Changjun Yang,
Research Assistant Professor
Department:
Department of Neuroscience
Business Phone:
(352) 273-6764
Business Email:
changjunyang@ufl.edu
Research Profile
My work is trying to investigate molecular mechanisms involved in focal ischemic injury and develop novel therapeutic strategies for treatment of ischemic stroke. Specifically, I aim to elucidate the roles of oxidative stress and neuroinflammation in maintaining or disrupting blood brain barrier (BBB) integrity in ischemic stroke using in vitro cell cultures and in vivo models of transient or permanent middle cerebral artery occlusion (MCAO) in rats and mice.
Areas of Interest
- cerebral ischemia
- myocardial ischemia
Open Researcher and Contributor ID (ORCID)
0000-0001-6253-7207
Publications
2023
Neuroprotection by the cannabidiol aminoquinone VCE-004.8 in experimental ischemic stroke in mice.
Neurochemistry international.
165
[DOI] 10.1016/j.neuint.2023.105508.
[PMID] 36863495.
2023
Protective Roles of Adropin in Neurological Disease.
American journal of physiology. Cell physiology.
324(3):C674-C678
[DOI] 10.1152/ajpcell.00318.2022.
[PMID] 36717106.
2023
Receptor-interacting protein kinase 2 (RIPK2) profoundly contributes to post-stroke neuroinflammation and behavioral deficits with microglia as unique perpetrators.
Journal of neuroinflammation.
20(1)
[DOI] 10.1186/s12974-023-02907-6.
[PMID] 37777791.
2022
An Unexplored Role for MMP-7 (Matrix Metalloproteinase-7) in Promoting Gut Permeability After Ischemic Stroke
Stroke.
53(10):3238-3242
[DOI] 10.1161/strokeaha.122.040144.
2022
Editorial: Inflammation in ischemic stroke and novel therapeutic strategies for stroke treatment.
Frontiers in neurology.
13
[DOI] 10.3389/fneur.2022.1071557.
[PMID] 36468068.
2022
Ischemic Stroke Impacts the Gut Microbiome, Ileal Epithelial and Immune Homeostasis.
iScience.
25(11)
[DOI] 10.1016/j.isci.2022.105437.
[PMID] 36388972.
2022
Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood-brain barrier integrity.
Journal of neuroinflammation.
19(1)
[DOI] 10.1186/s12974-022-02533-8.
[PMID] 35761277.
2022
Therapeutic Benefits of Adropin in Aged Mice After Transient Ischemic Stroke via Reduction of Blood-Brain Barrier Damage.
Stroke.
54(1):234-244
[DOI] 10.1161/STROKEAHA.122.039628.
2021
Adropin correlates with aging-related neuropathology in humans and improves cognitive function in aging mice.
NPJ aging and mechanisms of disease.
7(1)
[DOI] 10.1038/s41514-021-00076-5.
[PMID] 34462439.
2021
Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrPC, in type 1 diabetes.
Diabetologia.
[DOI] 10.1007/s00125-021-05501-8.
[PMID] 34274990.
2021
Neurovascular protection by adropin in experimental ischemic stroke through an endothelial nitric oxide synthase-dependent mechanism.
Redox biology.
48
[DOI] 10.1016/j.redox.2021.102197.
[PMID] 34826783.
2021
Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP
Brain, Behavior, and Immunity.
93:141-155
[DOI] 10.1016/j.bbi.2020.12.034.
[PMID] 33422638.
2021
Role of BET Proteins in Inflammation and CNS Diseases.
Frontiers in molecular biosciences.
8
[DOI] 10.3389/fmolb.2021.748449.
[PMID] 34604312.
2020
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19.
Cell metabolism.
32(6):1041-1051.e6
[DOI] 10.1016/j.cmet.2020.11.005.
[PMID] 33207244.
2020
Genetic Deletion or Pharmacological Inhibition of Cyclooxygenase-2 Reduces Blood-Brain Barrier Damage in Experimental Ischemic Stroke.
Frontiers in neurology.
11
[DOI] 10.3389/fneur.2020.00887.
[PMID] 32973660.
2019
Epicatechin-3-Gallate Signaling and Protection against Cardiac Ischemia/Reperfusion Injury.
The Journal of pharmacology and experimental therapeutics.
371(3):663-674
[DOI] 10.1124/jpet.119.260117.
[PMID] 31582423.
2019
Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke.
American journal of physiology. Cell physiology.
316(2):C135-C153
[DOI] 10.1152/ajpcell.00136.2018.
[PMID] 30379577.
2019
Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke.
Neurochemistry international.
127:94-102
[DOI] 10.1016/j.neuint.2019.03.004.
[PMID] 30872008.
2018
Age-Dependent Decrease in Adropin is Associated with Reduced Levels of Endothelial Nitric Oxide Synthase and Increased Oxidative Stress in the Rat Brain.
Aging and disease.
9(2):322-330
[DOI] 10.14336/AD.2017.0523.
[PMID] 29896421.
2018
Protective Effects of L-902,688, a Prostanoid EP4 Receptor Agonist, against Acute Blood-Brain Barrier Damage in Experimental Ischemic Stroke.
Frontiers in neuroscience.
12
[DOI] 10.3389/fnins.2018.00089.
[PMID] 29527151.
2018
Selective degradation of BET proteins with dBET1, a proteolysis-targeting chimera, potently reduces pro-inflammatory responses in lipopolysaccharide-activated microglia.
Biochemical and biophysical research communications.
497(1):410-415
[DOI] 10.1016/j.bbrc.2018.02.096.
[PMID] 29448097.
2017
Selective Inhibition of Janus Kinase 3 Has No Impact on Infarct Size or Neurobehavioral Outcomes in Permanent Ischemic Stroke in Mice.
Frontiers in neurology.
8
[DOI] 10.3389/fneur.2017.00363.
[PMID] 28790974.
2017
Spatiotemporal Changes in P-glycoprotein Levels in Brain and Peripheral Tissues Following Ischemic Stroke in Rats.
Journal of experimental neuroscience.
11
[DOI] 10.1177/1179069517701741.
[PMID] 28469478.
2017
Sustained Neurological Recovery After Stroke in Aged Rats Treated With a Novel Prostacyclin Analog.
Stroke.
48(7):1948-1956
[DOI] 10.1161/STROKEAHA.117.016474.
[PMID] 28588054.
2017
Targeting resolution of neuroinflammation after ischemic stroke with a lipoxin A4 analog: Protective mechanisms and long-term effects on neurological recovery.
Brain and behavior.
7(5)
[DOI] 10.1002/brb3.688.
[PMID] 28523230.
2016
Adropin Reduces Paracellular Permeability of Rat Brain Endothelial Cells Exposed to Ischemia-Like Conditions
Peptides.
81:29-37
[DOI] 10.1016/j.peptides.2016.03.009.
2015
Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke.
Scientific reports.
5
[DOI] 10.1038/srep17956.
[PMID] 26648273.
2014
Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke.
Journal of neurochemistry.
129(1):130-42
[DOI] 10.1111/jnc.12607.
[PMID] 24225006.
2013
Early ischaemic preconditioning requires Akt- and PKA-mediated activation of eNOS via serine1176 phosphorylation.
Cardiovascular research.
97(1):33-43
[DOI] 10.1093/cvr/cvs287.
[PMID] 22977010.
2013
Fast gated EPR imaging of the beating heart: spatiotemporally resolved 3D imaging of free-radical distribution during the cardiac cycle.
Magnetic resonance in medicine.
69(2):594-601
[DOI] 10.1002/mrm.24250.
[PMID] 22473660.
2013
Fluorometric immunocapture assay for the specific measurement of matrix metalloproteinase-9 activity in biological samples: application to brain and plasma from rats with ischemic stroke.
Molecular brain.
6
[DOI] 10.1186/1756-6606-6-14.
[PMID] 23522154.
2012
Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species.
Free radical biology & medicine.
52(2):348-56
[DOI] 10.1016/j.freeradbiomed.2011.10.491.
[PMID] 22100972.
2008
Combination of HSCCC and Sephadex LH-20 methods An approach to isolation and purification of the main individual theaflavins from black tea.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
861(1):140-4
[PMID] 18063426.
2008
Identification of a PKCepsilon-dependent regulation of myocardial contraction by epicatechin-3-gallate.
American journal of physiology. Heart and circulatory physiology.
294(1):H345-53
[PMID] 17951366.
2008
Regulation of inositol 1,4,5-trisphosphate receptor-mediated calcium release by the Na/K-ATPase in cultured renal epithelial cells.
The Journal of biological chemistry.
283(2):1128-36
[PMID] 17993456.
2007
Ouabain triggers preconditioning through activation of the Na+,K+-ATPase signaling cascade in rat hearts.
Cardiovascular research.
73(3):488-96
[PMID] 17157283.
Grants
Jun 2023
ACTIVE
Role of RIPK2 in the neuroinflammatory response to ischemic stroke
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2022
ACTIVE
Targeting RIPK2 to modulate neuroinflammation and improve ischemic stroke outcomes
Role: Co-Investigator
Funding: AMER HEART ASSOCIATION
Jul 2019
ACTIVE
Multi-pronged Approach to Recalibrating the Inflammatory Cascade in Ischemic Stroke with BET blockade
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Sep 2018
– May 2023
Neurovascular Protection by Adropin in Ischemic Stroke
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Sep 2017
– Aug 2019
Neurovascular Protection by Adropin in Ischemic Stroke
Role: Other
Funding: NATL INST OF HLTH NINDS
Contact Details
Phones:
- Business:
- (352) 273-6764
Emails:
- Business:
- changjunyang@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100244
GAINESVILLE FL 32610 - Business Street:
-
1149 SOUTH NEWELL DR ROOM L2-154
GAINESVILLE FL 326110001