Wolfgang J. Streit, Ph.D.

Wolfgang StreitProfessor

Department of Neuroscience
University of Florida
1149 Newell Drive
Gainesville, FL  32611-0244
Email:            pschorr@ufl.edu
Office Phone:  (352) 273-5096
Lab Phone:      (352) 392-9596

Education:

1985 Ph.D.
(Pathology/Neuropathology)
Medical University of South Carolina
Charleston, SC
1985-1986 Postdoctoral Fellowship
(Neurobiology)
Max Planc Institute for Neurobiology
Martinsried, Germany
1986-1989 Staff Scientist
(Neurobiology)
Max Planc Institute for Neurobiology
Martinsried, Germany

Key Words:   Microglial Cells; Experimental Neuropathology; Neuroimmunology; Neuroinflammation; Alzheimer’s disease

Research Summary:

My research is focused on the role of microglial cells during brain aging and in the development of sporadic (late-onset) Alzheimer’s disease (LOAD) in human subjects. Specifically, we are examining temporal and spatial relationships between different microglial phenotypes, amyloid deposits, and neurofibrillary degeneration at preclinical stages of LOAD. Our findings to date show that neurofibrillary degeneration occurs in the absence of microglial activation and in the absence of amyloid deposits, suggesting that its development occurs independently of amyloid deposits or neuroinflammation. Additionally, in collaborative work we are studying the role of microglia in drug addiction during HIV infection.
View All Publications through pubmeb