Drs. Malu Tansey and Rebecca Wallings publish a new review in Biochemical Society Transactions that reviews the role of LRRK2 mutation in pathway regulation in immune cells. Drawing upon data from multiple diseases associated with LRRK2, they highlight the pleiotropic effects of LRRK2 in different cell types. They further role of the bona fide LRRK2 substrate, Rab GTPases, in LRRK2 pathway regulation as well as downstream events in the autophagy and inflammatory pathways.
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