Maurice S Swanson,
Professor And Associate Program Director
About Maurice S Swanson
Fun Fact: I love to snow ski and play ice hockey.
Our research group focuses on how RNA processing is controlled during mammalian development and how this regulation is disrupted in neurological and neuromuscular diseases. More than half of the human genome is comprised of repetitive elements, including interspersed and tandem repeats, and more than 60 hereditary diseases are caused by the expansion of short tandem repeats (STRs). We investigate the functions of these genomic elements using a wide array of biochemical (e.g., transcriptomics, proteomics) and genetic (e.g., gene knockout and knockin models) strategies. Additionally, we study how RNA binding proteins (RBPs) interact with various RNA structures using global analysis of RBP binding sites, the functions of nuclear RNA foci (biomolecular condensates) generated by pathogenic STR expansions, and how RNA-based mechanisms promote mammalian tissue regeneration. Finally, we are developing novel cell and mouse models to test therapeutic strategies designed to block the toxicity of repetitive element mutations.
Teaching Profile
Research Profile
- Aging
- Developmental regulation of RNA processing
- Genetics of Neurological diseases
- Mammalian genome repetitive elements
- Mechanisms of Regeneration
- Myotonic Dystrophy
- Neurological disorders
- RNA binding proteins
0000-0001-6245-5367
Publications
Grants
Education
Contact Details
- Business:
- (352) 273-8076
- Business:
- mswanson@ufl.edu
- Business Mailing:
-
2033 MOWRY RD
GAINESVILLE FL 32610 - Business Street:
-
Cancer Genetics Research Complex
College of Medicine, 2033 Mowry Rd
DEPT. OF MOLECULAR GENETICS AND MICROBIOLOGY
GAINESVILLE FL 326103610