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UF Health University of Florida
Department of Neuroscience College of Medicine
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Roger L Papke

Roger L Papke, Ph.D.

Emeritus Professor

Department: MD-PHARMACOLOGY – THERAPEUTICS
Business Phone: (352) 494-9920
Business Email: rlpapke@ufl.edu
CV: View Curriculum Vitae

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About Roger L Papke

Related Links:
Lab website

Accomplishments

  1. Exemplary Teacher

    UF College of Medicine

  2. Co-recipient of R&D 100

    R&D 100 Conference

  3. Top Ten Basic Science Faculty

    UF College of Medicine

Teaching Profile

Courses Taught

Research Profile

The Papke Lab studies the physiology, pharmacology, and biophysics of neurotransmitter receptors with a special emphasis on the function of nicotinic acetylcholine receptors in the brain. These are the receptors that mediate the effects of nicotine on human behavior. The lab studies how these neuronal nicotinic acetylcholine receptors function as ligand-gated ion channels, identifying parts of the molecule that are involved with the binding of neurotransmitter and the conformational change associated with receptor activation. The lab is also characterizing the selectivity of experimental nicotinic agonists for specific receptor subtypes in the brain. With this understanding, they hope to identify the mechanisms through which nicotine-like substances may alleviate some of the learning and memory impairments in animal models of dementia. The ongoing clinical development of new experimental drugs may lead to novel therapeutics for the treatment of Alzheimer’s disease.

Areas of Interest

  • Betel Quid/Areca Nut Use & Addiction
  • Cholinergic Therapeutics for Pain
  • Nicotine Addiction
  • Smoking Cessation

Publications

Academic Articles

Grants

  1. Targeting of Alpha7 nAChR for therapeutic effects

    Role:
    Principal Investigator
    Funding:
    NATL INST OF HLTH NIGMS

  2. Evaluation of the nicotinic receptor activity of a synthetic peptide

    Role:
    Principal Investigator
    Funding:
    COLLEGE OF CHARLESTON

  3. Effects of GTS-21 on smoking behavior and neurocognitive function

    Role:
    Project Manager
    Funding:
    NATL INST OF HLTH NIDA

  4. Alpha7 and RIC-3 in the cholinergic anti-inflammatory pathway

    Role:
    Principal Investigator
    Funding:
    US ISRAEL BINATIONAL SCI FOU

  5. Electrophysiological effects of nicotinic ligands on nicotinic a7 receoptors in Xenopus oocytes

    Role:
    Principal Investigator
    Funding:
    INSTITUT DE RESERCHES INTL SERVIER

  6. Targeting of alpha7 nAChR for therapeutic effects

    Role:
    Principal Investigator
    Funding:
    NATL INST OF HLTH

  7. Targeting of alpha7 nAChR for therapeutic effects

    Role:
    Principal Investigator
    Funding:
    NATL INST OF HLTH NIGMS

Education

  1. Ph.D. in Neurobiology and Behavior

    Cornell University

  2. Masters in Physiology

    Cornell University

  3. Masters in Science

    New York University

  4. Bachelors in Biology

    New York University

  5. Bachelors in Classical Civilization

    New York University

Contact Details

Phones:
Business:
(352) 494-9920
Emails:
Business:
rlpapke@ufl.edu
Addresses:
Business Mailing:
2521 NW 63RD TER
 GAINESVILLE FL 32606
Business Street:
1200 Newell Drive
R5295 ARB
 GAINESVILLE FL 32611