Yong Ran,
Research Assistant Professor
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-9748-4392
Publications
2020
CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells.
Frontiers in immunology.
11
[DOI] 10.3389/fimmu.2020.00735.
[PMID] 32457739.
2020
γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not
Alzheimer's Research & Therapy.
12(1)
[DOI] 10.1186/s13195-020-00622-5.
[PMID] 32430033.
2019
An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes
Journal of Experimental Medicine.
216(11):2479-2491
[DOI] 10.1084/jem.20190430.
[PMID] 31467037.
2019
Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells
Journal of Biological Chemistry.
294(29):11276-11285
[DOI] 10.1074/jbc.ra119.008041.
2019
Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells
Journal of Biological Chemistry.
294(29):11276-11285
[DOI] 10.1074/jbc.ra119.008041.
2018
High‐affinity interactions and signal transduction between Aβ oligomers and
TREM
2
EMBO Molecular Medicine.
10(11)
[DOI] 10.15252/emmm.201809027.
[PMID] 30341064.
2018
Novel monoclonal antibodies targeting the microtubule-binding domain of human tau.
PloS one.
13(4)
[DOI] 10.1371/journal.pone.0195211.
[PMID] 29608591.
2018
Short Aβ peptides attenuate Aβ42 toxicity in vivo
Journal of Experimental Medicine.
215(1):283-301
[DOI] 10.1084/jem.20170600.
[PMID] 29208777.
2017
A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies.
PloS one.
12(9)
[DOI] 10.1371/journal.pone.0184731.
[PMID] 28910367.
2017
γ‐Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct
EMBO Molecular Medicine.
9(7):950-966
[DOI] 10.15252/emmm.201607265.
[PMID] 28539479.
2015
Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator.
Molecular neurodegeneration.
10
[DOI] 10.1186/s13024-015-0021-z.
[PMID] 26169917.
2015
Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors.
PloS one.
10(6)
[DOI] 10.1371/journal.pone.0128619.
[PMID] 26046535.
2015
Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits.
Acta neuropathologica communications.
3
[DOI] 10.1186/s40478-015-0252-9.
[PMID] 26566997.
2015
The stress response neuropeptide CRF increases amyloid-β production by regulating γ-secretase activity.
The EMBO journal.
34(12):1674-86
[DOI] 10.15252/embj.201488795.
[PMID] 25964433.
2014
Characterizing solution surface loop conformational flexibility of the GM2 activator protein.
The journal of physical chemistry. B.
118(36):10607-17
[DOI] 10.1021/jp505938t.
[PMID] 25127419.
2014
Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators.
Biochemistry.
53(12):1947-57
[DOI] 10.1021/bi401521t.
[PMID] 24620716.
2014
Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity.
PloS one.
9(10)
[DOI] 10.1371/journal.pone.0111553.
[PMID] 25350374.
2014
γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.
The Journal of biological chemistry.
289(6):3276-87
[DOI] 10.1074/jbc.M113.512921.
[PMID] 24352661.
2013
Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein.
Acta neuropathologica communications.
1
[DOI] 10.1186/2051-5960-1-38.
[PMID] 24252149.
2012
Shifting a complex debate on γ-secretase cleavage and Alzheimer’s disease.
The EMBO journal.
31(10):2237-9
[DOI] 10.1038/emboj.2012.111.
[PMID] 22505028.
2009
Interactions of the GM2 activator protein with phosphatidylcholine bilayers: a site-directed spin-labeling power saturation study.
Biophysical journal.
97(5):1436-44
[DOI] 10.1016/j.bpj.2009.05.058.
[PMID] 19720032.
2009
Ligand extraction properties of the GM2 activator protein and its interactions with lipid vesicles.
Biophysical journal.
97(1):257-66
[DOI] 10.1016/j.bpj.2009.03.065.
[PMID] 19580763.
2008
A dansyl fluorescence-based assay for monitoring kinetics of lipid extraction and transfer.
Analytical biochemistry.
382(2):132-4
[DOI] 10.1016/j.ab.2008.07.022.
[PMID] 18694718.
2008
Anyl 105-Fluorescence Resonance Energy Transfer (Fret) Studies of the Effects of Popc Vesicle Size On Gm2-Activator Protein Binding
.
235
2008
Biol 21-Characterization of the Interactions of the Gm2 Activator Protein With Bilayer Membrane Surfaces
.
235
2008
Biol 230-Membrane Binding and Dissociation Kinetics of Gm2 Activator Protein
.
235
2008
StAR-like activity and molten globule behavior of StARD6, a male germ-line protein.
Biochemistry.
47(8):2277-88
[DOI] 10.1021/bi701966a.
[PMID] 18211099.
High affinity interactions and signal transduction between Aβ oligomers and TREM2
.
[DOI] 10.1101/269787.
Grants
Jul 2021
ACTIVE
A consortium effort to translate therapies for neurological diseases via an immune-competent organotypic platform
Role: Co-Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL
via NATL INST OF HLTH NCATS
May 2021
ACTIVE
Function of Chimeric Phagocytic Receptor Targeting A? and Tau Protein
Role: Principal Investigator
Funding: FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Contact Details
Phones:
- Business:
- (352) 273-9690
Emails:
- Business:
- yran@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100159
GAINESVILLE FL 32610 - Business Street:
-
1275 CENTER DR J486
GAINESVILLE FL 32610