Matthew R Sarkisian

Matthew R Sarkisian,

Associate Professor, Program Director MS In Neuroscience Graduate Program

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 273-5534
Business Email: msarkisian@ufl.edu

Publications

2021
HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells.
Cancers. 13(7) [DOI] 10.3390/cancers13071644. [PMID] 33915983.
2020
CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas.
Proceedings of the National Academy of Sciences of the United States of America. 117(2):1129-1138 [DOI] 10.1073/pnas.1910856117. [PMID] 31879345.
2019
Emerging Roles of Primary Cilia in Glioma.
Frontiers in cellular neuroscience. 13 [DOI] 10.3389/fncel.2019.00055. [PMID] 30842728.
2019
In utero electroporation-based translating ribosome affinity purification identifies age-dependent mRNA expression in cortical pyramidal neurons.
Neuroscience research. 143:44-52 [DOI] 10.1016/j.neures.2018.05.006. [PMID] 29857015.
2018
Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles.
Cilia. 7 [DOI] 10.1186/s13630-018-0060-5. [PMID] 30410731.
2018
Infiltrative and drug-resistant slow-cycling cells support metabolic heterogeneity in glioblastoma.
The EMBO journal. 37(23) [DOI] 10.15252/embj.201798772. [PMID] 30322894.
2018
Personalized Tumor RNA Loaded Lipid-Nanoparticles Prime the Systemic and Intratumoral Milieu for Response to Cancer Immunotherapy.
Nano letters. 18(10):6195-6206 [DOI] 10.1021/acs.nanolett.8b02179. [PMID] 30259750.
2016
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
Oncotarget. 7(6):7029-43 [DOI] 10.18632/oncotarget.6854. [PMID] 26760767.
2016
Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons.
Experimental neurology. 282:119-27 [DOI] 10.1016/j.expneurol.2016.05.015. [PMID] 27181411.
2016
Neuroanatomical characterization of the cellular and axonal architecture of subcortical band heterotopia in the BXD29-Tlr4lps-2J/J mouse cortex.
Neuroscience. 337:48-65 [DOI] 10.1016/j.neuroscience.2016.08.049. [PMID] 27595889.
2016
PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide.
Translational oncology. 9(5):392-402 [DOI] 10.1016/j.tranon.2016.08.006. [PMID] 27661404.
2016
Type 3 Adenylyl Cyclase and Somatostatin Receptor 3 Expression Persists in Aged Rat Neocortical and Hippocampal Neuronal Cilia.
Frontiers in aging neuroscience. 8 [DOI] 10.3389/fnagi.2016.00127. [PMID] 27303293.
2015
Influences of primary cilia on cortical morphogenesis and neuronal subtype maturation.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 21(2):136-51 [DOI] 10.1177/1073858414531074. [PMID] 24740576.
2014
Detection of primary cilia in human glioblastoma.
Journal of neuro-oncology. 117(1):15-24 [DOI] 10.1007/s11060-013-1340-y. [PMID] 24510433.
2013
Arborization of dendrites by developing neocortical neurons is dependent on primary cilia and type 3 adenylyl cyclase.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(6):2626-38 [DOI] 10.1523/JNEUROSCI.2906-12.2013. [PMID] 23392690.
2013
The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance.
EMBO molecular medicine. 5(8):1196-212 [DOI] 10.1002/emmm.201302827. [PMID] 23818228.
2012
Abnormal levels of Gadd45alpha in developing neocortex impair neurite outgrowth.
PloS one. 7(9) [DOI] 10.1371/journal.pone.0044207. [PMID] 22970179.
2012
Development and distribution of neuronal cilia in mouse neocortex.
The Journal of comparative neurology. 520(4):848-73 [DOI] 10.1002/cne.22793. [PMID] 22020803.
2012
Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction.
Acta neuropathologica. 123(6):807-23 [DOI] 10.1007/s00401-012-0979-3. [PMID] 22539017.
2011
Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin.
Neuroscience. 190:398-408 [DOI] 10.1016/j.neuroscience.2011.06.010. [PMID] 21689730.
2011
Failed cytokinesis of neural progenitors in citron kinase-deficient rats leads to multiciliated neurons.
Cerebral cortex (New York, N.Y. : 1991). 21(2):338-44 [DOI] 10.1093/cercor/bhq099. [PMID] 20525772.
2010
Discs large 5: a new regulator of Citron kinase localization in developing neocortex: comment on: Chang Y, et al. Cell Cycle 2010; 9:1990-7.
Cell cycle (Georgetown, Tex.). 9(10) [PMID] 20505324.
View on: PubMed
2008
Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex.
Neuron. 60(2):273-84 [DOI] 10.1016/j.neuron.2008.09.026. [PMID] 18957219.
2008
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling.
Proceedings of the National Academy of Sciences of the United States of America. 105(35):13127-32 [DOI] 10.1073/pnas.0804558105. [PMID] 18728187.
2008
The stumpy gene is required for mammalian ciliogenesis.
Proceedings of the National Academy of Sciences of the United States of America. 105(8):2853-8 [DOI] 10.1073/pnas.0712385105. [PMID] 18287022.
2008
Trouble making the first move: interpreting arrested neuronal migration in the cerebral cortex.
Trends in neurosciences. 31(2):54-61 [DOI] 10.1016/j.tins.2007.11.009. [PMID] 18201775.
2007
Citron kinase is required for postnatal neurogenesis in the hippocampus.
Developmental neuroscience. 29(1-2):113-23 [PMID] 17148954.
View on: PubMed
2007
Genetic determinants of neuronal migration in the cerebral cortex.
Novartis Foundation symposium. 288:45-53; discussion 53 [PMID] 18494251.
View on: PubMed
2006
MEKK4 signaling regulates filamin expression and neuronal migration.
Neuron. 52(5):789-801 [PMID] 17145501.
View on: PubMed
2005
Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.
Proceedings of the National Academy of Sciences of the United States of America. 102(10):3846-51 [PMID] 15731347.
View on: PubMed
2003
Phosphatidylserine receptor is required for clearance of apoptotic cells.
Science (New York, N.Y.). 302(5650):1560-3 [PMID] 14645847.
View on: PubMed
2002
Citron-kinase, a protein essential to cytokinesis in neuronal progenitors, is deleted in the flathead mutant rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(8) [PMID] 11932363.
View on: PubMed
2002
Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus.
Epilepsy research. 48(1-2):3-13 [PMID] 11823105.
View on: PubMed
2001
Altered interneuron development in the cerebral cortex of the flathead mutant.
Cerebral cortex (New York, N.Y. : 1991). 11(8):734-43 [PMID] 11459763.
View on: PubMed
2001
Animal Models for Human Seizure and Epileptic Activity. Reply.
Epilepsy & behavior : E&B. 2(5):506-507 [PMID] 12609298.
View on: PubMed
2001
Enhanced auditory reversal learning by genetic activation of protein kinase C in small groups of rat hippocampal neurons.
Brain research. Molecular brain research. 93(2):127-36 [PMID] 11589990.
View on: PubMed
2001
Overview of the Current Animal Models for Human Seizure and Epileptic Disorders.
Epilepsy & behavior : E&B. 2(3):201-216 [PMID] 12609365.
View on: PubMed
2000
Protective effects of prenatal choline supplementation on seizure-induced memory impairment.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(22) [PMID] 11069978.
View on: PubMed
1999
Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development.
Epilepsia. 40(4):394-400 [PMID] 10219263.
View on: PubMed
1999
Consequences of cortical dysplasia during development in rats.
Epilepsia. 40(5):537-44 [PMID] 10386521.
View on: PubMed
1999
Consequences of recurrent seizures during early brain development.
Neuroscience. 92(4):1443-54 [PMID] 10426498.
View on: PubMed
1999
Effects of hyperthermia and continuous hippocampal stimulation on the immature and adult brain.
Brain & development. 21(5):318-25 [PMID] 10413019.
View on: PubMed
1999
Mossy fiber sprouting after recurrent seizures during early development in rats.
The Journal of comparative neurology. 404(4):537-53 [PMID] 9987996.
View on: PubMed
1998
A gene essential to brain growth and development maps to the distal arm of rat chromosome 12.
Neuroscience letters. 251(1):5-8 [PMID] 9714451.
View on: PubMed
1998
Comparison of valproate and phenobarbital treatment after status epilepticus in rats.
Neurology. 51(1):41-8 [PMID] 9674776.
View on: PubMed
1998
Synaptic reorganization following kainic acid-induced seizures during development.
Brain research. Developmental brain research. 107(2):169-77 [PMID] 9593878.
View on: PubMed
1997
[Consequences of recurrent seizures during development].
Revista de neurologia. 25(141):749-53 [PMID] 9206603.
View on: PubMed
1997
Multiple kainic acid seizures in the immature and adult brain: ictal manifestations and long-term effects on learning and memory.
Epilepsia. 38(11):1157-66 [PMID] 9579915.
View on: PubMed
1997
Seizure-induced glutamate release in mature and immature animals: an in vivo microdialysis study.
Neuroreport. 8(8):2019-23 [PMID] 9223095.
View on: PubMed
1996
Age-dependent effects of glutamate toxicity in the hippocampus.
Brain research. Developmental brain research. 97(2):178-84 [PMID] 8997502.
View on: PubMed
1996
Long-term effects of excitatory amino acid antagonists NBQX and MK-801 on the developing brain.
Brain research. Developmental brain research. 95(2):256-62 [PMID] 8874901.
View on: PubMed
1996
Recurrent seizures in immature rats: effect on auditory and visual discrimination.
Brain research. Developmental brain research. 95(2):283-92 [PMID] 8874904.
View on: PubMed

Grants

Jul 2019 – Dec 2021
Enhancing TTFields Therapy for Glioblastoma By Dual Inhibition of HDAC6 and SIRT2
Role: Principal Investigator
Funding: AMER ASSO FOR CANCER RESEARCH
Sep 2018 ACTIVE
Targeting CCR2-expressing myeloid cells to overcome immune checkpoint inhibitor resistance in glioma
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Jun 2018 – Dec 2020
Primary Cilia-Derived ARL13B As a Biomarker and Promoter of?Gliomagenesis
Role: Principal Investigator
Funding: AMER BRAIN TUMOR ASSOCIATION
Jul 2017 – Feb 2019
Effects of Early Hypo- and Hyperthyroidism on Long-term Cortical Circuit Plasticity
Role: Co-Investigator
Funding: AMERICAN THYROID ASSOCIATION
Jun 2016 – Aug 2018
Investigation of the Human Glioblastoma Ciliome
Role: Principal Investigator
Funding: AMER BRAIN TUMOR ASSOCIATION
May 2015 – May 2016
Influence of neonatal seizure on neuronal ciliogenesis
Role: Principal Investigator
Funding: EPILEPSY FOU OF AMERICA
Apr 2015 – Mar 2018
Cortical Circuit Formation and Plasticity Following Neonatal Brain Injury
Role: Project Manager
Funding: NATL INST OF HLTH NINDS
Jul 2013 – Jun 2021
Florida Center for Brain Tumor Research – Statewide Brain Tumor Registry Program at the McKnight Brain Institute
Role: Project Manager
Funding: FL DEPT OF HLTH
Jan 2013 – Dec 2017
Identifying and Targeting Therapy Resistant Cells in Glioblastoma
Role: Principal Investigator
Funding: AMER CANCER SOC
Apr 2008 ACTIVE
Evelyn F. McKnight Brain Research Program in Age-Related Memory Loss.
Role: Project Manager
Funding: MCKNIGHT FOU

Teaching Profile

Courses Taught
2011-2022
GMS6021 Organization and Development of the Nervous System
2017-2021
GMS6705 Functional Human Neuroanatomy
2019,2021
GMS6013 Developmental Genetics
2018
GMS7980 Research for Doctoral Dissertation
2015
GMS7794 Neuroscience Seminar
2011,2021-2022
GMS6073 Disorders of the Developing Nervous System
2010
GMS7795 Special Topics in Neuroscience
2022
GMS6007 Fundamentals of Neuroscience
2021-2022
GMS6029 Brain Journal Club

Contact Details

Phones:
Business:
(352) 273-5534
Emails:
Business:
msarkisian@ufl.edu