Kevin Otto

Kevin Otto,

Professor

Department: EG-BIOMEDICAL ENGINEERING
Business Phone: (352) 294-2227
Business Email: kevin.otto@bme.ufl.edu

About Kevin Otto

Additional Positions:
Senior Associate Chair
2020 – Current · J. Crayton Pruitt Family Department of Biomedical Engineering

Teaching Profile

Courses Taught
2015,2020-2023
BME6936 Biomedical Engineering Seminar
2016-2021
BME4409 Quantitative Physiology
2016-2017,2020
BME4931 Special Topics in Biomedical Engineering
2016,2020
BME6938 Special Topics in Biomedical Engineering
2020
BME4361 Neural Engineering
2020
BME6360 Neural Engineering
2017-2019
BME7980 Research for Doctoral Dissertation
2016-2019
BME7979 Advanced Research
2016-2019
BME6940 Supervised Teaching
2016-2019
EGN4912 Engineering Directed Independent Research
2017-2019
BME6907 BME Project
2017-2019
BME6905 Individual Work in Biomedical Engineering
2018
BME6971 Research for Master’s Thesis
2018
EEL7980 Research for Doctoral Dissertation
2018
EEL7979 Advanced Research
2018
GMS7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation
2015
BME5500 Biomedical Instrumentation
2015
BME4503 Biomedical Instrumentation
2015
BME1008 Introduction to Biomedical Engineering
2014
GMS6029 Brain Journal Club
2014
GMS7794 Neuroscience Seminar

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-2317-6194

Publications

2022
Closed-Loop, Cervical, Epidural Stimulation Elicits Respiratory Neuroplasticity after Spinal Cord Injury in Freely Behaving Rats.
eNeuro. 9(1) [DOI] 10.1523/ENEURO.0426-21.2021. [PMID] 35058311.
2021
A multi-channel peripheral nerve stimulator with integrate-and-fire encoding.
Journal of medical engineering & technology. 45(3):187-196 [DOI] 10.1080/03091902.2021.1891311. [PMID] 33729074.
2021
Acute vagus nerve stimulation enhances reversal learning in rats.
Neurobiology of learning and memory. 184 [DOI] 10.1016/j.nlm.2021.107498. [PMID] 34332068.
2021
Communication—The Role of Ascorbic Acid Oxidation During Neural Stimulation
Journal of The Electrochemical Society. 168(8) [DOI] 10.1149/1945-7111/ac17b8.
2021
Corrigendum: Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.
Frontiers in human neuroscience. 15 [DOI] 10.3389/fnhum.2021.765150. [PMID] 34658825.
2021
Development of a magnetically aligned regenerative tissue-engineered electronic nerve interface for peripheral nerve applications.
Biomaterials. 279 [DOI] 10.1016/j.biomaterials.2021.121212. [PMID] 34717196.
2021
Electrical epidural stimulation of the cervical spinal cord: implications for spinal respiratory neuroplasticity after spinal cord injury.
Journal of neurophysiology. 126(2):607-626 [DOI] 10.1152/jn.00625.2020. [PMID] 34232771.
2021
Engineering the Multi-Enzymatic Activity of Cerium Oxide Nanoparticle Coatings for the Antioxidant Protection of Implants.
Advanced nanobiomed research. 1(8) [DOI] 10.1002/anbr.202100016. [PMID] 34485991.
2021
Layer-specific parameters of intracortical microstimulation of the somatosensory cortex
Journal of Neural Engineering. 18(5) [DOI] 10.1088/1741-2552/abedde.
2021
Partial high frequency nerve block decreases neuropathic signaling following chronic sciatic nerve constriction injury
Journal of Neural Engineering. 18(2) [DOI] 10.1088/1741-2552/abbf03.
2021
Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.
Frontiers in human neuroscience. 15 [DOI] 10.3389/fnhum.2021.644593. [PMID] 33953663.
2021
Restoration of breathing after opioid overdose and spinal cord injury using temporal interference stimulation.
Communications biology. 4(1) [DOI] 10.1038/s42003-020-01604-x. [PMID] 33495588.
2021
The Role of Electrode-Site Placement in the Long-Term Stability of Intracortical Microstimulation.
Frontiers in neuroscience. 15 [DOI] 10.3389/fnins.2021.712578. [PMID] 34566563.
2020
Designing a bioelectronic treatment for Type 1 diabetes: targeted parasympathetic modulation of insulin secretion
Bioelectronics in Medicine. 3(2):17-31 [DOI] 10.2217/bem-2020-0006. [PMID] 33169091.
2020
Development of an active high-density transverse intrafascicular micro-electrode probe
Journal of Micromechanics and Microengineering. 30(1) [DOI] 10.1088/1361-6439/ab5df2.
2020
Neuron-targeted electrical modulation.
Science (New York, N.Y.). 367(6484):1303-1304 [DOI] 10.1126/science.abb0216. [PMID] 32193309.
2020
Performance of Titanium Nitride Electrodes Used for Chronic Peripheral Nerve Stimulation
ECS Meeting Abstracts. MA2020-02(20):1576-1576 [DOI] 10.1149/ma2020-02201576mtgabs.
2020
Second Harmonic Generation Imaging of Collagen in Chronically Implantable Electrodes in Brain Tissue.
Frontiers in neuroscience. 14 [DOI] 10.3389/fnins.2020.00095. [PMID] 32733179.
2019
Cleveland neural engineering workshop 2017: strategic evaluation of neural engineering.
Bioelectronic medicine. 5 [DOI] 10.1186/s42234-019-0017-z. [PMID] 32232093.
2019
Electrochemical Evaluation of Layer-by-Layer Drug Delivery Coating for Neural Interfaces
ACS Applied Bio Materials. 2(12):5597-5607 [DOI] 10.1021/acsabm.9b00688.
2019
Neural engineering: the process, applications, and its role in the future of medicine
Journal of Neural Engineering. 16(6) [DOI] 10.1088/1741-2552/ab4869. [PMID] 31557730.
2019
Somatosensory Cortex Microstimulation: Behavioral Effects of Phase Duration and Asymmetric Waveforms.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2019:1809-1812 [DOI] 10.1109/EMBC.2019.8856579. [PMID] 31946248.
2019
Targeted Vagus Nerve Stimulation does not Disrupt Cardiac Function in the Diabetic Rat.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2019:6286-6289 [DOI] 10.1109/EMBC.2019.8857474. [PMID] 31947279.
2019
The human body at cellular resolution: the NIH Human Biomolecular Atlas Program
Nature. 574(7777):187-192 [DOI] 10.1038/s41586-019-1629-x. [PMID] 31597973.
2018
Design and assessment of stimulation parameters for a novel peripheral nerve interface.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2018:5491-5494 [DOI] 10.1109/EMBC.2018.8513582. [PMID] 30441580.
2018
Effect of Asymmetric, Charge Balanced Stimuli on Elicited Compound Neural Action Potentials.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2018:3370-3373 [DOI] 10.1109/EMBC.2018.8513057. [PMID] 30441110.
2018
Electrical Neural Stimulation and Simultaneous in Vivo Monitoring with Transparent Graphene Electrode Arrays Implanted in GCaMP6f Mice.
ACS nano. 12(1):148-157 [DOI] 10.1021/acsnano.7b04321. [PMID] 29253337.
2018
High Resolution 3D Imaging of the Human Pancreas Neuro-insular Network.
Journal of visualized experiments : JoVE. (131) [DOI] 10.3791/56859. [PMID] 29443037.
2018
In situ electrochemical polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT) for peripheral nerve interfaces.
MRS communications. 8(3):1043-1049 [DOI] 10.1557/mrc.2018.138. [PMID] 34386296.
2018
Placing Sites on the Edge of Planar Silicon Microelectrodes Enhances Chronic Recording Functionality
IEEE Transactions on Biomedical Engineering. 65(6):1245-1255 [DOI] 10.1109/tbme.2017.2715811.
2018
Placing Sites on the Edge of Planar Silicon Microelectrodes Enhances Chronic Recording Functionality
IEEE Transactions on Biomedical Engineering. 65(6):1245-1255 [DOI] 10.1109/tbme.2017.2715811.
2018
PrismPlus: a mouse line expressing distinct fluorophores in four different brain cell types.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-25208-y. [PMID] 29739975.
2018
The role of inflammation on the functionality of intracortical microelectrodes.
Journal of neural engineering. 15(6) [DOI] 10.1088/1741-2552/aae4b6. [PMID] 30260321.
2018
Tissue-Engineered Peripheral Nerve Interfaces
Advanced Functional Materials. 28(12) [DOI] 10.1002/adfm.201701713.
2017
(Invited) Quantification and Manipulation of the Microelectrode-Tissue Interface for Neural Prostheses
ECS Meeting Abstracts. MA2017-02(55):2295-2295 [DOI] 10.1149/ma2017-02/55/2295.
2017
Foreign Body Response to Intracortical Microelectrodes Is Not Altered with Dip-Coating of Polyethylene Glycol (PEG).
Frontiers in neuroscience. 11 [DOI] 10.3389/fnins.2017.00513. [PMID] 28959183.
2017
Histological evaluation of flexible neural implants; flexibility limit for reducing the tissue response?
Journal of neural engineering. 14(3) [DOI] 10.1088/1741-2552/aa68f0. [PMID] 28470152.
2016
Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies.
Frontiers in neuroscience. 10 [DOI] 10.3389/fnins.2016.00119. [PMID] 27092042.
2016
The effect of multiple thin-film coatings of protein loaded sol-gel on total multi-electrode array thickness.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2016:129-132 [DOI] 10.1109/EMBC.2016.7590657. [PMID] 28268296.
2015
A flexible platform for biofeedback-driven control and personalization of electrical nerve stimulation therapy.
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. 23(3):475-84 [DOI] 10.1109/TNSRE.2014.2351271. [PMID] 25167554.
2015
The effects of chronic intracortical microstimulation on neural tissue and fine motor behavior.
Journal of neural engineering. 12(6) [DOI] 10.1088/1741-2560/12/6/066018. [PMID] 26479701.
2014
Glial cells, but not neurons, exhibit a controllable response to a localized inflammatory microenvironment in vitro.
Frontiers in neuroengineering. 7 [DOI] 10.3389/fneng.2014.00041. [PMID] 25452724.
2014
In vivo evaluation of a μECoG array for chronic stimulation.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2014:1294-7 [DOI] 10.1109/EMBC.2014.6943835. [PMID] 25570203.
2014
Materials approaches for modulating neural tissue responses to implanted microelectrodes through mechanical and biochemical means.
Current opinion in solid state & materials science. 18(6):319-328 [PMID] 25530703.
2014
Resistive and reactive changes to the impedance of intracortical microelectrodes can be mitigated with polyethylene glycol under acute in vitro and in vivo settings.
Frontiers in neuroengineering. 7 [DOI] 10.3389/fneng.2014.00033. [PMID] 25136315.
2014
The effect of chronic intracortical microstimulation on the electrode-tissue interface.
Journal of neural engineering. 11(2) [DOI] 10.1088/1741-2560/11/2/026004. [PMID] 24503702.
2014
The effect of site placement within silicon microelectrodes on the long-term electrophysiological recordings.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2014:465-8 [DOI] 10.1109/EMBC.2014.6943629. [PMID] 25569997.
2014
When “altering brain function” becomes “mind control”.
Frontiers in systems neuroscience. 8 [DOI] 10.3389/fnsys.2014.00202. [PMID] 25352789.
2013
A hybrid PDMS-Parylene subdural multi-electrode array.
Biomedical microdevices. 15(3):437-43 [DOI] 10.1007/s10544-013-9743-2. [PMID] 23334754.
2013
Chronic intracortical microelectrode arrays induce non-uniform, depth-related tissue responses.
Journal of neural engineering. 10(2) [DOI] 10.1088/1741-2560/10/2/026007. [PMID] 23428842.
2013
Constant RMS versus constant peak modulation for the perceptual equivalence of sinusoidal amplitude modulated signals.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2013:3115-8 [DOI] 10.1109/EMBC.2013.6610200. [PMID] 24110387.
2013
Intact histological characterization of brain-implanted microdevices and surrounding tissue.
Journal of visualized experiments : JoVE. (72) [DOI] 10.3791/50126. [PMID] 23426186.
2012
Novel in vitro and in vivo neural interfaces: normal and accelerated failure assessment.
IEEE pulse. 3(1):27-9 [DOI] 10.1109/MPUL.2011.2175631. [PMID] 22344947.
2012
The depth, waveform and pulse rate for electrical microstimulation of the auditory cortex.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2012:2489-92 [DOI] 10.1109/EMBC.2012.6346469. [PMID] 23366430.
2012
Voltage biasing, cyclic voltammetry, & electrical impedance spectroscopy for neural interfaces.
Journal of visualized experiments : JoVE. (60) [DOI] 10.3791/3566. [PMID] 22395095.
2011
Asymmetric versus symmetric pulses for cortical microstimulation.
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. 19(5):468-76 [DOI] 10.1109/TNSRE.2011.2166563. [PMID] 21968793.
2011
In situ characterization of the brain-microdevice interface using device-capture histology.
Journal of neuroscience methods. 201(1):67-77 [DOI] 10.1016/j.jneumeth.2011.07.012. [PMID] 21802446.
2011
In vivo polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT) in rodent cerebral cortex.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2011:5412-5 [DOI] 10.1109/IEMBS.2011.6091338. [PMID] 22255561.
2011
Investigation of the material properties of alginate for the development of hydrogel repair of dura mater.
Journal of the mechanical behavior of biomedical materials. 4(1):16-33 [DOI] 10.1016/j.jmbbm.2010.08.006. [PMID] 21094477.
2011
Multimodal, longitudinal assessment of intracortical microstimulation.
Progress in brain research. 194:131-44 [DOI] 10.1016/B978-0-444-53815-4.00011-X. [PMID] 21867800.
2011
Rat behavioral model for high-throughput parametric studies of intracortical microstimulation.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2011:7541-4 [DOI] 10.1109/IEMBS.2011.6091859. [PMID] 22256083.
2011
Robust penetrating microelectrodes for neural interfaces realized by titanium micromachining.
Biomedical microdevices. 13(3):503-15 [DOI] 10.1007/s10544-011-9519-5. [PMID] 21360044.
2011
Simultaneous recording of rat auditory cortex and thalamus via a titanium-based, microfabricated, microelectrode device.
Journal of neural engineering. 8(4) [DOI] 10.1088/1741-2560/8/4/046007. [PMID] 21628772.
2011
Theoretical analysis of intracortical microelectrode recordings.
Journal of neural engineering. 8(4) [DOI] 10.1088/1741-2560/8/4/045006. [PMID] 21775783.
2009
Effects of adsorbed proteins, an antifouling agent and long-duration DC voltage pulses on the impedance of silicon-based neural microelectrodes.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2009:7139-42 [DOI] 10.1109/IEMBS.2009.5332456. [PMID] 19963693.
2009
Evaluation of micro-electrocorticographic electrodes for electrostimulation.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2009:5510-3 [DOI] 10.1109/IEMBS.2009.5333178. [PMID] 19964123.
2009
Poly(3,4-ethylenedioxythiophene) as a Micro-Neural Interface Material for Electrostimulation.
Frontiers in neuroengineering. 2 [DOI] 10.3389/neuro.16.007.2009. [PMID] 19543541.
2009
Thin-film silica sol-gel coatings for neural microelectrodes.
Journal of neuroscience methods. 180(1):106-10 [DOI] 10.1016/j.jneumeth.2009.02.008. [PMID] 19427536.
2009
Titanium-based multi-channel, micro-electrode array for recording neural signals.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2009:2062-5 [DOI] 10.1109/IEMBS.2009.5334429. [PMID] 19964778.
2006
Optimization of microelectrode design for cortical recording based on thermal noise considerations.
Conference proceedings : … Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2006:3361-4 [PMID] 17947023.
2006
Voltage pulses change neural interface properties and improve unit recordings with chronically implanted microelectrodes.
IEEE transactions on bio-medical engineering. 53(2):333-40 [PMID] 16485763.
2005
Cortical microstimulation in auditory cortex of rat elicits best-frequency dependent behaviors.
Journal of neural engineering. 2(2):42-51 [PMID] 15928411.
2005
Microstimulation in auditory cortex provides a substrate for detailed behaviors.
Hearing research. 210(1-2):112-7 [PMID] 16209915.
2005
Naive coadaptive cortical control.
Journal of neural engineering. 2(2):52-63 [PMID] 15928412.
2005
Repeated voltage biasing improves unit recordings by reducing resistive tissue impedances.
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. 13(2):160-5 [PMID] 16003894.
2004
Bias voltages at microelectrodes change neural interface properties in vivo.
Conference proceedings : … Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2004:4103-6 [PMID] 17271203.
2004
Co-adaptive Kalman filtering in a naïve rat cortical control task.
Conference proceedings : … Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2004:4367-70 [PMID] 17271272.
2004
In vitro and in vivo testing of a wireless multichannel stimulating telemetry microsystem.
Conference proceedings : … Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2004:4294-7 [PMID] 17271254.

Grants

Jul 2021 ACTIVE
Cervical Epidural Stimulation and Respiratory Motor Plasticity
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Jun 2021 ACTIVE
Neural mechanisms of host-microbiota interaction in hypertension: a potential for bio-electronic medicine
Role: Co-Investigator
Funding: UNIV OF TOLEDO via NATL INST OF HLTH NHLBI
May 2021 ACTIVE
Mechanisms and therapeutic potential of vagus nerve stimulation in aging and Alzheimers disease
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Apr 2019 ACTIVE
The Tissue-Engineered Electronic Nerve Interface (TEENI)
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Sep 2018 ACTIVE
A 3D Tissue Map of the Human Lymphatic System
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Aug 2018 – Jul 2021
Phrenic motoneuron activation using temporal interference
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Jun 2018 – May 2020
A novel approach to activate paralyzed muscles following cervical spinal cord injury
Role: Co-Investigator
Funding: UF RESEARCH
Jan 2017 – May 2017
MELD Mind Electromagnetic Localization Device
Role: Principal Investigator
Funding: OCEANIT LABORATORIES INCORPORATED via US DEPT OF DEFENSE DARPA
Jan 2017 – Mar 2021
Cognitive Augmentation through Neuroplasticity (CAN)
Role: Principal Investigator
Funding: US DEPT OF DEFENSE DARPA
Sep 2016 – Jun 2021
Micro-coil implants for cortical activation
Role: Principal Investigator
Funding: MASSACHUSETTS GENERAL HOSPITAL via NATL INST OF HLTH NINDS
Sep 2016 – Jul 2020
Neuromodulation-based treatment of diabetes: identifying anatomical and physiological pancreatic innervation targets
Role: Co-Investigator
Funding: NATL INST OF HLTH OD
Sep 2015 – May 2019
Tissue-Engineered Electronic Nerve Interface (TEENI)
Role: Project Manager
Funding: US DEPT OF DEFENSE DARPA
Apr 2015 – May 2018
Implantable Multimodal Peripheral Recording and Stimulation System (IMPRESS)
Role: Project Manager
Funding: US NAVY SPACE NAVAL WAR SYS CTR via US DEPT OF DEFENSE DARPA

Education

Post-doctoral Fellow/Neuroprostheses
2006 · University of Michigan
PhD/Bioengineering
2003 · Arizona State University
MS/Bioengineering
2002 · Arizona State University
BS/Chemical Engineering
1997 · Colorado State University

Contact Details

Phones:
Business:
(352) 294-2227
Emails:
Addresses:
Business Mailing:
P.O. BOX 116131
GAINESVILLE FL 326112023
Business Street:
P.O. Box 116131
1275 Center Drive, Biomedical Sciences Building JG56
Gainesville FL 32611