
Research in neural development examines the processes that shape the nervous system from embryo to adulthood. Faculty investigate how neural cells differentiate, migrate and form connections, as well as how environmental factors influence developmental pathways.
Using both model organisms and human systems, researchers seek to uncover the genetic and molecular mechanisms underlying brain development and the emergence of complex behaviors. This work provides critical insight into developmental and neurological disorders and advances our understanding of brain plasticity across the lifespan.
The mature nervous system comes into being during embryonic and post-embryonic development as a result of a series of developmental programs that include the birth of nerve cells and their supporting (glia) cells, the migration of these cells to defined locations within the developing nervous tissue, the establishment of connections of these cells to specific target areas, and selective neuronal cell death. Once established, we now know that the mature nervous system exhibits an amazing degree of plasticity, changing in response to experience and use. Information gained in studies of the factors that influence nervous system development and plasticity may provide a key toward unlocking the potential of the mature nervous system.
Faculty Mentors
| Name | Department | Research Area | Disease Focus |
|---|---|---|---|
| David C. Bloom | Molecular Genetics & Microbiology | Development; Neural Aging and Degeneration; Neuroimmunity | N/A |
| Eduardo Candelario-Jalil | Neuroscience | Development; Neuroimmunity | Spinal Cord Injury; Stroke |
| Paramita Chakrabarty | Neuroscience | Cognition; Development; Neural Aging and Degeneration; Neuroimmunity | Alzheimer’s Disease & Dementia |
| Vijayendran Chandran | Pediatrics | Development; Motor Systems; Neural Aging and Degeneration | Spinal Cord Injury; Neuromuscular Disorders |
| Loic Deleyrolle | Neurosurgery | Neuroimmunity; Development | Brain cancer |
| Darragh P. Devine | Psychology | Cognition; Development; Integrative Physiology and Behavior; Motivation and Emotion | Psychiatric Disorders |
| Daniel J. Driscoll | Peds Genetics | Development | N/A |
| Yuqing Li | Neurology | Cognition; Development; Motor Systems; Neural Aging and Degeneration | Alzheimer’s Disease & Dementia; Psychiatric Disorders |
| Ron J. Mandel | Neuroscience | Development; Motivation and Emotion; Neural Aging and Degeneration | Parkinson’s Disease; Psychiatric Disorders |
| Christopher J. Martyniuk | Physiological Sciences | Development; Motivation and Emotion | Psychiatric Disorders |
| Anatoly E. Martynyuk | Anesthesiology | Development; Motivation and Emotion | Psychiatric Disorders |
| Carol Mathews | Psychiatry | Cognition; Development; Motivation and Emotion; Motor Systems; Neural Aging and Degeneration; Sensory Systems | Psychiatric Disorders |
| Gordon S. Mitchell | Physical Therapy | Development; Integrative Physiology and Behavior; Motor Systems; Neural Aging and Degeneration; Neural Excitability, Synapses and Glia; Neuroimmunity | Spinal Cord Injury; Neuromuscular Disorders |
| Leonid L. Moroz | Neuroscience | Cognition; Development; Integrative Physiology and Behavior; Neural Excitability, Synapses and Glia | N/A |
| Stefan Prokop | Pathology | Development; Neural Aging and Degeneration; Neuroimmunity | Alzheimer’s Disease & Dementia; Brain Cancer; Neuromuscular Disorders; Parkinson’s Disease |
| Maryam Rahman | Neurosurgery | Neuroimmunity; Development | Brain Cancer |
| Laura P. Ranum | Molecular Genetics & Microbiology | Development; Motor Systems | Neuromuscular Disorders; Alzheimer’s Disease & Dementia |
| Brent A. Reynolds | Neurosurgery | Development; Neural Aging and Degeneration | Brain Cancer |
| Diego E. Rincon-Limas | Neurology | Development; Neural Aging and Degeneration | Alzheimer’s Disease & Dementia |
| Matt R. Sarkisian | Neuroscience | Development | Brain Cancer |
| Elias J. Sayour | Neurosurgery | Neuroimmunity; Development | Brain Cancer |
| Maurice S. Swanson | Molecular Genetics & Microbiology | Development; Neural Aging and Degeneration | Neuromuscular Disorders |
| Roberto T. Zori | Pediatric Genetics | Cognition; Development; Integrative Physiology and Behavior | N/A |
Key Affiliations
Center for Addiction Research & Education
Center for Autism and Neurodevelopment
Center for NeuroGenetics