuronal Gene Complement in Ctenophores: Are There Pan-neuronal and Pan-synaptic Genes across Metazoa? Moroz LL, Kohn AB. Integr Comp Biol 2015; 55(6):1028-1049. Abstract: Hypotheses of origins and evolution of neurons and synapses are controversial, mostly due to limited comparative data. Here, we…
Hyperpolarization-activated, cyclic nucleotide-gated cation channels in Aplysia: Contribution to classical conditioning. Yang Q, Kuzyk P, Antonov I, Bostwick CJ, Kohn AB, Moroz LL, Hawkins RD. Proc Natl Acad Sci U S A 2015. Abstract: Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels are critical regulators of neuronal excitability, but…
