Maryam Rahman

Maryam Rahman, M.D., M.S.

Associate Professor

Department: MD-NEUROLOGICAL SURGERY
Business Phone: (352) 273-9000

About Maryam Rahman

Maryam Rahman, MD, MS, is an associate professor in the department of neurosurgery at the University of Florida. Working within the Preston A. Wells Jr. Center for Brain Tumor Therapy at UF, she specializes in the treatment of patients with brain or spinal tumors. Her focus is on novel treatment techniques, including laser interstitial thermotherapy, fluorescence-guided surgery, immunotherapy/vaccine therapy and awake cortical mapping during surgery.

Dr. Rahman received a bachelor’s degree in chemistry from the Johns Hopkins University, and attended medical school and completed a neurosurgical residency at UF. During her training, she completed a two-year neuro­oncology fellowship under the direction of world-renowned scientist Brent Reynolds, PhD, studying tumor stem cells and their role in developing novel therapy for brain tumors. At the same time, she earned her Master of Science degree in clinical investigation. After residency, Dr. Rahman completed a surgical neuro-oncology fellowship at Johns Hopkins. During her training, she was granted the Chuck Shank Award for Excellence in Neurosurgery, the Resident Research Award, the Resident High Board Score Award and the Outstanding Resident Educator Award. She currently serves on the executive committee of the Congress of Neurological Surgeons. She served as 2018-2019 president of the Florida Neurological Society.

Dr. Rahman’s current interests include providing leading-edge, quality care for patients with brain tumors, teaching and mentoring medical students and residents and performing translational research to discover and implement novel therapies for malignant brain tumors. As a member of the Preston A. Wells Jr. Center for Brain Tumor Therapy at UF, she works with expert neuro-oncologists, radiation oncologists and researchers to provide progressive treatment options for patients. Dr. Rahman performs awake cortical mapping, fluorescence-guided surgery and laser interstitial therapy for the treatment of brain tumors.

In addition to her busy clinical practice, she mentors doctors in training. She was awarded the 2016 Basic Science Teacher of the Year through the College of Medicine, and in 2018 and 2019, she received the Exemplary Teacher Award.

Dr. Rahman is dedicated to finding a cure for brain tumors. Her laboratory focuses on identifying novel immunotherapy approaches to overcome resistance in patients with brain cancer. She collaborates with Dr. Duane Mitchell and many other investigators in the UF Brain Tumor lmmunotherapy Program. Her training in neurosurgical oncology and tumor stem cell biology has provided her the foundation to investigate several novel immunotherapy strategies for patients with brain cancer.

Dr. Rahman’s work is supported by grants from the NIH, the Preston A. Wells Jr. endowment and private foundations. Her translational research is actively being tested in human clinical trials. She has published more than 60 peer-reviewed articles, multiple book chapters and has been invited to speak at various national conferences and events.

Teaching Profile

Courses Taught
2018
BMS6020 Clinical Neuroscience
2018
MDT7801 Elect Top/Neuroscienc
2018
MDC7600 Surgery Clerkship
2018
MDT7650 Elect Top/Neurol Surg
2018
MDT7090 Elective Topics

Clinical Profile

Specialties
  • Neurosurgery
Areas of Interest
  • Acoustic neuroma
  • Brain surgery
  • Brain tumor – primary – adults
  • Encephalocele / CSF leak
  • Meningioma
  • Spinal tumor

Publications

2022
Contemporary RNA Therapeutics for Glioblastoma.
Neuromolecular medicine. 24(1):8-12 [DOI] 10.1007/s12017-021-08669-9. [PMID] 34101090.
2022
Glioma Immunotherapy: Advances and Challenges for Spinal Cord Gliomas.
Neurospine. 19(1):13-29 [DOI] 10.14245/ns.2143210.605. [PMID] 35130421.
2022
Introduction. Immunology of neurosurgical diseases.
Neurosurgical focus. 52(2) [DOI] 10.3171/2021.12.FOCUS21730. [PMID] 35104789.
2021
A modeling approach to derive baseline risk estimates for GRADE recommendations: Concepts, development, and results of its application to the American Society of Hematology 2019 guidelines on prevention of venous thromboembolism in surgical hospitalized patients.
Journal of clinical epidemiology. 140:69-78 [DOI] 10.1016/j.jclinepi.2021.07.010. [PMID] 34284102.
2021
A review of glioblastoma immunotherapy.
Journal of neuro-oncology. 151(1):41-53 [DOI] 10.1007/s11060-020-03448-1. [PMID] 32253714.
2021
Glioblastoma with a primitive neuroectodermal component: two cases with implications for glioblastoma cell-of-origin.
Clinical imaging. 73:139-145 [DOI] 10.1016/j.clinimag.2020.10.041. [PMID] 33406475.
2021
In Reply to the to Letter to the Editor Regarding “Academic Accomplishments of Female Neurosurgeons Currently in Practice in the United States”.
World neurosurgery. 154 [DOI] 10.1016/j.wneu.2021.07.040. [PMID] 34583491.
2021
Metabolomics Monitoring of Treatment Response to Brain Tumor Immunotherapy.
Frontiers in oncology. 11 [DOI] 10.3389/fonc.2021.691246. [PMID] 34150663.
2021
Optimizing T Cell-Based Therapy for Glioblastoma.
Frontiers in immunology. 12 [DOI] 10.3389/fimmu.2021.705580. [PMID] 34421912.
2021
Role of Laser Interstitial Thermal Therapy in the Management of Primary and Metastatic Brain Tumors.
Current treatment options in oncology. 22(12) [DOI] 10.1007/s11864-021-00912-6. [PMID] 34687357.
2020
Adult immuno-oncology: using past failures to inform the future.
Neuro-oncology. 22(9):1249-1261 [DOI] 10.1093/neuonc/noaa116. [PMID] 32391559.
2020
Comparing Standard Performance and Outcome Measures in Hospitalized Pituitary Tumor Patients with Secretory versus Nonsecretory Tumors.
World neurosurgery. 135:e510-e519 [DOI] 10.1016/j.wneu.2019.12.059. [PMID] 31863896.
2020
Epidemiology of Brain Metastases.
Neurosurgery clinics of North America. 31(4):481-488 [DOI] 10.1016/j.nec.2020.06.001. [PMID] 32921345.
2020
Impact of Extent of Resection on Incidence of Postoperative Complications in Patients With Glioblastoma.
Neurosurgery. 86(5):625-630 [DOI] 10.1093/neuros/nyz313. [PMID] 31342060.
2020
Pharmacologic thromboprophylaxis in adult patients undergoing neurosurgical interventions for preventing venous thromboembolism.
Blood advances. 4(12):2798-2809 [DOI] 10.1182/bloodadvances.2020002195. [PMID] 32574367.
2020
Virtual education in neurosurgery during the COVID-19 pandemic
Neurosurgical Focus. 49(6) [DOI] 10.3171/2020.9.FOCUS20672.
2019
American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients.
Blood advances. 3(23):3898-3944 [DOI] 10.1182/bloodadvances.2019000975. [PMID] 31794602.
2019
CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors.
Nature communications. 10(1) [DOI] 10.1038/s41467-019-11869-4. [PMID] 31488817.
2019
Modulation of temozolomide dose differentially affects T-cell response to immune checkpoint inhibition.
Neuro-oncology. 21(6):730-741 [DOI] 10.1093/neuonc/noz015. [PMID] 30668768.
2019
Reimbursement patterns for neurosurgery: Analysis of the NERVES survey results from 2011-2016.
Clinical neurology and neurosurgery. 184 [DOI] 10.1016/j.clineuro.2019.105406. [PMID] 31302381.
2019
The role of CMV in glioblastoma and implications for immunotherapeutic strategies.
Oncoimmunology. 8(1) [DOI] 10.1080/2162402X.2018.1514921. [PMID] 30546954.
2018
Analysis of immunobiologic markers in primary and recurrent glioblastoma.
Journal of neuro-oncology. 137(2):249-257 [DOI] 10.1007/s11060-017-2732-1. [PMID] 29302887.
2018
Personalized Tumor RNA Loaded Lipid-Nanoparticles Prime the Systemic and Intratumoral Milieu for Response to Cancer Immunotherapy.
Nano letters. 18(10):6195-6206 [DOI] 10.1021/acs.nanolett.8b02179. [PMID] 30259750.
2018
Techniques to Ensure Accurate Targeting for Delivery of Awake Laser Interstitial Thermotherapy.
Operative neurosurgery (Hagerstown, Md.). 15(4):454-460 [DOI] 10.1093/ons/opx290. [PMID] 29444286.
2018
Temozolomide for immunomodulation in the treatment of glioblastoma.
Neuro-oncology. 20(12):1566-1572 [DOI] 10.1093/neuonc/noy072. [PMID] 29733389.
2017
A Contemporary Framework of Language Processing in the Human Brain in the Context of Preoperative and Intraoperative Language Mapping
Neuroradiology. 59(1):69-87 [DOI] 10.1007/s00234-016-1772-0.
2017
Prophylactic Antiepileptic Drug Use in Patients With Brain Tumors Undergoing Craniotomy
World Neurosurgery. 98:28-33 [DOI] 10.1016/j.wneu.2016.10.079.
2017
The Effects of New or Worsened Postoperative Neurological Deficits on Survival of Patients With Glioblastoma
Journal of Neurosurgery. 127(1):123-131 [DOI] 10.3171/2016.7.JNS16396.
2016
Do Tumor and Ventricular Volume Predict the Need for Postresection Shunting in Colloid Cyst Patients?
Journal of Neurosurgery. 125(3):585-590 [DOI] 10.3171/2015.9.JNS151183.
2016
Variant Neurogenic Stunned Myocardium in a Young Female After Subarachnoid Hemorrhage
A&A practice. 6(1):10-13 [DOI] 10.1213/XAA.0000000000000172. [PMID] 26422453.
2015
Effects of Perioperative Acetyl Salicylic Acid on Clinical Outcomes in Patients Undergoing Craniotomy for Brain Tumor.
World neurosurgery. 84(1):41-7 [DOI] 10.1016/j.wneu.2015.02.016. [PMID] 25727304.
2015
Health disparities and stroke: the influence of insurance status on the prevalence of patient safety indicators and hospital-acquired conditions.
Journal of neurosurgery. 122(4):870-5 [DOI] 10.3171/2014.12.JNS14646. [PMID] 25658779.
2015
Insurance status influences the rates of reportable quality metrics in brain tumor patients: a nationwide inpatient sample study.
Neurosurgery. 76(3):239-47; discussion 247 [DOI] 10.1227/NEU.0000000000000594. [PMID] 25603104.
2014
The risk of malignancy anywhere in the body after linear accelerator (LINAC) stereotactic radiosurgery.
Stereotactic and functional neurosurgery. 92(5):323-33 [DOI] 10.1159/000365225. [PMID] 25277349.
2013
Controlling tumor invasion: bevacizumab and BMP4 for glioblastoma.
Future oncology (London, England). 9(9):1389-96 [DOI] 10.2217/fon.13.96. [PMID] 23980685.
2013
Establishing standard performance measures for adult brain tumor patients: a Nationwide Inpatient Sample database study.
Neuro-oncology. 15(11):1580-8 [DOI] 10.1093/neuonc/not108. [PMID] 24084409.
2013
Establishing standard performance measures for adult stroke patients: a nationwide inpatient sample database study.
World neurosurgery. 80(6):699-708.e2 [DOI] 10.1016/j.wneu.2013.08.024. [PMID] 23994132.
2013
Prevalence of patient safety indicators and hospital-acquired conditions in those treated for unruptured cerebral aneurysms: establishing standard performance measures using the Nationwide Inpatient Sample database.
Journal of neurosurgery. 119(4):966-73 [DOI] 10.3171/2013.5.JNS122378. [PMID] 23746098.
2013
The prevalence of patient safety indicators and hospital-acquired conditions in patients with ruptured cerebral aneurysms: establishing standard performance measures using the Nationwide Inpatient Sample database.
Journal of neurosurgery. 119(6):1633-40 [DOI] 10.3171/2013.7.JNS13595. [PMID] 23991899.
2012
Radiographic response of brain metastasis after linear accelerator radiosurgery.
Stereotactic and functional neurosurgery. 90(2):69-78 [DOI] 10.1159/000334669. [PMID] 22286386.
2012
The future of glioma treatment: stem cells, nanotechnology and personalized medicine.
Future oncology (London, England). 8(9):1149-56 [DOI] 10.2217/fon.12.111. [PMID] 23030489.
2011
Atypical Rasmussen’s encephalitis treated with temporal lobectomy.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 18(2):287-90 [DOI] 10.1016/j.jocn.2010.05.011. [PMID] 21163652.
2011
DBS candidates that fall short on a levodopa challenge test: alternative and important indications.
The neurologist. 17(5):263-8 [DOI] 10.1097/NRL.0b013e31822d1069. [PMID] 21881468.
2011
Ethynyldeoxyuridine (EdU) suppresses in vitro population expansion and in vivo tumor progression of human glioblastoma cells.
Journal of neuro-oncology. 105(3):485-98 [DOI] 10.1007/s11060-011-0621-6. [PMID] 21643840.
2011
Evidence for label-retaining tumour-initiating cells in human glioblastoma.
Brain : a journal of neurology. 134(Pt 5):1331-43 [DOI] 10.1093/brain/awr081. [PMID] 21515906.
2011
Investigational therapies for brain metastases.
Neurosurgery clinics of North America. 22(1):87-96, vii [DOI] 10.1016/j.nec.2010.08.008. [PMID] 21109153.
2011
Midterm Clinical and Angiographic Follow Up for the First Fda-Approved Prospective, Single-Arm Trial of Primary Stenting for Stroke: Saris (Stent-Assisted Recanalization for Acute Ischemic Stroke)
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2011
Midterm clinical and angiographic follow-up for the first Food and Drug Administration-approved prospective, Single-Arm Trial of Primary Stenting for Stroke: SARIS (Stent-Assisted Recanalization for Acute Ischemic Stroke).
Neurosurgery. 69(4):915-20; discussion 920 [DOI] 10.1227/NEU.0b013e318222afd1. [PMID] 21552168.
2011
Purification of immature neuronal cells from neural stem cell progeny.
PloS one. 6(6) [DOI] 10.1371/journal.pone.0020941. [PMID] 21687800.
2011
Recanalization therapy for acute ischemic stroke, part 1: surgical embolectomy and chemical thrombolysis.
Neurosurgical review. 34(1):1-9 [DOI] 10.1007/s10143-010-0293-2. [PMID] 21107631.
2011
Recanalization therapy for acute ischemic stroke, part 2: mechanical intra-arterial technologies.
Neurosurgical review. 34(1):11-20 [DOI] 10.1007/s10143-010-0294-1. [PMID] 21107630.
2011
Spontaneous intracranial hypotension: dilemmas in diagnosis.
Neurosurgery. 69(1):4-14; discussion 14 [DOI] 10.1227/NEU.0b013e3182134399. [PMID] 21368701.
2011
The cancer stem cell hypothesis: failures and pitfalls.
Neurosurgery. 68(2):531-45; discussion 545 [DOI] 10.1227/NEU.0b013e3181ff9eb5. [PMID] 21135745.
2011
Unruptured cerebral aneurysms do not shrink when they rupture: multicenter collaborative aneurysm study group.
Neurosurgery. 68(1):155-60; discussion 160 [DOI] 10.1227/NEU.0b013e3181ff357c. [PMID] 21150760.
2010
Circulating Tumor Cells (Ctcs) in Patients With Glioblastoma Multiforme (Gbm)
Neuro-Oncology. 12
2010
Disrupting abnormal electrical activity with deep brain stimulation: is epilepsy the next frontier?
Neurosurgical focus. 29(2) [DOI] 10.3171/2010.4.FOCUS10104. [PMID] 20672924.
2010
Size ratio correlates with intracranial aneurysm rupture status: a prospective study.
Stroke. 41(5):916-20 [DOI] 10.1161/STROKEAHA.109.574244. [PMID] 20378866.
2009
Aggressive surgical management of patients with Chiari II malformation and brainstem dysfunction.
Pediatric neurosurgery. 45(5):337-44 [DOI] 10.1159/000257521. [PMID] 19907196.
2009
Anatomic study of the infraorbital foramen for radiofrequency neurotomy of the infraorbital nerve.
Neurosurgery. 64(5 Suppl 2):423-7; discussion 427 [DOI] 10.1227/01.NEU.0000336327.10368.79. [PMID] 19404120.
2009
Direct thrombolysis for cerebral venous sinus thrombosis.
Neurosurgical focus. 27(5) [DOI] 10.3171/2009.7.FOCUS09146. [PMID] 19877797.
2009
Early history of the stereotactic apparatus in neurosurgery.
Neurosurgical focus. 27(3) [DOI] 10.3171/2009.7.FOCUS09118. [PMID] 19722814.
2009
Hyponatremia in neurosurgical patients: clinical guidelines development.
Neurosurgery. 65(5):925-35; discussion 935 [DOI] 10.1227/01.NEU.0000358954.62182.B3. [PMID] 19834406.
2009
Stereotactic radiosurgery and the linear accelerator: accelerating electrons in neurosurgery.
Neurosurgical focus. 27(3) [DOI] 10.3171/2009.7.FOCUS09116. [PMID] 19722815.
2008
Comparison of techniques for decompressive lumbar laminectomy: the minimally invasive versus the “classic” open approach.
Minimally invasive neurosurgery : MIN. 51(2):100-5 [DOI] 10.1055/s-2007-1022542. [PMID] 18401823.

Grants

Jun 2022 ACTIVE
Role of Natural Killer Cells in Efficacy of a Novel Glioblastoma mRNA Vaccine
Role: Principal Investigator
Funding: AMER BRAIN TUMOR ASSOCIATION
Jun 2021 – Aug 2021
The Immune Effects of a Novel Vaccine in Combination with Standard of Care
Role: Principal Investigator
Funding: AMER BRAIN TUMOR ASSOCIATION
Feb 2021 ACTIVE
Overcoming the blood-brain barrier with nanoparticle vaccines against gliomas
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Jul 2020 ACTIVE
Hydrogel vaccine immunotherapy against brain tumor
Role: Principal Investigator
Funding: UF FOUNDATION
Jul 2020 ACTIVE
In situ modulation of DC vaccine to improve the immunotherapy efficacy against brain tumor by biocompatible Polyacrylamide-PEG hydrogel
Role: Principal Investigator
Funding: UF FOUNDATION
Dec 2019 – Aug 2021
A vaccine strategy to overcome treatment induced immunosuppression in glioma
Role: Principal Investigator
Funding: AMER BRAIN TUMOR ASSOCIATION
Sep 2019 ACTIVE
Recurrent Brain Metastasis Immune Effects and RespOnse to Laser Interstitial ThermotHerapy (LITT) and Pembrolizumab in Combination (TORCH)
Role: Principal Investigator
Funding: MONTERIS MEDICAL
Jul 2018 ACTIVE
Florida Center for Brain Tumor Research
Role: Principal Investigator
Funding: FL DEPT OF HLTH
Dec 2016 ACTIVE
Leveraging Temozolomide to Improve Treatment Efficacy of Immune Checkpoint Blockade in Glioblastoma
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2016 – Jun 2018
USING SR233 FOR ENHANCING CELLULAR MIGRATION IN DENDRITICELL VACCINE THERAPY FOR MALIGNANT BRAIN TUMORS
Role: Principal Investigator
Funding: OCALA ROYAL DAMES FOR CANCER RESEARCH
Feb 2015 ACTIVE
UF Health Cancer Center Pilot Project Grants funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jul 2013 – Jun 2021
Florida Center for Brain Tumor Research – Statewide Brain Tumor Registry Program at the McKnight Brain Institute
Role: Project Manager
Funding: FL DEPT OF HLTH

Education

Residency – Surgery
2006 · University of Florida
Medical Degree
2005 · University of Florida
Residency – Neurological Surgery
0000 · University of Florida

Contact Details

Phones:
Business:
(352) 273-9000
Addresses:
Business Mailing:
DEPT OF NEUROSURGERY
PO BOX 100265
GAINESVILLE FL 326100265
Business Street:
L2-100
Department of Neurosurgery
1149 Newell Dr.
GAINESVILLE FL 326100001