Development

Neuron with Cilia

Research in neural development examines the processes that shape the nervous system from embryo to adulthood. Faculty investigate how neural cells differentiate, migrate and form connections, as well as how environmental factors influence developmental pathways.

Using both model organisms and human systems, researchers seek to uncover the genetic and molecular mechanisms underlying brain development and the emergence of complex behaviors. This work provides critical insight into developmental and neurological disorders and advances our understanding of brain plasticity across the lifespan.

The mature nervous system comes into being during embryonic and post-embryonic development as a result of a series of developmental programs that include the birth of nerve cells and their supporting (glia) cells, the migration of these cells to defined locations within the developing nervous tissue, the establishment of connections of these cells to specific target areas, and selective neuronal cell death. Once established, we now know that the mature nervous system exhibits an amazing degree of plasticity, changing in response to experience and use. Information gained in studies of the factors that influence nervous system development and plasticity may provide a key toward unlocking the potential of the mature nervous system.

Faculty Mentors

NameDepartmentResearch AreaDisease Focus
David C. BloomMolecular Genetics & MicrobiologyDevelopment; Neural Aging and Degeneration; NeuroimmunityN/A
Eduardo Candelario-JalilNeuroscienceDevelopment; NeuroimmunitySpinal Cord Injury; Stroke
Paramita ChakrabartyNeuroscienceCognition; Development; Neural Aging and Degeneration; NeuroimmunityAlzheimer’s Disease & Dementia
Vijayendran ChandranPediatricsDevelopment; Motor Systems; Neural Aging and DegenerationSpinal Cord Injury; Neuromuscular Disorders
Loic DeleyrolleNeurosurgeryNeuroimmunity; DevelopmentBrain cancer
Darragh P. DevinePsychologyCognition; Development; Integrative Physiology and Behavior; Motivation and EmotionPsychiatric Disorders
Daniel J. DriscollPeds GeneticsDevelopmentN/A
Yuqing LiNeurologyCognition; Development; Motor Systems; Neural Aging and DegenerationAlzheimer’s Disease & Dementia; Psychiatric Disorders
Ron J. MandelNeuroscienceDevelopment; Motivation and Emotion; Neural Aging and DegenerationParkinson’s Disease; Psychiatric Disorders
Christopher J. MartyniukPhysiological SciencesDevelopment; Motivation and EmotionPsychiatric Disorders
Anatoly E. MartynyukAnesthesiologyDevelopment; Motivation and EmotionPsychiatric Disorders
Carol MathewsPsychiatryCognition; Development; Motivation and Emotion; Motor Systems; Neural Aging and Degeneration; Sensory SystemsPsychiatric Disorders
Gordon S. MitchellPhysical TherapyDevelopment; Integrative Physiology and Behavior; Motor Systems; Neural Aging and Degeneration; Neural Excitability, Synapses and Glia; NeuroimmunitySpinal Cord Injury; Neuromuscular Disorders
Leonid L. MorozNeuroscienceCognition; Development; Integrative Physiology and Behavior; Neural Excitability, Synapses and GliaN/A
Stefan ProkopPathologyDevelopment; Neural Aging and Degeneration; NeuroimmunityAlzheimer’s Disease & Dementia; Brain Cancer; Neuromuscular Disorders; Parkinson’s Disease
Maryam RahmanNeurosurgeryNeuroimmunity; DevelopmentBrain Cancer
Laura P. RanumMolecular Genetics & MicrobiologyDevelopment; Motor SystemsNeuromuscular Disorders; Alzheimer’s Disease & Dementia
Brent A. ReynoldsNeurosurgeryDevelopment; Neural Aging and DegenerationBrain Cancer
Diego E. Rincon-LimasNeurologyDevelopment; Neural Aging and DegenerationAlzheimer’s Disease & Dementia
Matt R. SarkisianNeuroscienceDevelopmentBrain Cancer
Elias J. SayourNeurosurgeryNeuroimmunity; DevelopmentBrain Cancer
Maurice S. SwansonMolecular Genetics & MicrobiologyDevelopment; Neural Aging and DegenerationNeuromuscular Disorders
Roberto T. ZoriPediatric GeneticsCognition; Development; Integrative Physiology and BehaviorN/A

Key Affiliations