Marieta B Heaton

Marieta B Heaton,

Professor

Department: Department of Neuroscience
Business Phone: (352) 273-5094
Business Email: heaton@ufl.edu

Teaching Profile

Courses Taught
2018-2020,2022-2023
GMS6705 Functional Human Neuroanatomy
2020
GMS7795 Special Topics in Neuroscience
2007-2008,2014-2022,2021-2023
GMS6021 Organization and Development of the Nervous System
2021-2023
GMS6073 Disorders of the Developing Nervous System

Publications

2015
Differential effects of ethanol on bid, tBid, and Bax:tBid interactions in postnatal day 4 and postnatal day 7 rat cerebellum.
Alcoholism, clinical and experimental research. [DOI] 10.1111/acer.12603. [PMID] 25623406.
2013
Ethanol influences on Bax associations with mitochondrial membrane proteins in neonatal rat cerebellum.
Developmental neurobiology. [DOI] 10.1002/dneu.22042. [PMID] 22767450.
2012
Differential effects of ethanol on c-jun N-terminal kinase, 14-3-3 proteins, and Bax in postnatal day 4 and postnatal day 7 rat cerebellum.
Brain research. [DOI] 10.1016/j.brainres.2011.11.010. [PMID] 22169498.
2011
Ethanol influences on Bax translocation, mitochondrial membrane potential, and reactive oxygen species generation are modulated by vitamin E and brain-derived neurotrophic factor.
Alcoholism, clinical and experimental research. [DOI] 10.1111/j.1530-0277.2011.01445.x. [PMID] 21332533.
2006
Effect of bax deletion on ethanol sensitivity in the neonatal rat cerebellum.
Journal of neurobiology. [PMID] 16215995.
2006
Effects of acute ethanol exposure on regulatory mechanisms of Bcl-2-associated apoptosis promoter, bad, in neonatal rat cerebellum: differential effects during vulnerable and resistant developmental periods.
Alcoholism, clinical and experimental research. [PMID] 16737462.
2005
Functional mechanisms of apoptosis-related proteins in neonatal rat cerebellum are differentially influenced by ethanol at postnatal days 4 and 7.
Journal of neuroscience research. [PMID] 16035105.
2005
Mitochondrially targeted vitamin E and vitamin E mitigate ethanol-mediated effects on cerebellar granule cell antioxidant defense systems.
Brain research. [PMID] 16024002.
2004
Ethanol-induced reduction of neurotrophin secretion in neonatal rat cerebellar granule cells is mitigated by vitamin E.
Neuroscience letters. [PMID] 15489016.
2004
Protective mechanisms of pycnogenol in ethanol-insulted cerebellar granule cells.
Journal of neurobiology. [PMID] 15389691.
2004
Pycnogenol and vitamin E inhibit ethanol-induced apoptosis in rat cerebellar granule cells.
Journal of neurobiology. [PMID] 15146544.
2004
Vitamin E amelioration of ethanol neurotoxicity involves modulation of apoptotis-related protein levels in neonatal rat cerebellar granule cells.
Brain research. Developmental brain research. [PMID] 15158075.
2003
Effects of ethanol on neurotrophic factors, apoptosis-related proteins, endogenous antioxidants, and reactive oxygen species in neonatal striatum: relationship to periods of vulnerability.
Brain research. Developmental brain research. [PMID] 12586429.
2003
Ethanol effects on neonatal rat cortex: comparative analyses of neurotrophic factors, apoptosis-related proteins, and oxidative processes during vulnerable and resistant periods.
Brain research. Developmental brain research. [PMID] 14604765.
2003
Nerve growth factor and chronic ethanol treatment alter calcium homeostasis in developing rat septal neurons.
Brain research. Developmental brain research. [PMID] 12763581.
2003
The role of neurotrophic factors, apoptosis-related proteins, and endogenous antioxidants in the differential temporal vulnerability of neonatal cerebellum to ethanol.
Alcoholism, clinical and experimental research. [PMID] 12711928.
2002
Ethanol-mediated generation of reactive oxygen species in developing rat cerebellum.
Neuroscience letters. [PMID] 12435477.
2002
Influence of ethanol on neonatal cerebellum of BDNF gene-deleted animals: analyses of effects on Purkinje cells, apoptosis-related proteins, and endogenous antioxidants.
Journal of neurobiology. [PMID] 11932957.
2002
The effects of chronic ethanol consumption on neurotrophins and their receptors in the rat hippocampus and basal forebrain.
Brain research. [PMID] 12231238.
2000
Amelioration of ethanol-induced neurotoxicity in the neonatal rat central nervous system by antioxidant therapy.
Alcoholism, clinical and experimental research. [PMID] 10798588.
2000
Effect of neonatal ethanol exposure on parvalbumin-expressing GABAergic neurons of the rat medial septum and cingulate cortex.
Alcohol (Fayetteville, N.Y.). [PMID] 10946157.
2000
Ethanol-induced alterations in the expression of neurotrophic factors in the developing rat central nervous system.
Brain research. Developmental brain research. [PMID] 10837897.
2000
Neurotrophic factor protection against ethanol toxicity in rat cerebellar granule cell cultures requires phosphatidylinositol 3-kinase activation.
Neuroscience letters. [PMID] 10978589.
2000
Overexpression of NGF ameliorates ethanol neurotoxicity in the developing cerebellum.
Journal of neurobiology. [PMID] 11018771.
1999
Bcl-2 overexpression protects the neonatal cerebellum from ethanol neurotoxicity.
Brain research. [PMID] 9889302.
1999
BDNF and NGF afford in vitro neuroprotection against ethanol combined with acute ischemia and chronic hypoglycemia.
Developmental neuroscience. [PMID] 10077704.
1999
Ethanol-induced alterations in neurotrophin expression in developing cerebellum: relationship to periods of temporal susceptibility.
Alcoholism, clinical and experimental research. [PMID] 10549996.
1999
Neonatal ethanol exposure alters bcl-2 family mRNA levels in the rat cerebellar vermis.
Alcoholism, clinical and experimental research. [PMID] 10443994.
1999
Neurotrophic factors BDNF and GDNF protect embryonic chick spinal cord motoneurons from ethanol neurotoxicity in vivo.
Brain research. Developmental brain research. [PMID] 9974163.
1999
Prenatal ethanol exposure reduces spinal cord motoneuron number in the fetal rat but does not affect GDNF target tissue protein.
Developmental Neuroscience. [PMID] 10640863.
1999
The antioxidants vitamin E and beta-carotene protect against ethanol-induced neurotoxicity in embryonic rat hippocampal cultures.
Alcohol (Fayetteville, N.Y.). [PMID] 10064385.
1999
Vitamin E and beta-carotene protect against ethanol combined with ischemia in an embryonic rat hippocampal culture model of fetal alcohol syndrome.
Neuroscience letters. [PMID] 10213167.
1998
A comparative study of ethanol, hypoglycemia, hypoxia and neurotrophic factor interactions with fetal rat hippocampal neurons: a multi-factor in vitro model developmental ethanol effects.
Brain research. Developmental brain research. [PMID] 9541742.
1998
Effects of neonatal ethanol exposure on cholinergic neurons of the rat medial septum.
Alcohol (Fayetteville, N.Y.). [PMID] 9539379.
1998
Optimal 96-well plate set-up to avoid ethanol volatility when assessing ethanol cytotoxicity.
Alcohol (Fayetteville, N.Y.). [PMID] 9476959.
1998
Prenatal ethanol exposure reduces parvalbumin-immunoreactive GABAergic neuronal number in the adult rat cingulate cortex.
Neuroscience letters. [PMID] 9672380.
1997
Cultured postnatal rat septohippocampal neurons change intracellular calcium in response to ethanol and nerve growth factor.
Brain research. [PMID] 9459553.
1997
Effects of prenatal ethanol exposure on parvalbumin-expressing GABAergic neurons in the adult rat medial septum.
Alcoholism, clinical and experimental research. [PMID] 9267534.
1997
Ethanol effects on cultured embryonic hippocampal neuronal calcium homeostasis are altered by nerve growth factor.
Alcoholism, clinical and experimental research. [PMID] 9438525.
1997
Ethanol influences on the chick embryo spinal cord motor system. II. Effects of neuromuscular blockade and period of exposure.
Journal of neurobiology. [PMID] 9183746.
1997
Immunohistochemical localization of netrin-1 in the embryonic chick nervous system.
The Journal of neuroscience : the official journal of the Society for Neuroscience. [PMID] 9204929.
1996
Calcium homeostasis in cultured embryonic rat septohippocampal neurons is altered by ethanol and nerve growth factor before and during depolarization.
Brain research. [PMID] 8876986.
1996
Cultured postnatal rat medial septal neurons respond to acute ethanol treatment and nerve growth factor by changing intracellular calcium levels.
Alcoholism, clinical and experimental research. [PMID] 8947314.
1996
Influence of chronic prenatal ethanol on cholinergic neurons of the septohippocampal system.
The Journal of comparative neurology. [PMID] 8789279.
1996
Influence of prenatal ethanol exposure on cholinergic development in the rat striatum.
The Journal of comparative neurology. [PMID] 8789280.
1996
Up-regulation of high-affinity neurotrophin receptor, trk B-like protein on western blots of rat cortex after chronic ethanol treatment.
Brain research. Molecular brain research. [PMID] 8840027.
1995
A method for labeling embryonic rat medial septal region projection neurons, in vitro, using fluorescent tracers.
Brain research bulletin. [PMID] 7627577.
1995
Alterations in responsiveness to ethanol and neurotrophic substances in fetal septohippocampal neurons following chronic prenatal ethanol exposure.
Brain research. Developmental brain research. [PMID] 7781156.
1995
Chronic prenatal ethanol exposure alters the normal ontogeny of choline acetyltransferase activity in the rat septohippocampal system.
Alcoholism, clinical and experimental research. [PMID] 8561298.
1995
Ethanol and nerve growth factor effects on calcium homeostasis in cultured embryonic rat medial septal neurons before and during depolarization.
Brain research. [PMID] 8925300.
1995
Ethanol influences on the chick embryo spinal cord motor system: analyses of motoneuron cell death, motility, and target trophic factor activity and in vitro analyses of neurotoxicity and trophic factor neuroprotection.
Journal of neurobiology. [PMID] 7714525.
1995
In vitro comparison of the effects of ethanol and acetaldehyde on dorsal root ganglion neurons.
Alcoholism, clinical and experimental research. [PMID] 8561313.
1995
Perturbation of target-directed neurite outgrowth in embryonic CNS co-cultures grown in the presence of ethanol.
Brain research. Developmental brain research. [PMID] 8612330.
1995
Prenatal ethanol exposure alters neurotrophic activity in the developing rat hippocampus.
Neuroscience letters. [PMID] 7792057.
1994
Chronic alcohol ingestion: nerve growth factor gene expression and neurotrophic activity in rat hippocampus.
Alcoholism, clinical and experimental research. [PMID] 7695032.
1994
Chronic ethanol alters CNS cholinergic and cerebellar development in chick embryos.
Alcohol (Fayetteville, N.Y.). [PMID] 8060518.
1994
Ethanol neurotoxicity in vitro: effects of GM1 ganglioside and protein synthesis inhibition.
Brain research. [PMID] 7987683.
1994
Responsiveness of cultured septal and hippocampal neurons to ethanol and neurotrophic substances.
Journal of neuroscience research. [PMID] 7869423.
1993
Disruption of species-specific behavior in neonatal quail following chronic prenatal ethanol exposure.
Behavioral and neural biology. [PMID] 8503829.
1993
Effect of chronic ethanol on the septohippocampal system: a role for neurotrophic factors?
Alcoholism, clinical and experimental research. [PMID] 8452192.
1993
Modulation of ethanol neurotoxicity by nerve growth factor.
Brain research. [PMID] 8402202.
1993
Neurotrophic activity in embryonic chick brain: early appearance and differential regional distribution.
Developmental neuroscience. [PMID] 8269862.
1992
Chronic ethanol consumption reduces the neurotrophic activity in rat hippocampus.
Neuroscience letters. [PMID] 1480327.
1992
Ethanol exposure affects trophic factor activity and responsiveness in chick embryo.
Alcohol (Fayetteville, N.Y.). [PMID] 1599628.
1990
Comparative responsiveness of early chick neural tube neurons to muscle-conditioned medium, laminin, NGF and fibronectin.
Brain research. Developmental brain research. [PMID] 2331779.
1990
The ontogeny of specific retrograde transport of nerve growth factor by motoneurons of the brainstem and spinal cord.
Developmental biology. [PMID] 1690677.
1990
The response of cultured trigeminal and spinal cord motoneurons to nerve growth factor.
Developmental biology. [PMID] 2156739.
1989
Axonal transport and central visual projections of ganglion cells in congenitally blind chickens.
Current eye research. [PMID] 2539951.
1989
Comparative responsiveness of early chick embryo brainstem and spinal cord neurons to target-conditioned medium.
Developmental neuroscience. [PMID] 2806135.
1989
Influence of laminin on the responsiveness of early chick embryo neural tube neurons to nerve growth factor.
Journal of neuroscience research. [PMID] 2760940.
1988
Retrograde transport of NGF by early chick embryo spinal cord motoneurons.
Developmental biology. [PMID] 2452104.
1988
Some characteristics of muscle-conditioned media with excitatory and inhibitory influences on neurite outgrowth from early neural tube explants.
Journal of neuroscience research. [PMID] 3343710.
1988
Species specificity in the responsiveness of chick embryo neural tube explants to target-conditioned medium.
Brain research. [PMID] 3342327.
1988
The influence of laminin on the initial differentiation of cultured neural tube neurons.
Journal of neuroscience research. [PMID] 3367395.
1987
Influence of nerve growth factor on chick trigeminal motor nucleus explants.
The Journal of comparative neurology. [PMID] 3693610.
1987
The influence of muscle-conditioned media on chick embryo brainstem neurons in culture.
Journal of neuroscience research. [PMID] 3625803.
1986
Specific responsiveness of chick trigeminal motor nucleus explants to target-conditioned media.
The Journal of comparative neurology. [PMID] 3950080.
1986
The influence of target tissue age on neurite outgrowth from chick embryo trigeminal motor nucleus explants.
Developmental biology. [PMID] 3732609.
1983
Developmental relationships between trigeminal ganglia and trigeminal motoneurons in chick embryos. I. Ganglion development is necessary for motoneuron migration.
The Journal of comparative neurology. [PMID] 6601116.
1983
Developmental relationships between trigeminal ganglia and trigeminal motoneurons in chick embryos. II. Ganglion axon ingrowth guides motoneuron migration.
The Journal of comparative neurology. [PMID] 6601117.
1983
Developmental relationships between trigeminal ganglia and trigeminal motoneurons in chick embryos. III. Ganglion perikarya direct motor axon growth in the periphery.
The Journal of comparative neurology. [PMID] 6601118.
1983
Patterns of extraocular innervation by the oculomotor complex in the chick.
The Journal of comparative neurology. [PMID] 6306064.
1983
Ultrastructural observations of the migration and early development of trigeminal motoneurons in chick embryos.
The Journal of comparative neurology. [PMID] 6863595.
1982
A technique for improved resolution of [3H]thymidine autoradiography in the avian embryo: a preliminary report.
Journal of neuroscience methods. [PMID] 7057686.
1981
Morphology of migrating trigeminal motor neuroblasts as revealed by horseradish peroxidase retrograde labeling techniques.
Neuroscience. [PMID] 7301120.
1981
Prenatal auditory discrimination in the bobwhite quail.
Behavioral and neural biology. [PMID] 7259706.
1981
The development of the oculomotor nuclear complex in the Japanese quail embryo.
The Journal of comparative neurology. [PMID] 7251933.
1980
Early development and migration of the trigeminal motor nucleus in the chick embryo.
The Journal of comparative neurology. [PMID] 6965380.
1980
Learning deficits in the neonatal Peking duckling produced by decreased oxygen consumption during late prenatal periods: a cautionary note.
Developmental psychobiology. [PMID] 7429023.
1979
Oculomotor neuroblast migration in the chick embryo in the absence of tecto-tegmental fibers.
Developmental biology. [PMID] 437323.
1979
The displaced ganglion cell in the avian retina: developmental and comparative considerations.
Anatomy and embryology. [PMID] 84539.
1978
Head holder for avian embryos.
Physiology & behavior. [PMID] 358220.
1978
Micro-injections in the avian embryo: technical notes.
Brain research bulletin. [PMID] 318195.
1978
Peripheral innervation by migrating neuroblasts in the chick embryo.
Neuroscience letters. [PMID] 19605256.
1978
Species-specific auditory discrimination in bobtail quail neonates.
Developmental psychobiology. [PMID] 631431.
1978
Visual system development in the duck embryo.
Experimental neurology. [PMID] 627268.
1977
Retrograde axonal transport in lateral motor neurons of the chick embryo prior to limb bud innervation.
Developmental biology. [PMID] 885294.
1977
Tectal projection of displaced ganglion cells in avian retina.
Investigative ophthalmology & visual science. [PMID] 885687.
1975
Behavioral adaptation in neonatal chicks following embryonic vestibular system rearrangement.
The Journal of experimental zoology. [PMID] 1081584.
1975
The retrograde transport of horseradish peroxidase from the developing limb of the chick embryo.
Brain research. [PMID] 1182520.
1974
Developing visual function in the pigeon embryo with comparative reference to other avian species.
Journal of comparative and physiological psychology. [PMID] 4809970.
1974
Non-visual light responsiveness in the pigeon: developmental and comparative considerations.
The Journal of experimental zoology. [PMID] 4836187.
1973
Xenoplastic eye transplantation between chick and quail embryos: some neuroanatomical and functional aspects.
The Journal of comparative neurology. [PMID] 4754839.
1971
Ontogeny of vision in the Peking duck (Anas platyrhynchos): the pupillary light reflex as a means for investigating visual onset and development in avian embryos.
Developmental psychobiology. [PMID] 5162587.

Grants

Sep 2017 – Aug 2021
Critical Mechanisms Underlying THC Neurotoxicity in Developing CNS
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
Aug 2016 – Jul 2018
Mechanisms of Choline Mitigation of Ethanol Toxicity in Developing CNS
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAAA

Contact Details

Phones:
Business:
(352) 273-5094
Emails:
Business:
heaton@ufl.edu
Addresses:
Business Mailing:
PO Box 100244
GAINESVILLE FL 32610
Business Street:
MCKNIGHT BRAIN INSTITUTE
MCKNIGHT BRAIN INSTITUTE
DEPARTMENT OF NEUROSCIENCE
GAINESVILLE FL 326100001