Non-prion-type transmission in A53T alpha-synuclein transgenic mice: a normal component of spinal homogenates from naive non-transgenic mice induces robust alpha-synuclein pathology. Sacino AN, Ayers JI, Brooks MM, Chakrabarty P, Hudson VJ, III, Howard JK, Golde TE, Giasson BI, Borchelt DR. Acta Neuropathol 2016; 131(1):151-154.
Independent origins of neurons and synapses: insights from ctenophores. Moroz LL, Kohn AB. Philos Trans R Soc Lond B Biol Sci 2016; 371(1685). Abstract: There is more than one way to develop neuronal complexity, and animals frequently use different molecular toolkits to achieve similar functional outcomes. Genomics…
Development of neuromuscular organization in the ctenophore Pleurobrachia bachei. Norekian TP, Moroz LL. J Comp Neurol 2016; 524(1):136-151. Abstract: The phylogenetic position of the phylum Ctenophora and the nature of ctenphore nervous systems are highly debated topics in modern evolutionary biology. However, very little is known about…
Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies. Lewis J, Dickson DW. Acta Neuropathol 2016; 131(1):27-48. Abstract: Tau is a microtubule-associated protein and a key regulator of microtubule stabilization as well as the main component of neurofibrillary tangles-a principle…
Propagation of Abeta, tau and alpha-synuclein pathology between experimental models and human reality: prions, propagons and propaganda. Uchihara T, Giasson BI, Paulus W. Acta Neuropathol 2016; 131(1):1-3. Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies. Uchihara T,…
The effects of GABA and NMDA receptors in the shell-accumbens on spatial memory of METH-treated rats. Heysieattalab S, Naghdi N, Zarrindast MR, Haghparast A, Mehr SE, Khoshbouei H. Pharmacol Biochem Behav 2015. Abstract: Methamphetamine (METH) is a highly addictive and neurotoxic psychostimulant. Its use in humans is…
Congratulations to graduate students Sofia Beas, Jeffrey Fortin, and Kim Hawkins, who all successfully defended their dissertations and graduated in December 2015. Sofia Beas (Mentor: Dr. Jennifer Bizon): The Role of Cortical Inhibition in Age-Related Executive Function Decline Jeffrey Fortin (Mentor: Dr. Brent Reynolds): Transplantation of Defined Populations of Differentiated…
gamma-Secretase Modulators and APH1 Isoforms Modulate gamma-Secretase Cleavage but Not Position of epsilon-Cleavage of the Amyloid Precursor Protein (APP). Lessard CB, Cottrell BA, Maruyama H, Suresh S, Golde TE, Koo EH. PLoS One 2015; 10(12):e0144758. Abstract: The relative increase in Aβ42 peptides from familial Alzheimer disease (FAD)…
Molecular Evidence for Convergence and Parallelism in Evolution of Complex Brains of Cephalopod Molluscs: Insights from Visual Systems. Yoshida MA, Ogura A, Ikeo K, Shigeno S, Moritaki T, Winters GC, Kohn AB, Moroz LL. Integr Comp Biol 2015; 55(6):1070-1083. Abstract: Coleoid cephalopods show remarkable evolutionary convergence with…
Parallel Evolution and Lineage-Specific Expansion of RNA Editing in Ctenophores. Kohn AB, Sanford RS, Yoshida MA, Moroz LL. Integr Comp Biol 2015; 55(6):1111-1120. Abstract: RNA editing is a process of targeted alterations of nucleotides in all types of RNA molecules (e.g., rRNA, tRNA, mRNA, and miRNA). As…
