Ashok Kumar

Ashok Kumar,

Research Associate Professor

Department: Department of Neuroscience
Business Phone: (352) 392-4085
Business Email: kash@ufl.edu

Teaching Profile

Courses Taught
2016-2020
GMS6592 Ion Channels Journal Club: Pharmacology, Biophysics, and Neuroscience of Excitable Membranes
2008
EML5526 Finite Elem Analysis

Publications

2020
Calcium Signaling During Brain Aging and Its Influence on the Hippocampal Synaptic Plasticity.
Advances in experimental medicine and biology. 1131:985-1012 [DOI] 10.1007/978-3-030-12457-1_39. [PMID] 31646542.
2019
Behavior Model for Assessing Decline in Executive Function During Aging and Neurodegenerative Diseases.
Methods in molecular biology (Clifton, N.J.). 2011:441-449 [DOI] 10.1007/978-1-4939-9554-7_26. [PMID] 31273715.
2018
Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension.
Hypertension. 71(6):1156-1163 [DOI] 10.1161/HYPERTENSIONAHA.118.10934. [PMID] 29712738.
2018
Measurement of Prompt D^{0} Meson Azimuthal Anisotropy in Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.
Physical Review Letters. 120(20) [DOI] 10.1103/PhysRevLett.120.202301. [PMID] 29864330.
2018
Measurements of the Pp -> Zz Production Cross Section and the Z -> 4L Branching Fraction, and Constraints on Anomalous Triple Gauge Couplings at Root S=13Tev
The European physical journal. C, Particles and fields. 78(2) [DOI] 10.1140/epjc/s10052-018-5567-9. [PMID] 30996656.
2018
Nonsteroidal anti-inflammatory drug, indomethacin improves spatial memory and NMDA receptor function in aged animals.
Neurobiology of aging. 70:184-193 [DOI] 10.1016/j.neurobiolaging.2018.06.026. [PMID] 30031231.
2018
NS6740, an α7 nicotinic acetylcholine receptor silent agonist, disrupts hippocampal synaptic plasticity.
Neuroscience letters. 677:6-13 [DOI] 10.1016/j.neulet.2018.04.025. [PMID] 29679680.
2018
Observation of (Tt)Over-Barh Production
Physical Review Letters. 120(23) [DOI] 10.1103/PhysRevLett.120.231801. [PMID] 29932697.
2018
Search for Heavy Neutral Leptons in Events With Three Charged Leptons in Proton-Proton Collisions at Root S=13 Tev
Physical Review Letters. 120(22) [DOI] 10.1103/PhysRevLett.120.221801.
2018
Search for Narrow Resonances in the B-Tagged Dijet Mass Spectrum in Proton-Proton Collisions at Root S=8 Tev
Physical Review Letters. 120(20) [DOI] 10.1103/PhysRevLett.120.201801. [PMID] 29864370.
2018
Search for the Pair Production of Third-Generation Squarks With Two-Body Decays to a Bottom or Charm Quark and a Neutralino in Proton-Proton Collisions at Root S=13 Tev
Physics Letters B. 778:263-291 [DOI] 10.1016/j.physletb.2018.01.012.
2018
Search for the X(5568) State Decaying Into B-S(0)Pi(+/-) in Proton-Proton Collisions at Root S=8 Tev
Physical Review Letters. 120(20) [DOI] 10.1103/PhysRevLett.120.202005. [PMID] 29864318.
2018
The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury.
Frontiers in physiology. 9 [DOI] 10.3389/fphys.2018.00180. [PMID] 29636695.
2015
Impaired attention and synaptic senescence of the prefrontal cortex involves redox regulation of NMDA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(9):3966-77 [DOI] 10.1523/JNEUROSCI.3523-14.2015. [PMID] 25740525.
2015
Re-Opening the Critical Window for Estrogen Therapy.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(49):16077-93 [DOI] 10.1523/JNEUROSCI.1890-15.2015. [PMID] 26658861.
2014
Assessing the Emergence and Reliability of Cognitive Decline Over the Life Span in Fisher 344 Rats Using the Spatial Water Maze
Frontiers in Aging Neuroscience. 6 [DOI] 10.3389/fnagi.2014.00002. [PMID] 24478698.
2014
Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses.
Hippocampus. 24(4):466-75 [DOI] 10.1002/hipo.22240. [PMID] 24390964.
2014
Role of antioxidant enzymes in redox regulation of N-methyl-D-aspartate receptor function and memory in middle-aged rats.
Neurobiology of aging. 35(6):1459-68 [DOI] 10.1016/j.neurobiolaging.2013.12.002. [PMID] 24388786.
2013
Daily exercise improves memory, stimulates hippocampal neurogenesis and modulates immune and neuroimmune cytokines in aging rats.
Brain, behavior, and immunity. 28:25-43 [DOI] 10.1016/j.bbi.2012.09.013. [PMID] 23078985.
2013
Environmental enrichment restores neurogenesis and rapid acquisition in aged rats.
Neurobiology of aging. 34(1):263-74 [DOI] 10.1016/j.neurobiolaging.2012.05.023. [PMID] 22795793.
2013
Linking redox regulation of NMDAR synaptic function to cognitive decline during aging.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(40):15710-5 [DOI] 10.1523/JNEUROSCI.2176-13.2013. [PMID] 24089479.
2013
Memory in Aged Mice Is Rescued By Enhanced Expression of the Glun2B Subunit of the Nmda Receptor
Behavioural brain research. 238:211-226 [DOI] 10.1016/j.bbr.2012.10.026. [PMID] 23103326.
2013
Role of estrogen receptor α and β in preserving hippocampal function during aging.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(6):2671-83 [DOI] 10.1523/JNEUROSCI.4937-12.2013. [PMID] 23392694.
2012
Enhanced Expression of Pctk1, Tcf12 and Ccnd1 in Hippocampus of Rats: Impact On Cognitive Function, Synaptic Plasticity and Pathology
Neurobiology of Learning and Memory. 97(1):69-80 [DOI] 10.1016/j.nlm.2011.09.006. [PMID] 21982980.
2012
Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology.
Neurobiology of aging. 33(4):828.e1-17 [DOI] 10.1016/j.neurobiolaging.2011.06.023. [PMID] 21820213.
2012
Influence of Viral Vector-Mediated Delivery of Superoxide Dismutase and Catalase To the Hippocampus On Spatial Learning and Memory During Aging
Antioxidants & Redox Signaling. 16(4):339-350 [DOI] 10.1089/ars.2011.4054. [PMID] 21942371.
2012
Similarities and Dissimilarities of Two Experimental Models of Tbi (Closed Head and Blast Tbi) in Long-Term Disabilities: Spasticity, Cognitive and Synaptic Function, Balance, Anxiety, and Pain Related Behaviors
Journal of Neurotrauma. 29:A56-A57
2010
Carbachol-induced long-term synaptic depression is enhanced during senescence at hippocampal CA3-CA1 synapses.
Journal of neurophysiology. 104(2):607-16 [DOI] 10.1152/jn.00278.2010. [PMID] 20505129.
2010
Flagellin-induced corneal antimicrobial peptide production and wound repair involve a novel NF-kappaB-independent and EGFR-dependent pathway.
PloS one. 5(2) [DOI] 10.1371/journal.pone.0009351. [PMID] 20195469.
2010
Intracellular Redox State Alters Nmda Receptor Response During Aging Through Ca(2+)/Calmodulin-Dependent Protein Kinase II
The Journal of Neuroscience. 30(5):1914-1924 [DOI] 10.1523/JNEUROSCI.5485-09.2010. [PMID] 20130200.
2010
PHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus.
Journal of neurochemistry. 115(4):941-55 [DOI] 10.1111/j.1471-4159.2010.06984.x. [PMID] 20819118.
2009
Estrogen effects on cognition and hippocampal transcription in middle-aged mice.
Neurobiology of aging. 30(6):932-45 [PMID] 17950954.
2009
Fragile X mental retardation protein replacement restores hippocampal synaptic function in a mouse model of fragile X syndrome.
Gene therapy. 16(9):1122-9 [DOI] 10.1038/gt.2009.83. [PMID] 19571888.
2009
Regional Hippocampal Differences in Akt Survival Signaling Across the Lifespan: Implications for Ca1 Vulnerability With Aging
Cell Death and Differentiation. 16(3):439-448 [DOI] 10.1038/cdd.2008.171. [PMID] 19039330.
2008
AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation.
Investigative ophthalmology & visual science. 49(10):4278-83 [DOI] 10.1167/iovs.07-1622. [PMID] 18586879.
2008
Viral vector-mediated delivery of estrogen receptor-alpha to the hippocampus improves spatial learning in estrogen receptor-alpha knockout mice.
Molecular therapy : the journal of the American Society of Gene Therapy. 16(9):1587-93 [DOI] 10.1038/mt.2008.140. [PMID] 18594506.
2007
Aging effects on the limits and stability of long-term synaptic potentiation and depression in rat hippocampal area CA1.
Journal of neurophysiology. 98(2):594-601 [PMID] 17553951.
2007
Effect of bevacizumab on radiation necrosis of the brain.
International journal of radiation oncology, biology, physics. 67(2):323-6 [PMID] 17236958.
2007
Susceptibility to induction of long-term depression is associated with impaired memory in aged Fischer 344 rats.
Neurobiology of learning and memory. 87(4):522-35 [PMID] 17276704.
2006
Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis.
Molecular therapy : the journal of the American Society of Gene Therapy. 13(3):565-72 [PMID] 16223604.

Grants

Aug 2020 ACTIVE
Age-associated impaired executive function: Rescue by NMDA receptor upregulation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Jul 2018 ACTIVE
Estrogen and cognition over the lifespan
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA

Contact Details

Phones:
Business:
(352) 392-4085
Emails:
Business:
kash@ufl.edu
Addresses:
Business Mailing:
BLDG 59, L2-128
PO BOX 100244
100 S NEWELL DRIVE
GAINESVILLE FL 326100244