Ashok Kumar

Ashok Kumar

Research Associate Professor

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 392-4085
Business Email: kash@ufl.edu

Publications

2020
Calcium Signaling During Brain Aging and Its Influence on the Hippocampal Synaptic Plasticity.
Advances in experimental medicine and biology. 1131:985-1012 [DOI] 10.1007/978-3-030-12457-1_39. [PMID] 31646542.
2019
Behavior Model for Assessing Decline in Executive Function During Aging and Neurodegenerative Diseases.
Methods in molecular biology (Clifton, N.J.). 2011:441-449 [DOI] 10.1007/978-1-4939-9554-7_26. [PMID] 31273715.
2018
Nonsteroidal anti-inflammatory drug, indomethacin improves spatial memory and NMDA receptor function in aged animals.
Neurobiology of aging. 70:184-193 [DOI] 10.1016/j.neurobiolaging.2018.06.026. [PMID] 30031231.
2018
NS6740, an α7 nicotinic acetylcholine receptor silent agonist, disrupts hippocampal synaptic plasticity.
Neuroscience letters. 677:6-13 [DOI] 10.1016/j.neulet.2018.04.025. [PMID] 29679680.
2018
Search for Heavy Neutral Leptons in Events With Three Charged Leptons in Proton-Proton Collisions at Root S=13 Tev
Physical Review Letters. 120(22) [DOI] 10.1103/PhysRevLett.120.221801.
2018
Search for the Pair Production of Third-Generation Squarks With Two-Body Decays to a Bottom or Charm Quark and a Neutralino in Proton-Proton Collisions at Root S=13 Tev
Physics Letters B. 778:263-291 [DOI] 10.1016/j.physletb.2018.01.012.
2018
The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury.
Frontiers in physiology. 9 [DOI] 10.3389/fphys.2018.00180. [PMID] 29636695.
2015
Impaired attention and synaptic senescence of the prefrontal cortex involves redox regulation of NMDA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(9):3966-77 [DOI] 10.1523/JNEUROSCI.3523-14.2015. [PMID] 25740525.
2015
Re-Opening the Critical Window for Estrogen Therapy.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(49):16077-93 [DOI] 10.1523/JNEUROSCI.1890-15.2015. [PMID] 26658861.
2014
Assessing the emergence and reliability of cognitive decline over the life span in Fisher 344 rats using the spatial water maze.
Frontiers in aging neuroscience. 6 [DOI] 10.3389/fnagi.2014.00002. [PMID] 24478698.
2014
Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses.
Hippocampus. 24(4):466-75 [DOI] 10.1002/hipo.22240. [PMID] 24390964.
2014
Role of antioxidant enzymes in redox regulation of N-methyl-D-aspartate receptor function and memory in middle-aged rats.
Neurobiology of aging. 35(6):1459-68 [DOI] 10.1016/j.neurobiolaging.2013.12.002. [PMID] 24388786.
2013
Daily exercise improves memory, stimulates hippocampal neurogenesis and modulates immune and neuroimmune cytokines in aging rats.
Brain, behavior, and immunity. 28:25-43 [DOI] 10.1016/j.bbi.2012.09.013. [PMID] 23078985.
2013
Environmental enrichment restores neurogenesis and rapid acquisition in aged rats.
Neurobiology of aging. 34(1):263-74 [DOI] 10.1016/j.neurobiolaging.2012.05.023. [PMID] 22795793.
2013
Linking redox regulation of NMDAR synaptic function to cognitive decline during aging.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(40):15710-5 [DOI] 10.1523/JNEUROSCI.2176-13.2013. [PMID] 24089479.
2013
Memory in Aged Mice Is Rescued By Enhanced Expression of the Glun2B Subunit of the Nmda Receptor
Behavioural brain research. 238:211-226 [DOI] 10.1016/j.bbr.2012.10.026. [PMID] 23103326.
2013
Role of estrogen receptor α and β in preserving hippocampal function during aging.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(6):2671-83 [DOI] 10.1523/JNEUROSCI.4937-12.2013. [PMID] 23392694.
2012
Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology.
Neurobiology of aging. 33(4):828.e1-17 [DOI] 10.1016/j.neurobiolaging.2011.06.023. [PMID] 21820213.
2012
Influence of viral vector-mediated delivery of superoxide dismutase and catalase to the hippocampus on spatial learning and memory during aging.
Antioxidants & redox signaling. 16(4):339-50 [DOI] 10.1089/ars.2011.4054. [PMID] 21942371.
2012
Similarities and Dissimilarities of Two Experimental Models of Tbi (Closed Head and Blast Tbi) in Long-Term Disabilities: Spasticity, Cognitive and Synaptic Function, Balance, Anxiety, and Pain Related Behaviors
Journal of Neurotrauma. 29:A56-A57
2012
Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology.
Neurobiology of learning and memory. 97(1):69-80 [DOI] 10.1016/j.nlm.2011.09.006. [PMID] 21982980.
2010
Carbachol-induced long-term synaptic depression is enhanced during senescence at hippocampal CA3-CA1 synapses.
Journal of neurophysiology. 104(2):607-16 [DOI] 10.1152/jn.00278.2010. [PMID] 20505129.
2010
Flagellin-Induced Corneal Antimicrobial Peptide Production and Wound Repair Involve a Novel Nf-Kappa B-Independent and Egfr-Dependent Pathway
PLoS One. 5(2) [DOI] 10.1371/journal.pone.0009351. [PMID] 20195469.
2010
Intracellular redox state alters NMDA receptor response during aging through Ca2+/calmodulin-dependent protein kinase II.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(5):1914-24 [DOI] 10.1523/JNEUROSCI.5485-09.2010. [PMID] 20130200.
2010
PHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus.
Journal of neurochemistry. 115(4):941-55 [DOI] 10.1111/j.1471-4159.2010.06984.x. [PMID] 20819118.
2009
Estrogen effects on cognition and hippocampal transcription in middle-aged mice.
Neurobiology of aging. 30(6):932-45 [PMID] 17950954.
View on: PubMed
2009
Fragile X mental retardation protein replacement restores hippocampal synaptic function in a mouse model of fragile X syndrome.
Gene therapy. 16(9):1122-9 [DOI] 10.1038/gt.2009.83. [PMID] 19571888.
2009
Regional hippocampal differences in AKT survival signaling across the lifespan: implications for CA1 vulnerability with aging.
Cell death and differentiation. 16(3):439-48 [DOI] 10.1038/cdd.2008.171. [PMID] 19039330.
2008
AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation.
Investigative ophthalmology & visual science. 49(10):4278-83 [DOI] 10.1167/iovs.07-1622. [PMID] 18586879.
2008
Viral vector-mediated delivery of estrogen receptor-alpha to the hippocampus improves spatial learning in estrogen receptor-alpha knockout mice.
Molecular therapy : the journal of the American Society of Gene Therapy. 16(9):1587-93 [DOI] 10.1038/mt.2008.140. [PMID] 18594506.
2007
Aging effects on the limits and stability of long-term synaptic potentiation and depression in rat hippocampal area CA1.
Journal of neurophysiology. 98(2):594-601 [PMID] 17553951.
View on: PubMed
2007
Susceptibility to induction of long-term depression is associated with impaired memory in aged Fischer 344 rats.
Neurobiology of learning and memory. 87(4):522-35 [PMID] 17276704.
View on: PubMed
2006
Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis.
Molecular therapy : the journal of the American Society of Gene Therapy. 13(3):565-72 [PMID] 16223604.
View on: PubMed

Grants

Aug 2020 ACTIVE
Age-associated impaired executive function: Rescue by NMDA receptor upregulation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Jul 2018 ACTIVE
Estrogen and cognition over the lifespan
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA

Teaching Profile

Courses Taught
2016-2020
GMS6592 Ion Channels Journal Club: Pharmacology, Biophysics, and Neuroscience of Excitable Membranes
2008
EML5526 Finite Elem Analysis

Contact Details

Phones:
Business:
(352) 392-4085
Emails:
Business:
kash@ufl.edu