Jeremy C McIntyre

Jeremy C McIntyre,

Assistant Professor, Director Summer Neuroscience Internship Program

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 294-8266
Business Email: jmcin@ufl.edu

Research Profile

My Lab is broadly interested in the molecular mechanisms that underlie neuromodulation of various systems. The lab’s research focuses on the signaling function of the primary cilium and how it contributes to neuronal function. Our work focuses on several GPCRs that localize to the primary cilia that project from neuronal cell bodies. Cilia are critical for cellular function, and disruptions of cilia leads to numerous disease phenotypes, including developmental delays, intellectual disabilities and obesity. We are studying how primary cilia detect cues that alter neural function. In pursuit of these goals, we study sensory neurons in the nasal cavity that detect odors in the environment, neurons in the olfactory bulb that process olfactory information, and neuronal modulation in motivated and addictive behaviors. The lab currently has several ongoing projects. In the olfactory bulb, we are studying how physiological conditions, and associated neuropeptides such as melanin-concentrating hormone, affect odor processing. This work focuses on understanding how, produced by neurons in the hypothalamus, alters the perception of odors at the level of the olfactory bulb. Additionally, we are studying how primary cilia on neurons in the Nucleus Accumbens and Ventral Tegmental Area integrate signals that affect motivated behaviors and responses to drugs of addiction. To achieve these goals, we have developed several new mouse models to look at cell specific ablation of cilia and immunofluorescence and confocal microscopy, calcium imaging, electrophysiology, molecular biology and behavior.

Open Researcher and Contributor ID (ORCID)

0000-0001-8155-7166

Publications

2021
Cover Image
Journal of Neuroscience Research. 99(3) [DOI] 10.1002/jnr.24786.
2021
Inhibitory signaling in mammalian olfactory transduction potentially mediated by Gαo.
Molecular and cellular neurosciences. 110 [DOI] 10.1016/j.mcn.2020.103585. [PMID] 33358996.
2021
Neuron-specific cilia loss differentially alters locomotor responses to amphetamine in mice.
Journal of neuroscience research. 99(3):827-842 [DOI] 10.1002/jnr.24755. [PMID] 33175436.
2018
Peripheral Gene Therapeutic Rescue of an Olfactory Ciliopathy Restores Sensory Input, Axonal Pathfinding, and Odor-Guided Behavior
The Journal of Neuroscience. 38(34):7462-7475 [DOI] 10.1523/jneurosci.0084-18.2018.
2018
Peripheral Gene Therapeutic Rescue of an Olfactory Ciliopathy Restores Sensory Input, Axonal Pathfinding, and Odor-Guided Behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(34):7462-7475 [DOI] 10.1523/JNEUROSCI.0084-18.2018. [PMID] 30061191.
2017
Gene Therapeutic Reversal of Peripheral Olfactory Impairment in Bardet-Biedl Syndrome.
Molecular therapy : the journal of the American Society of Gene Therapy. 25(4):904-916 [DOI] 10.1016/j.ymthe.2017.02.006. [PMID] 28237838.
2017
Neuromodulation in Chemosensory Pathways.
Chemical senses. 42(5):375-379 [DOI] 10.1093/chemse/bjx014. [PMID] 28379355.
2016
Human spinal autografts of olfactory epithelial stem cells recapitulate donor site histology, maintaining proliferative and differentiation capacity many years after transplantation.
Acta neuropathologica. 131(4):639-40 [DOI] 10.1007/s00401-016-1543-3. [PMID] 26839081.
2016
Trafficking of ciliary G protein-coupled receptors.
Methods in cell biology. 132:35-54 [DOI] 10.1016/bs.mcb.2015.11.009. [PMID] 26928538.
2015
Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium
The Journal of Neuroscience. 35(40):13761-13772 [DOI] 10.1523/jneurosci.1708-15.2015.
2015
Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(40):13761-72 [DOI] 10.1523/JNEUROSCI.1708-15.2015. [PMID] 26446227.
2015
SUMOylation regulates ciliary localization of olfactory signaling proteins.
Journal of cell science. 128(10):1934-45 [DOI] 10.1242/jcs.164673. [PMID] 25908845.
2014
Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia.
Nature communications. 5 [DOI] 10.1038/ncomms6813. [PMID] 25504142.
2014
Role for myosin-V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes.
Circulation research. 114(6):982-92 [DOI] 10.1161/CIRCRESAHA.114.302711. [PMID] 24508725.
2013
Smelling the roses and seeing the light: gene therapy for ciliopathies.
Trends in biotechnology. 31(6):355-63 [DOI] 10.1016/j.tibtech.2013.03.005. [PMID] 23601268.
2012
Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis.
The Journal of clinical investigation. 122(4):1233-45 [DOI] 10.1172/JCI60981. [PMID] 22446187.
2012
Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model.
Nature medicine. 18(9):1423-8 [PMID] 22941275.
View on: PubMed
2011
Induction of Ran GTP drives ciliogenesis.
Molecular biology of the cell. 22(23):4539-48 [DOI] 10.1091/mbc.E11-03-0267. [PMID] 21998203.
2011
Subunit-dependent axonal trafficking of distinct alpha heteromeric potassium channel complexes.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(37):13224-35 [DOI] 10.1523/JNEUROSCI.0976-11.2011. [PMID] 21917805.
2010
Axon growth and guidance genes identify nascent, immature, and mature olfactory sensory neurons.
Journal of neuroscience research. 88(15):3243-56 [DOI] 10.1002/jnr.22497. [PMID] 20882566.
2008
Emx2 stimulates odorant receptor gene expression.
Chemical senses. 33(9):825-37 [DOI] 10.1093/chemse/bjn061. [PMID] 18854508.
2005
Differentially expressed transcripts from phenotypically identified olfactory sensory neurons.
The Journal of comparative neurology. 483(3):251-62 [PMID] 15682396.
View on: PubMed
2005
Transcriptional changes during neuronal death and replacement in the olfactory epithelium.
Molecular and cellular neurosciences. 30(4):583-600 [PMID] 16456926.
View on: PubMed
Neuron-specific cilia loss alters locomotor responses to amphetamine
. [DOI] 10.1101/2020.03.16.994087.

Grants

Apr 2021 ACTIVE
Centrifugal regulation of olfactory function by melanin-concentrating hormone
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCD
Apr 2021 ACTIVE
The contribution of declines in functional connectivity to cognitive aging
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Sep 2020 ACTIVE
Role of MCHR1 signaling in olfactory function
Role: Other
Funding: NATL INST OF HLTH NIDCD
Jun 2020 ACTIVE
1Florida Alzheimers Disease Research Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Jul 2019 ACTIVE
Novel neuromodulation of motivated and addictive behaviors
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
Dec 2015 – Nov 2019
Rescue of channelopathy induced anosmias
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCD
Jan 2014 – Oct 2015
Rescue of channelopathy induced anosmias
Role: Project Manager
Funding: NATL INST OF HLTH NIDCD

Education

PhD, Phsyiology
2002-2009 · University of Kentucky
BS, Neuroscience
1998-2001 · Bowling Green State University

Teaching Profile

Courses Taught
2014,2016-2021
GMS7794 Neuroscience Seminar
2016-2021
GMS7795 Special Topics in Neuroscience
2018-2020
GMS6022 Principles of Neuroscience II: Cellular and Molecular Neuroscience
2017-2021
GMS6705 Functional Human Neuroanatomy
2017-2019,2021
GMS6070 Sensory and Motor Systems
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research

Contact Details

Phones:
Business:
(352) 294-8266
Emails:
Business:
jmcin@ufl.edu