Maurice S Swanson,
Professor And Associate Program Director
Department:
Molecular Genetics & Microbiology
Business Phone:
(352) 273-8076
Business Email:
mswanson@ufl.edu
About Maurice S Swanson
Fun Fact: I love to snow ski and play ice hockey.
Our research group focuses on how RNA processing is controlled during mammalian development and how this regulation is disrupted in neurological and neuromuscular diseases. More than half of the human genome is comprised of repetitive elements, including interspersed and tandem repeats, and more than 60 hereditary diseases are caused by the expansion of short tandem repeats (STRs). We investigate the functions of these genomic elements using a wide array of biochemical (e.g., transcriptomics, proteomics) and genetic (e.g., gene knockout and knockin models) strategies. Additionally, we study how RNA binding proteins (RBPs) interact with various RNA structures using global analysis of RBP binding sites, the functions of nuclear RNA foci (biomolecular condensates) generated by pathogenic STR expansions, and how RNA-based mechanisms promote mammalian tissue regeneration. Finally, we are developing novel cell and mouse models to test therapeutic strategies designed to block the toxicity of repetitive element mutations.
Related Links:
Teaching Profile
Courses Taught
2018,2022-2024
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2016-2018
GMS6290 Genetics/Genomics Program Graduate Seminar
2014-2015
BCH6415 Advanced Molecular and Cell Biology
2013-2014
GMS6001 Fundamentals of Biomedical Sciences I
2013
BCH7410 Advanced Gene Regulation
2021
GMS5905 Special Topics in Biomedical Sciences
Research Profile
Areas of Interest
- Aging
- Developmental regulation of RNA processing
- Genetics of Neurological diseases
- Mammalian genome repetitive elements
- Mechanisms of Regeneration
- Myotonic Dystrophy
- Neurological disorders
- RNA binding proteins
Publications
Academic Articles
2024
C9orf72 expansion creates the unstable folate-sensitive fragile site FRA9A
NAR Molecular Medicine.
[DOI] 10.1093/narmme/ugae019.
2024
C9orf72 expansion creates the unstable folate-sensitive fragile site FRA9A.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.10.26.620312.
[PMID] 39569145.
2024
Lineage-specific splicing regulation of MAPT gene in the primate brain.
Cell genomics.
4(6)
[DOI] 10.1016/j.xgen.2024.100563.
[PMID] 38772368.
2024
MBNL deficiency in motor neurons disrupts neuromuscular junction maintenance and gait coordination.
Brain : a journal of neurology.
[DOI] 10.1093/brain/awae336.
[PMID] 39460437.
2024
Spaceflight effects on human vascular smooth muscle cell phenotype and function
npj Microgravity.
10(1)
[DOI] 10.1038/s41526-024-00380-w.
[PMID] 38548798.
2024
Spiny mice are primed but fail to regenerate volumetric skeletal muscle loss injuries.
Skeletal muscle.
14(1)
[DOI] 10.1186/s13395-024-00358-y.
[PMID] 39468576.
2024
Therapeutic targeting of RNA for neurological and neuromuscular disease
Genes & Development.
[DOI] 10.1101/gad.351612.124.
[PMID] 39142832.
2023
Autistic traits in myotonic dystrophy type 1 due to MBNL inhibition and RNA mis-splicing.
Research square.
[DOI] 10.21203/rs.3.rs-3221704/v1.
[PMID] 37645891.
2023
Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1.
Brain : a journal of neurology.
146(10):4217-4232
[DOI] 10.1093/brain/awad148.
[PMID] 37143315.
2023
N6-methyladenosine in 7SK small nuclear RNA underlies RNA polymerase II transcription regulation.
Molecular cell.
83(21):3818-3834.e7
[DOI] 10.1016/j.molcel.2023.09.020.
[PMID] 37820733.
2022
Myotonic dystrophy type 1 embryonic stem cells show decreased myogenic potential, increased CpG methylation at the DMPK locus and RNA mis-splicing
Biology Open.
11(1)
[DOI] 10.1242/bio.058978.
[PMID] 35019138.
2022
The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians
PLOS Biology.
20(4)
[DOI] 10.1371/journal.pbio.3001615.
[PMID] 35476669.
2021
Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2020.04.10.029454.
[PMID] 33880475.
2021
Generation of a Novel SARS-CoV-2 Sub-genomic RNA Due to the R203K/G204R Variant in Nucleocapsid: Homologous Recombination has Potential to Change SARS-CoV-2 at Both Protein and RNA Level.
Pathogens & immunity.
6(2):27-49
[DOI] 10.20411/pai.v6i2.460.
[PMID] 34541432.
2021
RNA structure probing to characterize RNA–protein interactions on low abundance pre-mRNA in living cells
RNA.
27(3):343-358
[DOI] 10.1261/rna.077263.120.
[PMID] 33310817.
2020
Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge.
Current biology : CB.
30(14):2651-2664.e5
[DOI] 10.1016/j.cub.2020.04.085.
[PMID] 32470361.
2020
HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy.
Proceedings of the National Academy of Sciences of the United States of America.
117(10):5472-5477
[DOI] 10.1073/pnas.1907297117.
[PMID] 32086392.
2020
Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood
Nature Communications.
11(1)
[DOI] 10.1038/s41467-020-15962-x.
[PMID] 32332745.
2020
The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1
Nature Biomedical Engineering.
5(2):157-168
[DOI] 10.1038/s41551-020-00607-7.
[PMID] 32929188.
2020
UTteR control through miRs: fine-tuning ATXN1 levels to prevent ataxia
Genes & Development.
34(17-18):1107-1109
[DOI] 10.1101/gad.343020.120.
[PMID] 32873576.
2019
Cell-type-specific dysregulation of RNA alternative splicing in short tandem repeat mouse knockin models of myotonic dystrophy.
Genes & development.
33(23-24):1635-1640
[DOI] 10.1101/gad.328963.119.
[PMID] 31624084.
2019
Methylphenidate Attenuates the Cognitive and Mood Alterations Observed in Mbnl2 Knockout Mice and Reduces Microglia Overexpression.
Cerebral cortex (New York, N.Y. : 1991).
29(7):2978-2997
[DOI] 10.1093/cercor/bhy164.
[PMID] 30060068.
2019
Short Tandem Repeat Expansions and RNA-Mediated Pathogenesis in Myotonic Dystrophy.
International journal of molecular sciences.
20(13)
[DOI] 10.3390/ijms20133365.
[PMID] 31323950.
2018
Altered levels of the splicing factor muscleblind modifies cerebral cortical function in mouse models of myotonic dystrophy.
Neurobiology of disease.
112:35-48
[DOI] 10.1016/j.nbd.2018.01.003.
[PMID] 29331264.
2018
Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.
Scientific reports.
8(1)
[DOI] 10.1038/s41598-018-21371-4.
[PMID] 29511296.
2018
Intron retention induced by microsatellite expansions as a disease biomarker.
Proceedings of the National Academy of Sciences of the United States of America.
115(16):4234-4239
[DOI] 10.1073/pnas.1716617115.
[PMID] 29610297.
2018
MBNL splicing activity depends on RNA binding site structural context.
Nucleic acids research.
46(17):9119-9133
[DOI] 10.1093/nar/gky565.
[PMID] 29955876.
2018
Myotonic Dystrophy and Developmental Regulation of RNA Processing.
Comprehensive Physiology.
8(2):509-553
[DOI] 10.1002/cphy.c170002.
[PMID] 29687899.
2018
Precise temporal regulation of alternative splicing during neural development.
Nature communications.
9(1)
[DOI] 10.1038/s41467-018-04559-0.
[PMID] 29875359.
2018
STRring up Cancer with lncRNA.
Molecular cell.
72(3):399-401
[DOI] 10.1016/j.molcel.2018.10.026.
[PMID] 30388407.
2017
Aberrant Myokine Signaling in Congenital Myotonic Dystrophy.
Cell reports.
21(5):1240-1252
[DOI] 10.1016/j.celrep.2017.10.018.
[PMID] 29091763.
2017
Disrupted prenatal RNA processing and myogenesis in congenital myotonic dystrophy.
Genes & development.
31(11):1122-1133
[DOI] 10.1101/gad.300590.117.
[PMID] 28698297.
2017
Downregulation of the Glial GLT1 Glutamate Transporter and Purkinje Cell Dysfunction in a Mouse Model of Myotonic Dystrophy.
Cell reports.
19(13):2718-2729
[DOI] 10.1016/j.celrep.2017.06.006.
[PMID] 28658620.
2017
Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9.
Cell.
170(5):899-912.e10
[DOI] 10.1016/j.cell.2017.07.010.
[PMID] 28803727.
2017
Impeding Transcription of Expanded Microsatellite Repeats by Deactivated Cas9.
Molecular cell.
68(3):479-490.e5
[DOI] 10.1016/j.molcel.2017.09.033.
[PMID] 29056323.
2017
RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2.
Neuron.
95(6):1292-1305.e5
[DOI] 10.1016/j.neuron.2017.08.039.
[PMID] 28910618.
2017
Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype.
Acta neuropathologica communications.
5(1)
[DOI] 10.1186/s40478-017-0502-0.
[PMID] 29237481.
2017
SFMetaDB: a comprehensive annotation of mouse RNA splicing factor RNA-Seq datasets.
Database : the journal of biological databases and curation.
2017
[DOI] 10.1093/database/bax071.
[PMID] 29220461.
2016
Distal Alternative Last Exons Localize mRNAs to Neural Projections.
Molecular cell.
61(6):821-33
[DOI] 10.1016/j.molcel.2016.01.020.
[PMID] 26907613.
2016
RNA mis-splicing in disease.
Nature reviews. Genetics.
17(1):19-32
[DOI] 10.1038/nrg.2015.3.
[PMID] 26593421.
2016
Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy.
Nature communications.
7
[DOI] 10.1038/ncomms11067.
[PMID] 27063795.
2016
Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype.
Acta neuropathologica communications.
4(1)
[DOI] 10.1186/s40478-016-0393-5.
[PMID] 27863507.
2015
Abnormal splicing switch of DMD’s penultimate exon compromises muscle fibre maintenance in myotonic dystrophy.
Nature communications.
6
[DOI] 10.1038/ncomms8205.
[PMID] 26018658.
2015
Genome modification leads to phenotype reversal in human myotonic dystrophy type 1 induced pluripotent stem cell-derived neural stem cells.
Stem cells (Dayton, Ohio).
33(6):1829-38
[DOI] 10.1002/stem.1970.
[PMID] 25702800.
2015
Global insights into alternative polyadenylation regulation.
RNA biology.
12(6):597-602
[DOI] 10.1080/15476286.2015.1040974.
[PMID] 25892335.
2015
MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain.
Cell reports.
12(7):1159-68
[DOI] 10.1016/j.celrep.2015.07.029.
[PMID] 26257173.
2015
MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response.
Nature communications.
6
[DOI] 10.1038/ncomms10084.
[PMID] 26670661.
2015
Muscleblind-like 1 is required for normal heart valve development in vivo.
BMC developmental biology.
15
[DOI] 10.1186/s12861-015-0087-4.
[PMID] 26472242.
2015
Rectifying RNA splicing errors in hereditary neurodegenerative disease.
Proceedings of the National Academy of Sciences of the United States of America.
112(9):2637-8
[DOI] 10.1073/pnas.1500976112.
[PMID] 25691745.
2014
Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease.
Molecular cell.
56(2):311-322
[DOI] 10.1016/j.molcel.2014.08.027.
[PMID] 25263597.
2014
RNA-binding protein misregulation in microsatellite expansion disorders.
Advances in experimental medicine and biology.
825:353-88
[DOI] 10.1007/978-1-4939-1221-6_10.
[PMID] 25201111.
2014
RNA-protein interactions in unstable microsatellite diseases.
Brain research.
1584:3-14
[DOI] 10.1016/j.brainres.2014.03.039.
[PMID] 24709120.
2013
Compound loss of muscleblind-like function in myotonic dystrophy.
EMBO molecular medicine.
5(12):1887-900
[DOI] 10.1002/emmm.201303275.
[PMID] 24293317.
2013
Generation of neural cells from DM1 induced pluripotent stem cells as cellular model for the study of central nervous system neuropathogenesis.
Cellular reprogramming.
15(2):166-77
[DOI] 10.1089/cell.2012.0086.
[PMID] 23550732.
2013
Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour.
Brain : a journal of neurology.
136(Pt 3):957-70
[DOI] 10.1093/brain/aws367.
[PMID] 23404338.
2013
Prediction of clustered RNA-binding protein motif sites in the mammalian genome.
Nucleic acids research.
41(14):6793-807
[DOI] 10.1093/nar/gkt421.
[PMID] 23685613.
2013
Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice.
Human molecular genetics.
22(17):3547-58
[DOI] 10.1093/hmg/ddt209.
[PMID] 23660517.
2013
Splicing biomarkers of disease severity in myotonic dystrophy.
Annals of neurology.
74(6):862-72
[DOI] 10.1002/ana.23992.
[PMID] 23929620.
2012
Muscleblind-like 1 knockout mice reveal novel splicing defects in the myotonic dystrophy brain.
PloS one.
7(3)
[DOI] 10.1371/journal.pone.0033218.
[PMID] 22427994.
2012
Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy.
Neuron.
75(3):437-50
[DOI] 10.1016/j.neuron.2012.05.029.
[PMID] 22884328.
2012
Myosin light chain phosphorylation is critical for adaptation to cardiac stress.
Circulation.
126(22):2575-88
[DOI] 10.1161/CIRCULATIONAHA.112.116202.
[PMID] 23095280.
2011
Developments in RNA splicing and disease.
Cold Spring Harbor perspectives in biology.
3(1)
[DOI] 10.1101/cshperspect.a000778.
[PMID] 21084389.
2011
Non-ATG-initiated translation directed by microsatellite expansions.
Proceedings of the National Academy of Sciences of the United States of America.
108(1):260-5
[DOI] 10.1073/pnas.1013343108.
[PMID] 21173221.
2011
Silence is not always golden.
Genetic testing and molecular biomarkers.
15(7-8)
[DOI] 10.1089/gtmb.2011.1521.
[PMID] 21762002.
2010
[Double the trouble: bidirectional expression of the SCA8 CAG/CTG expansion mutation – evidence for RNA and protein gain of function effects].
Rinsho shinkeigaku = Clinical neurology.
50(11):982-3
[PMID] 21921535.
2010
Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy.
Nature structural & molecular biology.
17(2):187-93
[DOI] 10.1038/nsmb.1720.
[PMID] 20098426.
2010
Partners in crime: bidirectional transcription in unstable microsatellite disease.
Human molecular genetics.
19(R1):R77-82
[DOI] 10.1093/hmg/ddq132.
[PMID] 20368264.
2009
Mechanisms of RNA-mediated disease.
The Journal of biological chemistry.
284(12):7419-23
[DOI] 10.1074/jbc.R800025200.
[PMID] 18957432.
2009
Pathogenic RNAs in microsatellite expansion disease.
Neuroscience letters.
466(2):99-102
[DOI] 10.1016/j.neulet.2009.07.079.
[PMID] 19647781.
2009
RNA gain-of-function in spinocerebellar ataxia type 8.
PLoS genetics.
5(8)
[DOI] 10.1371/journal.pgen.1000600.
[PMID] 19680539.
2009
Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy.
Human molecular genetics.
18(8):1471-81
[DOI] 10.1093/hmg/ddp058.
[PMID] 19223393.
2007
Correction of ClC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy.
The Journal of clinical investigation.
117(12):3952-7
[PMID] 18008009.
2007
Essential role for Dicer during skeletal muscle development.
Developmental biology.
311(2):359-68
[PMID] 17936265.
2007
Fragile X tremor/ataxia syndrome: blame the messenger!
Neuron.
55(4):535-7
[PMID] 17698005.
2007
Muscle chloride channel dysfunction in two mouse models of myotonic dystrophy.
The Journal of general physiology.
129(1):79-94
[PMID] 17158949.
2007
Muscleblind isoforms are functionally distinct and regulate alpha-actinin splicing.
Differentiation; research in biological diversity.
75(5):427-40
[PMID] 17309604.
2007
Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs.
Nucleic acids research.
35(16):5474-86
[PMID] 17702765.
2006
Constraints on the structure of (CUG)97 RNA from magic-angle-spinning solid-state NMR spectroscopy.
Angewandte Chemie (International ed. in English).
45(34):5620-3
[PMID] 16856200.
2006
Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy.
Human molecular genetics.
15(13):2087-97
[PMID] 16717059.
2006
MicroRNAs in mammalian development and tumorigenesis.
Birth defects research. Part C, Embryo today : reviews.
78(2):172-9
[PMID] 16847882.
2006
Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy.
Proceedings of the National Academy of Sciences of the United States of America.
103(31):11748-53
[PMID] 16864772.
2005
Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy.
Journal of cell science.
118(Pt 13):2923-33
[PMID] 15961406.
2005
Dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development.
Developmental dynamics : an official publication of the American Association of Anatomists.
233(3):783-93
[PMID] 15830352.
2005
Nuclear RNA foci in the heart in myotonic dystrophy.
Circulation research.
97(11):1152-5
[PMID] 16254211.
2005
Yeast mRNA Poly(A) tail length control can be reconstituted in vitro in the absence of Pab1p-dependent Poly(A) nuclease activity.
The Journal of biological chemistry.
280(26):24532-8
[PMID] 15894541.
2004
(1)H, (15)N and (13)C chemical shift assignments of RNA repeats binding protein — CUGBP1ab.
Journal of biomolecular NMR.
30(3):371-2
[PMID] 15756469.
2004
Identification of NH…N hydrogen bonds by magic angle spinning solid state NMR in a double-stranded RNA associated with myotonic dystrophy.
Nucleic acids research.
32(3):1177-83
[PMID] 14973225.
2004
Muscleblind proteins regulate alternative splicing.
The EMBO journal.
23(15):3103-12
[PMID] 15257297.
2004
Myotonic dystrophy type 1 is associated with nuclear foci of mutant RNA, sequestration of muscleblind proteins and deregulated alternative splicing in neurons.
Human molecular genetics.
13(24):3079-88
[PMID] 15496431.
2004
Small molecule regulators of protein arginine methyltransferases.
The Journal of biological chemistry.
279(23):23892-9
[PMID] 15056663.
2004
Toxic RNA in the nucleus: unstable microsatellite expression in neuromuscular disease.
Progress in molecular and subcellular biology.
35:57-77
[PMID] 15113079.
2003
A muscleblind knockout model for myotonic dystrophy.
Science (New York, N.Y.).
302(5652):1978-80
[PMID] 14671308.
2003
Developmental expression of mouse muscleblind genes Mbnl1, Mbnl2 and Mbnl3.
Gene expression patterns : GEP.
3(4):459-62
[PMID] 12915312.
2003
Ribonuclear inclusions in skeletal muscle in myotonic dystrophy types 1 and 2.
Annals of neurology.
54(6):760-8
[PMID] 14681885.
2002
Dual requirement for yeast hnRNP Nab2p in mRNA poly(A) tail length control and nuclear export.
The EMBO journal.
21(7):1800-10
[PMID] 11927564.
2001
Identification of an autoimmune serum containing antibodies against the Barr body.
Proceedings of the National Academy of Sciences of the United States of America.
98(15):8703-8
[PMID] 11438711.
2001
Muscleblind localizes to nuclear foci of aberrant RNA in myotonic dystrophy types 1 and 2.
Human molecular genetics.
10(19):2165-70
[PMID] 11590133.
2000
A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase II.
Genetics.
154(2):557-71
[PMID] 10655211.
2000
HuR binding to cytoplasmic mRNA is perturbed by heat shock.
Proceedings of the National Academy of Sciences of the United States of America.
97(7):3073-8
[PMID] 10737787.
2000
Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy.
The EMBO journal.
19(17):4439-48
[PMID] 10970838.
1999
hnRNP complexes: composition, structure, and function.
Current opinion in cell biology.
11(3):363-71
[PMID] 10395553.
1999
Preparation of heterogeneous nuclear ribonucleoprotein complexes.
Methods in molecular biology (Clifton, N.J.).
118:299-308
[PMID] 10549532.
1999
Visualization of double-stranded RNAs from the myotonic dystrophy protein kinase gene and interactions with CUG-binding protein.
Nucleic acids research.
27(17):3534-42
[PMID] 10446244.
1998
Control of cleavage site selection during mRNA 3′ end formation by a yeast hnRNP.
The EMBO journal.
17(24):7454-68
[PMID] 9857200.
1998
Expression of Legionella pneumophila virulence traits in response to growth conditions.
Infection and immunity.
66(7):3029-34
[PMID] 9632562.
1998
The Gcn4p activation domain interacts specifically in vitro with RNA polymerase II holoenzyme, TFIID, and the Adap-Gcn5p coactivator complex.
Molecular and cellular biology.
18(3):1711-24
[PMID] 9488488.
1997
Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice.
Proceedings of the National Academy of Sciences of the United States of America.
94(24):13221-6
[PMID] 9371827.
1996
A plant viral coat protein RNA binding consensus sequence contains a crucial arginine.
The EMBO journal.
15(18):5077-84
[PMID] 8890181.
1996
Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy.
Nucleic acids research.
24(22):4407-14
[PMID] 8948631.
1996
Myotonic dystrophy: discussion of molecular mechanism.
Cold Spring Harbor symposia on quantitative biology.
61:607-14
[PMID] 9246487.
1994
Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae.
The Journal of cell biology.
127(5):1173-84
[PMID] 7962083.
1994
The effect of weight-loss on estimated breast-cancer risk and sex-hormone levels.
Oncology reports.
1(3):613-7
[PMID] 21607413.
1993
NAB2: a yeast nuclear polyadenylated RNA-binding protein essential for cell viability.
Molecular and cellular biology.
13(5):2730-41
[PMID] 8474438.
1993
PUB1 is a major nuclear and cytoplasmic polyadenylated RNA-binding protein in Saccharomyces cerevisiae.
Molecular and cellular biology.
13(10):6102-13
[PMID] 8413212.
1993
The human hnRNP M proteins: identification of a methionine/arginine-rich repeat motif in ribonucleoproteins.
Nucleic acids research.
21(3):439-46
[PMID] 8441656.
1992
SPT4, SPT5 and SPT6 interactions: effects on transcription and viability in Saccharomyces cerevisiae.
Genetics.
132(2):325-36
[PMID] 1330823.
1991
Improved xenograft survival with continuous infusion deoxyspergualin and RATG.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
4(1):59-67
[PMID] 1863589.
1991
In vivo detection of snRNP-rich organelles in the nuclei of mammalian cells.
The EMBO journal.
10(7):1863-73
[PMID] 1710980.
1991
SPT5, an essential gene important for normal transcription in Saccharomyces cerevisiae, encodes an acidic nuclear protein with a carboxy-terminal repeat.
Molecular and cellular biology.
11(8)
[PMID] 2072920.
1990
Heterogeneous nuclear ribonucleoprotein complexes.
Molecular biology reports.
14(2-3):79-82
[PMID] 1972976.
1990
Purification and characterization of proteins of heterogeneous nuclear ribonucleoprotein complexes by affinity chromatography.
Methods in enzymology.
181:326-31
[PMID] 2143257.
1990
Reevaluation of total-lymphoid irradiation and cyclosporine therapy in the Syrian hamster-to-Lewis rat cardiac xenograft model.
Transplantation.
49(3):639-41
[PMID] 2180153.
1990
SPT6, an essential gene that affects transcription in Saccharomyces cerevisiae, encodes a nuclear protein with an extremely acidic amino terminus.
Molecular and cellular biology.
10(9):4935-41
[PMID] 2201908.
1990
The asymptomatic patient with suspected myocardial contusion.
American journal of surgery.
160(6):638-42; discussion 642
[PMID] 2252127.
1989
A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts.
The Journal of cell biology.
109(6 Pt 1):2575-87
[PMID] 2687284.
1989
Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.
Proceedings of the National Academy of Sciences of the United States of America.
86(24):9788-92
[PMID] 2557628.
1989
RNA-binding proteins as developmental regulators.
Genes & development.
3(4):431-7
[PMID] 2470643.
1988
Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA-binding specificities.
Molecular and cellular biology.
8(5):2237-41
[PMID] 3386636.
1988
Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation.
Trends in biochemical sciences.
13(3):86-91
[PMID] 3072706.
1988
RNA binding specificity of hnRNP proteins: a subset bind to the 3′ end of introns.
The EMBO journal.
7(11):3519-29
[PMID] 3208740.
1987
Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins.
Molecular and cellular biology.
7(5):1731-9
[PMID] 3110598.
1986
Molecular cloning of cDNA for the nuclear ribonucleoprotein particle C proteins: a conserved gene family.
Proceedings of the National Academy of Sciences of the United States of America.
83(7):2007-11
[PMID] 3457372.
1986
mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence.
Molecular and cellular biology.
6(8):2932-43
[PMID] 3537727.
1985
Developmental expression of nuclear genes that encode mitochondrial proteins: insect cytochromes c.
Proceedings of the National Academy of Sciences of the United States of America.
82(7):1964-8
[PMID] 2984675.
Grants
Aug 2024
ACTIVE
Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jan 2024
ACTIVE
The molecular basis of 7SK RNA methylation in non-small cell lung cancer
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Sep 2023
ACTIVE
Understanding and targeting common mechanisms of myotonic dystrophy types 1 and 2 using novel repeat expansion mouse models
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Sep 2023
– Jul 2024
Mouse Dmpk CTG expansion knock in models for myotonic dystrophy (MDA 1070134)
Role: Other
Funding: MUSCULAR DYSTROPHY ASSO
Jan 2023
ACTIVE
Regenerative failure in myotonic dystrophy: pathomechanisms and insights from a novel model of improved regeneration
Role: Other
Funding: MYOTONIC DYSTROPHY FOU
Jan 2023
ACTIVE
Therapeutic strategies for microsatellite expansion diseases using RNA-targeting
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN DIEGO
via NATL INST OF HLTH NINDS
Aug 2021
– Aug 2022
Mouse humanized models for myotonic dystrophy type 1 for therapy development
Role: Principal Investigator
Funding: KATE THERAPEUTICS
Jul 2021
– Sep 2023
Brain Choroid Plexus Dysregulation and Cerebral Atrophy in DM1
Role: Other
Funding: MYOTONIC DYSTROPHY FOU
Jan 2020
– Jan 2023
Provenance Initiatives Fund at the Center for NeuroGenetics
Role: Co-Investigator
Funding: UF FOUNDATION
Jul 2019
ACTIVE
RNA Processing-Mediated Mechanisms of CNS Dysfunction in Myotonic Dystrophy
Role: Faculty
Funding: NATL INST OF HLTH NINDS
Jun 2019
– Aug 2019
International Myotonic Dystrophy Consortium Meeting IDMC-12
Role: Principal Investigator
Funding: MUSCULAR DYSTROPHY ASSO
Sep 2018
– Aug 2024
Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center
Role: Principal Investigator
Funding: UNIV OF ROCHESTER
via NATL INST OF HLTH NINDS
Sep 2018
– Aug 2023
Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center (Administrative Core)
Role: Principal Investigator
Funding: UNIV OF ROCHESTER
via NATL INST OF HLTH NINDS
Sep 2018
– Aug 2023
Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center (Project 3 Preclinical Model and Therapies for DM2).
Role: Principal Investigator
Funding: UNIV OF ROCHESTER
via NATL INST OF HLTH NINDS
Sep 2018
– Aug 2023
Senator Paul D. Wellstone Muscular dystrophy Speciallzed Research Center (Project 2 Disease Progress and Biomarkers)
Role: Principal Investigator
Funding: UNIV OF ROCHESTER
via NATL INST OF HLTH NINDS
Feb 2018
– Jan 2021
Pre-mRNA Misprocessing in Myotonic Dystrophy and Amyotrophic Lateral Sclerosis
Role: Other
Funding: MUSCULAR DYSTROPHY ASSO
Jan 2018
– Dec 2019
Congenital myotonic dystrophy:pathomechanism and therapeutic development
Role: Other
Funding: WYCK FOUNDATION
Sep 2017
– May 2022
Therapeutic strategies for microsatellite expansion diseases using RNA-targeting CRISPR/Cas
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN DIEGO
via NATL INST OF HLTH NINDS
Aug 2017
– Apr 2022
Determining the factors that control dose-dependent splicing regulation by a master regulator
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Feb 2017
– Jan 2020
Novel Mouse Knockin Models for Myotonic Dystrophy
Role: Principal Investigator
Funding: MUSCULAR DYSTROPHY ASSO
Aug 2016
– Jun 2022
Molecular Characterization of ALS/FTD in a novel C9orf72 BAC mouse model.
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Feb 2016
– Jan 2018
Myotonic Dystrophy Type 2: Mouse Models, pathomechanism and therapy
Role: Principal Investigator
Funding: WYCK FOUNDATION
Jan 2015
– Jan 2018
MBI Research Program MGOLD2
Role: Principal Investigator
Funding: UF FOUNDATION
Sep 2013
– Jun 2019
Myotonic Dystrophy: Molecular Pathophysiology and CNS Effects
Role: Project Manager
Funding: NATL INST OF HLTH NINDS
Aug 2013
– Jul 2016
Circadian Clock Dysregulation in Myotonic Dystrophy
Role: Principal Investigator
Funding: MUSCULAR DYSTROPHY ASSO
Jul 2013
– Jun 2018
Research Program MGOLD project 2
Role: Principal Investigator
Funding: UF FOUNDATION
Aug 2010
– Jun 2016
RNA Dominance in Human Disease
Role: Principal Investigator
Funding: NATL INST OF HLTH
Jul 2006
– Sep 2024
BRAIN AND SPINAL CORD INJURY RESEARCH
Role: Project Manager
Funding: FL DEPT OF HLTH
Education
PhD
1979
·
University of California Berkeley
MA
1976
·
University of California Santa Barbara
Contact Details
Phones:
- Business:
- (352) 273-8076
Emails:
- Business:
- mswanson@ufl.edu
Addresses:
- Business Mailing:
-
2033 MOWRY RD
GAINESVILLE FL 32610 - Business Street:
-
Cancer Genetics Research Complex
College of Medicine, 2033 Mowry Rd
DEPT. OF MOLECULAR GENETICS AND MICROBIOLOGY
GAINESVILLE FL 326103610