Matthew R Sarkisian,
Associate Professor, Program Director MS In Neuroscience Graduate Program
Department:
Department of Neuroscience
Business Phone:
(352) 273-5534
Business Email:
msarkisian@ufl.edu
Teaching Profile
Courses Taught
2011-2023
GMS6021 Organization and Development of the Nervous System
2017-2021
GMS6705 Functional Human Neuroanatomy
2019,2021-2023,2023
GMS6013 Developmental Genetics
2018
GMS7980 Research for Doctoral Dissertation
2015
GMS7794 Neuroscience Seminar
2011,2021-2023
GMS6073 Disorders of the Developing Nervous System
2010
GMS7795 Special Topics in Neuroscience
2022-2023
GMS6007 Fundamentals of Neuroscience
2021-2023
GMS6029 Brain Journal Club
2022-2023
GMS6905 Independent Studies in Medical Sciences
2022-2023
GMS6701 Functional and Comparative Neuroanatomy for Professionals
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-0566-6480
Publications
2022
Slow-Cycling Cells in Glioblastoma: A Specific Population in the Cellular Mosaic of Cancer Stem Cells.
Cancers.
14(5)
[DOI] 10.3390/cancers14051126.
[PMID] 35267434.
2022
Tumor Treating Fields Suppression of Ciliogenesis Enhances Temozolomide Toxicity.
Frontiers in oncology.
12
[DOI] 10.3389/fonc.2022.837589.
[PMID] 35359402.
2021
HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells.
Cancers.
13(7)
[DOI] 10.3390/cancers13071644.
[PMID] 33915983.
2020
CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas.
Proceedings of the National Academy of Sciences of the United States of America.
117(2):1129-1138
[DOI] 10.1073/pnas.1910856117.
[PMID] 31879345.
2019
Emerging Roles of Primary Cilia in Glioma.
Frontiers in cellular neuroscience.
13
[DOI] 10.3389/fncel.2019.00055.
[PMID] 30842728.
2019
In utero electroporation-based translating ribosome affinity purification identifies age-dependent mRNA expression in cortical pyramidal neurons.
Neuroscience research.
143:44-52
[DOI] 10.1016/j.neures.2018.05.006.
[PMID] 29857015.
2018
Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles.
Cilia.
7
[DOI] 10.1186/s13630-018-0060-5.
[PMID] 30410731.
2018
Infiltrative and drug-resistant slow-cycling cells support metabolic heterogeneity in glioblastoma.
The EMBO journal.
37(23)
[DOI] 10.15252/embj.201798772.
[PMID] 30322894.
2018
Personalized Tumor RNA Loaded Lipid-Nanoparticles Prime the Systemic and Intratumoral Milieu for Response to Cancer Immunotherapy.
Nano letters.
18(10):6195-6206
[DOI] 10.1021/acs.nanolett.8b02179.
[PMID] 30259750.
2016
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
Oncotarget.
7(6):7029-43
[DOI] 10.18632/oncotarget.6854.
[PMID] 26760767.
2016
Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons.
Experimental neurology.
282:119-27
[DOI] 10.1016/j.expneurol.2016.05.015.
[PMID] 27181411.
2016
Neuroanatomical characterization of the cellular and axonal architecture of subcortical band heterotopia in the BXD29-Tlr4lps-2J/J mouse cortex.
Neuroscience.
337:48-65
[DOI] 10.1016/j.neuroscience.2016.08.049.
[PMID] 27595889.
2016
PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide.
Translational oncology.
9(5):392-402
[DOI] 10.1016/j.tranon.2016.08.006.
[PMID] 27661404.
2016
Type 3 Adenylyl Cyclase and Somatostatin Receptor 3 Expression Persists in Aged Rat Neocortical and Hippocampal Neuronal Cilia.
Frontiers in aging neuroscience.
8
[DOI] 10.3389/fnagi.2016.00127.
[PMID] 27303293.
2015
Influences of primary cilia on cortical morphogenesis and neuronal subtype maturation.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.
21(2):136-51
[DOI] 10.1177/1073858414531074.
[PMID] 24740576.
2014
Detection of primary cilia in human glioblastoma.
Journal of neuro-oncology.
117(1):15-24
[DOI] 10.1007/s11060-013-1340-y.
[PMID] 24510433.
2013
Arborization of dendrites by developing neocortical neurons is dependent on primary cilia and type 3 adenylyl cyclase.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
33(6):2626-38
[DOI] 10.1523/JNEUROSCI.2906-12.2013.
[PMID] 23392690.
2013
The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance.
EMBO molecular medicine.
5(8):1196-212
[DOI] 10.1002/emmm.201302827.
[PMID] 23818228.
2012
Abnormal levels of Gadd45alpha in developing neocortex impair neurite outgrowth.
PloS one.
7(9)
[DOI] 10.1371/journal.pone.0044207.
[PMID] 22970179.
2012
Development and distribution of neuronal cilia in mouse neocortex.
The Journal of comparative neurology.
520(4):848-73
[DOI] 10.1002/cne.22793.
[PMID] 22020803.
2012
Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction.
Acta neuropathologica.
123(6):807-23
[DOI] 10.1007/s00401-012-0979-3.
[PMID] 22539017.
2011
Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin.
Neuroscience.
190:398-408
[DOI] 10.1016/j.neuroscience.2011.06.010.
[PMID] 21689730.
2011
Failed cytokinesis of neural progenitors in citron kinase-deficient rats leads to multiciliated neurons.
Cerebral cortex (New York, N.Y. : 1991).
21(2):338-44
[DOI] 10.1093/cercor/bhq099.
[PMID] 20525772.
2010
Discs large 5: a new regulator of Citron kinase localization in developing neocortex: comment on: Chang Y, et al. Cell Cycle 2010; 9:1990-7.
Cell cycle (Georgetown, Tex.).
9(10)
[PMID] 20505324.
2008
Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex.
Neuron.
60(2):273-84
[DOI] 10.1016/j.neuron.2008.09.026.
[PMID] 18957219.
2008
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling.
Proceedings of the National Academy of Sciences of the United States of America.
105(35):13127-32
[DOI] 10.1073/pnas.0804558105.
[PMID] 18728187.
2008
The stumpy gene is required for mammalian ciliogenesis.
Proceedings of the National Academy of Sciences of the United States of America.
105(8):2853-8
[DOI] 10.1073/pnas.0712385105.
[PMID] 18287022.
2008
Trouble making the first move: interpreting arrested neuronal migration in the cerebral cortex.
Trends in neurosciences.
31(2):54-61
[DOI] 10.1016/j.tins.2007.11.009.
[PMID] 18201775.
2007
Citron kinase is required for postnatal neurogenesis in the hippocampus.
Developmental neuroscience.
29(1-2):113-23
[PMID] 17148954.
2007
Genetic determinants of neuronal migration in the cerebral cortex.
Novartis Foundation symposium.
288:45-53; discussion 53
[PMID] 18494251.
2006
MEKK4 signaling regulates filamin expression and neuronal migration.
Neuron.
52(5):789-801
[PMID] 17145501.
2005
Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.
Proceedings of the National Academy of Sciences of the United States of America.
102(10):3846-51
[PMID] 15731347.
2003
Phosphatidylserine receptor is required for clearance of apoptotic cells.
Science (New York, N.Y.).
302(5650):1560-3
[PMID] 14645847.
2002
Citron-kinase, a protein essential to cytokinesis in neuronal progenitors, is deleted in the flathead mutant rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
22(8)
[PMID] 11932363.
2002
Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus.
Epilepsy research.
48(1-2):3-13
[PMID] 11823105.
2001
Altered interneuron development in the cerebral cortex of the flathead mutant.
Cerebral cortex (New York, N.Y. : 1991).
11(8):734-43
[PMID] 11459763.
2001
Animal Models for Human Seizure and Epileptic Activity. Reply.
Epilepsy & behavior : E&B.
2(5):506-507
[PMID] 12609298.
2001
Enhanced auditory reversal learning by genetic activation of protein kinase C in small groups of rat hippocampal neurons.
Brain research. Molecular brain research.
93(2):127-36
[PMID] 11589990.
2001
Overview of the Current Animal Models for Human Seizure and Epileptic Disorders.
Epilepsy & behavior : E&B.
2(3):201-216
[PMID] 12609365.
2000
Protective effects of prenatal choline supplementation on seizure-induced memory impairment.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
20(22)
[PMID] 11069978.
1999
Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development.
Epilepsia.
40(4):394-400
[PMID] 10219263.
1999
Consequences of cortical dysplasia during development in rats.
Epilepsia.
40(5):537-44
[PMID] 10386521.
1999
Consequences of recurrent seizures during early brain development.
Neuroscience.
92(4):1443-54
[PMID] 10426498.
1999
Effects of hyperthermia and continuous hippocampal stimulation on the immature and adult brain.
Brain & development.
21(5):318-25
[PMID] 10413019.
1999
Mossy fiber sprouting after recurrent seizures during early development in rats.
The Journal of comparative neurology.
404(4):537-53
[PMID] 9987996.
1998
A gene essential to brain growth and development maps to the distal arm of rat chromosome 12.
Neuroscience letters.
251(1):5-8
[PMID] 9714451.
1998
Comparison of valproate and phenobarbital treatment after status epilepticus in rats.
Neurology.
51(1):41-8
[PMID] 9674776.
1998
Synaptic reorganization following kainic acid-induced seizures during development.
Brain research. Developmental brain research.
107(2):169-77
[PMID] 9593878.
1997
[Consequences of recurrent seizures during development].
Revista de neurologia.
25(141):749-53
[PMID] 9206603.
1997
Multiple kainic acid seizures in the immature and adult brain: ictal manifestations and long-term effects on learning and memory.
Epilepsia.
38(11):1157-66
[PMID] 9579915.
1997
Seizure-induced glutamate release in mature and immature animals: an in vivo microdialysis study.
Neuroreport.
8(8):2019-23
[PMID] 9223095.
1996
Age-dependent effects of glutamate toxicity in the hippocampus.
Brain research. Developmental brain research.
97(2):178-84
[PMID] 8997502.
1996
Long-term effects of excitatory amino acid antagonists NBQX and MK-801 on the developing brain.
Brain research. Developmental brain research.
95(2):256-62
[PMID] 8874901.
1996
Recurrent seizures in immature rats: effect on auditory and visual discrimination.
Brain research. Developmental brain research.
95(2):283-92
[PMID] 8874904.
Grants
Sep 2022
ACTIVE
UF HEALTH CANCER CENTER PILOT PROJECTS GRANTS FUNDED THROUGHTHE FLORIDA CONSORTIUM OF NATIONAL CANCER INSTITUTE CENTER
Role: Faculty
Funding: UF HEALTH SHANDS HOSPITAL
Aug 2022
ACTIVE
Metabolic interactions between tumor cells and the immunce system in GBM A potential Achilles heel of GBM for novel therapeutics
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2022
ACTIVE
Improving TTFields Efficacy by Altering Ciliogenesis
Role: Principal Investigator
Funding: AMER ASSO FOR CANCER RESEARCH
Jul 2019
– Dec 2021
Enhancing TTFields Therapy for Glioblastoma By Dual Inhibition of HDAC6 and SIRT2
Role: Principal Investigator
Funding: AMER ASSO FOR CANCER RESEARCH
Sep 2018
ACTIVE
Targeting CCR2-expressing myeloid cells to overcome immune checkpoint inhibitor resistance in glioma
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Jun 2018
– Dec 2020
Primary Cilia-Derived ARL13B As a Biomarker and Promoter of?Gliomagenesis
Role: Principal Investigator
Funding: AMER BRAIN TUMOR ASSOCIATION
Jul 2017
– Feb 2019
Effects of Early Hypo- and Hyperthyroidism on Long-term Cortical Circuit Plasticity
Role: Co-Investigator
Funding: AMERICAN THYROID ASSOCIATION
Jun 2016
– Aug 2018
Investigation of the Human Glioblastoma Ciliome
Role: Principal Investigator
Funding: AMER BRAIN TUMOR ASSOCIATION
May 2015
– May 2016
Influence of neonatal seizure on neuronal ciliogenesis
Role: Principal Investigator
Funding: EPILEPSY FOU OF AMERICA
Apr 2015
– Mar 2018
Cortical Circuit Formation and Plasticity Following Neonatal Brain Injury
Role: Project Manager
Funding: NATL INST OF HLTH NINDS
Jul 2013
– Jun 2021
Florida Center for Brain Tumor Research – Statewide Brain Tumor Registry Program at the McKnight Brain Institute
Role: Project Manager
Funding: FL DEPT OF HLTH
Jan 2013
– Dec 2017
Identifying and Targeting Therapy Resistant Cells in Glioblastoma
Role: Principal Investigator
Funding: AMER CANCER SOC
Apr 2008
ACTIVE
Evelyn F. McKnight Brain Research Program in Age-Related Memory Loss.
Role: Project Manager
Funding: MCKNIGHT FOU
Contact Details
Phones:
- Business:
- (352) 273-5534
Emails:
- Business:
- msarkisian@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100244
GAINESVILLE FL 32610