Carol Mathews

Carol Mathews, M.D.

Psychiatry Interim Chair & Professor

Department: MD-PSYCHIATRY
Business Phone: (352) 294-4900
Business Email: carolmathews@ufl.edu

About Carol Mathews

Dr. Mathews is the Brooke Professor and the Vice Chair for Strategic Development in the Department of Psychiatry at the University of Florida. Dr. Mathews completed her undergraduate education at Cornell University and her medical training at the Johns Hopkins School of Medicine. She subsequently did an internship and psychiatric residency at the University of California, San Francisco (UCSF), followed by research fellowships in biological psychiatry and clinical research methods. She spent 15 years as a clinician and research scientist at UCSD and UCSF before moving to the University of Florida in 2015.

Dr. Mathews is the Director of the Center for OCD, Anxiety, and Related Disorders at UF. Her research and clinical interests center around identifying the causes and neural underpinnings of obsessive compulsive and anxiety spectrum disorders, including OCD, hoarding disorder, tic disorders, and grooming disorders. She is actively engaged in studying the genetic causes of Tourette Syndrome (TS) and OC spectrum disorders, as well as examining how individuals with these disorders process information using standard neuropsychological assessments, electrophysiological methods such as EEG, and neuroimaging. She is also the principal investigator of a large study comparing community-based behavioral treatment for hoarding disorder to the current standard of care, group treatment by psychologists. She hopes that ultimately, this information will help to refine diagnosis, prevention, and intervention for these disorders. She serves on several advisory boards for non-profit organizations, including the Tourette Association of America, the International OCD Foundation, and the MHASF Task Force on Hoarding and Cluttering. She is also the chair of the TS/OCD Workgroup of the Psychiatric Genomics Consortium (PGC).

Accomplishments

Executive Leadership in Academic Medicine
2015 · Drexel University
Distinguished Fellow
2014 · American Psychiatric Association
Mentor of the Year
2013 · Pathways to Careers in Clinical & Translational Research, University of California, San Francisco
Mentor of the Year Nominee
2011 · Pathways to Careers in Clinical & Translational Research, University of California, San Francisco
Nominee, Dr. Martin Luther King Jr. Diversity Award
2011 · University of California, San Francisco
Resident Teaching Award PGY2 and PGY 3
2009 · University of California, San Francisco, Department of Psychiatry
Mid-Career Women Faculty Professional Development
2008 · Association of American Medical Colleges
Resident Teaching Award PGY2
2008 · University of California, San Francisco, Department of Psychiatry
Resident Teaching Award
2003 · University of California, San Diego, Department of Psychiatry
Young Investigator
2002 · National Association for Research on Schizophrenia and Depression
Future Leaders in Psychiatry Fellowship
2000 · American Psychiatric Association
Research Colloquium for Young Investigators
1997 · American Psychiatric Association
Creative Resident Award
1996 · University of California, San Francisco, Department of Psychiatry
Laughlin Fellowship
1996 · American College of Psychiatrists
Fellowship
1995 · West Coast College of Biological Psychiatry
CIBA-Geigy Award for Community Service in Medical School
1991 · Johns Hopkins School of Medicine

Board Certifications

  • Psychiatry
    American Board of Psychiatry and Neurology

Clinical Profile

Specialties
  • Psychiatry
Areas of Interest
  • Chronic motor or vocal tic disorder
  • Generalized anxiety disorder
  • Generalized anxiety disorder in children
  • Obsessive-compulsive disorder
  • Provisional tic disorder
  • Separation anxiety in children
  • Social anxiety disorder
  • Stress and your health
  • Tourette syndrome

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0003-2208-7058

Areas of Interest
  • Genetics
  • Hoarding
  • Neural phenotypes
  • Obsessive compulsive disorder
  • Pathophysiology
  • Tic disorders
  • Tourette Syndrome

Publications

2021
A dimensional perspective on the genetics of obsessive-compulsive disorder.
Translational psychiatry. 11(1) [DOI] 10.1038/s41398-021-01519-z. [PMID] 34290223.
2021
Acceptability, Feasibility, and Utility of Integrating Pharmacogenetic Testing into a Child Psychiatry Clinic.
Clinical and translational science. 14(2):589-598 [DOI] 10.1111/cts.12914. [PMID] 33166056.
2021
Contextualizing genetic risk score for disease screening and rare variant discovery.
Nature communications. 12(1) [DOI] 10.1038/s41467-021-24387-z. [PMID] 34285202.
2021
Electrophysiological dynamics of visuocortical processing in hoarding disorder.
Psychophysiology. 58(2) [DOI] 10.1111/psyp.13711. [PMID] 33128481.
2021
Elevated common variant genetic risk for tourette syndrome in a densely-affected pedigree.
Molecular psychiatry. [DOI] 10.1038/s41380-021-01277-w. [PMID] 34526668.
2021
Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits
Biological Psychiatry. 89(12):1127-1137 [DOI] 10.1016/j.biopsych.2020.12.024. [PMID] 33648717.
2021
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.
Nature genetics. 53(6):817-829 [DOI] 10.1038/s41588-021-00857-4. [PMID] 34002096.
2021
Hoarding disorder is associated with self-reported cardiovascular / metabolic dysfunction, chronic pain, and sleep apnea.
Journal of psychiatric research. 134:15-21 [DOI] 10.1016/j.jpsychires.2020.12.032. [PMID] 33360440.
2021
Impact of the COVID-19 Pandemic on Disordered Eating Behavior: Qualitative Analysis of Social Media Posts.
JMIR mental health. 8(1) [DOI] 10.2196/26011. [PMID] 33465035.
2021
Inside OCD: Perspectives on the Value of Storytelling with Individuals with OCD and Family Members.
Healthcare (Basel, Switzerland). 9(8) [DOI] 10.3390/healthcare9080920. [PMID] 34442057.
2021
Investigating shared genetic basis across Tourette Syndrome and comorbid neurodevelopmental disorders along the impulsivity-compulsivity spectrum
Biological Psychiatry. 90(5):317-327 [DOI] 10.1016/j.biopsych.2020.12.028. [PMID] 33714545.
2021
Investigation of gene-environment interactions in relation to tic severity.
Journal of neural transmission (Vienna, Austria : 1996). [DOI] 10.1007/s00702-021-02396-y. [PMID] 34389898.
2021
Is Persistent Motor or Vocal Tic Disorder a Milder Form of Tourette Syndrome?
Movement disorders : official journal of the Movement Disorder Society. 36(8):1899-1910 [DOI] 10.1002/mds.28593. [PMID] 33942911.
2021
Specialty knowledge and competency standards for pharmacotherapy for adult obsessive-compulsive disorder.
Psychiatry research. 300 [DOI] 10.1016/j.psychres.2021.113853. [PMID] 33975093.
2021
Synaptic processes and immune-related pathways implicated in Tourette syndrome.
Translational psychiatry. 11(1) [DOI] 10.1038/s41398-020-01082-z. [PMID] 33462189.
2021
Thoughtful Clinical Use of Pharmacogenetics in Child and Adolescent Psychopharmacology.
Journal of the American Academy of Child and Adolescent Psychiatry. 60(6):660-664 [DOI] 10.1016/j.jaac.2020.08.006. [PMID] 32860906.
2020
Disordered eating is associated with non-medical use of prescription stimulants among college students.
Drug and alcohol dependence. 209 [DOI] 10.1016/j.drugalcdep.2020.107907. [PMID] 32088588.
2020
Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder.
Molecular psychiatry. 25(9):2036-2046 [DOI] 10.1038/s41380-018-0115-4. [PMID] 30087453.
2020
Internet-based hoarding assessment: The reliability and predictive validity of the internet-based Hoarding Rating Scale, Self-Report.
Psychiatry research. 294 [DOI] 10.1016/j.psychres.2020.113505. [PMID] 33070108.
2020
Psychological Resilience as a Protective Factor for Depression and Anxiety Among the Public During the Outbreak of COVID-19.
Frontiers in psychology. 11 [DOI] 10.3389/fpsyg.2020.618509. [PMID] 33551929.
2020
Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling.
Translational psychiatry. 10(1) [DOI] 10.1038/s41398-020-0793-y. [PMID] 32341337.
2020
Treating hoarding disorder with compassion-focused therapy: A pilot study examining treatment feasibility, acceptability, and exploring treatment effects.
The British journal of clinical psychology. 59(1):1-21 [DOI] 10.1111/bjc.12228. [PMID] 31271462.
2020
Visually mediated functioning improves following treatment of hoarding disorder.
Journal of affective disorders. 264:310-317 [DOI] 10.1016/j.jad.2019.12.030. [PMID] 32056766.
2019
Challenges and lessons learned from clinical pharmacogenetic implementation of multiple gene-drug pairs across ambulatory care settings.
Genetics in medicine : official journal of the American College of Medical Genetics. 21(10):2264-2274 [DOI] 10.1038/s41436-019-0500-7. [PMID] 30926959.
2019
Comparing Peer-Led Support Groups with Therapist-Led Support Groups for Treating Hoarding Disorder
. [DOI] 10.25302/5.2019.ce.13046000.
2019
Concordance of genetic variation that increases risk for tourette syndrome and that influences its underlying neurocircuitry.
Translational psychiatry. 9(1) [DOI] 10.1038/s41398-019-0452-3. [PMID] 30902966.
2019
Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps.
Biological psychiatry. 85(9):713-725 [DOI] 10.1016/j.biopsych.2018.11.010. [PMID] 30595231.
2019
Hoarding: A meta-analysis of age of onset.
Depression and anxiety. 36(6):552-564 [DOI] 10.1002/da.22896. [PMID] 30958911.
2019
Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
The American journal of psychiatry. 176(3):217-227 [DOI] 10.1176/appi.ajp.2018.18070857. [PMID] 30818990.
2019
Polygenic Risk Scores Derived From a Tourette Syndrome Genome-wide Association Study Predict Presence of Tics in the Avon Longitudinal Study of Parents and Children Cohort.
Biological psychiatry. 85(4):298-304 [DOI] 10.1016/j.biopsych.2018.09.011. [PMID] 30424865.
2019
Tourette disorder and other tic disorders.
Handbook of clinical neurology. 165:123-153 [DOI] 10.1016/B978-0-444-64012-3.00008-3. [PMID] 31727209.
2018
Analysis of shared heritability in common disorders of the brain
Science. 360(6395) [DOI] 10.1126/science.aap8757. [PMID] 29930110.
2018
Contributions of self-criticism and shame to hoarding.
Psychiatry research. 262:488-493 [DOI] 10.1016/j.psychres.2017.09.030. [PMID] 28939393.
2018
De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis.
Cell reports. 24(13):3441-3454.e12 [DOI] 10.1016/j.celrep.2018.08.082. [PMID] 30257206.
2018
Deficits in physiological and self-conscious emotional response to errors in hoarding disorder.
Psychiatry research. 268:157-164 [DOI] 10.1016/j.psychres.2018.07.012. [PMID] 30029063.
2018
Detail-oriented visual processing style: Its role in the relationships between early life adversity and hoarding-related dysfunctions
Psychiatry research. 267:30-36 [DOI] 10.1016/j.psychres.2018.05.053. [PMID] 29883858.
2018
Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome.
Psychological medicine. 48(2):279-293 [DOI] 10.1017/S0033291717001672. [PMID] 28651666.
2018
Prevalence and predictors of hair pulling disorder and excoriation disorder in Tourette syndrome.
European child & adolescent psychiatry. 27(5):569-579 [DOI] 10.1007/s00787-017-1074-z. [PMID] 29098466.
2018
Psychiatric Genomics: An Update and an Agenda.
The American journal of psychiatry. 175(1):15-27 [DOI] 10.1176/appi.ajp.2017.17030283. [PMID] 28969442.
2018
Randomised clinical trial of community-based peer-led and psychologist-led group treatment for hoarding disorder
BJPsych Open. 4(4):285-293 [DOI] 10.1192/bjo.2018.30. [PMID] 30083381.
2018
Recruiting under-represented populations into psychiatric research: Results from the help for hoarding study.
Contemporary clinical trials communications. 12:169-175 [DOI] 10.1016/j.conctc.2018.11.003. [PMID] 30480164.
2018
Relationship between symptom severity, psychiatric comorbidity, social/occupational impairment, and suicidality in hoarding disorder
Journal of Obsessive-Compulsive and Related Disorders. 21:158-164
2017
A 9-Year-Old Girl With Persistent Obsessive and Compulsive Behaviors in a Primary Care Pediatric Practice.
Journal of developmental and behavioral pediatrics : JDBP. 38 Suppl 1:S12-S15 [DOI] 10.1097/DBP.0000000000000150. [PMID] 28141709.
2017
A model-based analysis of decision making under risk in obsessive-compulsive and hoarding disorders.
Journal of psychiatric research. 90:126-132 [DOI] 10.1016/j.jpsychires.2017.02.017. [PMID] 28279877.
2017
Age-Specific Prevalence of Hoarding and Obsessive Compulsive Disorder: A Population-Based Study.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 25(3):245-255 [DOI] 10.1016/j.jagp.2016.11.006. [PMID] 27939851.
2017
Autism Spectrum Symptoms in a Tourette’s Disorder Sample.
Journal of the American Academy of Child and Adolescent Psychiatry. 56(7):610-617.e1 [DOI] 10.1016/j.jaac.2017.05.002. [PMID] 28647013.
2017
De Novo Coding Variants Are Strongly Associated with Tourette Disorder.
Neuron. 94(3):486-499.e9 [DOI] 10.1016/j.neuron.2017.04.024. [PMID] 28472652.
2017
Deep Brain Stimulation for Obsessive-Compulsive Disorder-Reply.
JAMA. 318(4) [DOI] 10.1001/jama.2017.7873. [PMID] 28742903.
2017
Gilles de la Tourette syndrome.
Nature reviews. Disease primers. 3 [DOI] 10.1038/nrdp.2016.97. [PMID] 28150698.
2017
Heritability of tic disorders: a twin-family study.
Psychological medicine. 47(6):1085-1096 [DOI] 10.1017/S0033291716002981. [PMID] 27974054.
2017
Identification of Two Heritable Cross-Disorder Endophenotypes for Tourette Syndrome.
The American journal of psychiatry. 174(4):387-396 [DOI] 10.1176/appi.ajp.2016.16020240. [PMID] 27809572.
2017
Institutional profile: University of Florida Health Personalized Medicine Program.
Pharmacogenomics. 18(5):421-426 [DOI] 10.2217/pgs-2017-0028. [PMID] 28346068.
2017
Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder.
Nature communications. 8(1) [DOI] 10.1038/s41467-017-00831-x. [PMID] 29042551.
2017
Obsessive-Compulsive Disorder: Advances in Diagnosis and Treatment.
JAMA. 317(13):1358-1367 [DOI] 10.1001/jama.2017.2200. [PMID] 28384832.
2017
Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring: A Nationwide Case-Control Study.
Journal of the American Academy of Child and Adolescent Psychiatry. 56(4):297-303.e4 [DOI] 10.1016/j.jaac.2017.01.009. [PMID] 28335873.
2017
Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome.
Neuron. 94(6):1101-1111.e7 [DOI] 10.1016/j.neuron.2017.06.010. [PMID] 28641109.
2017
Rare Synaptogenesis-Impairing Mutations in SLITRK5 Are Associated with Obsessive Compulsive Disorder
PLoS One. 12(1)
2017
Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis
Molecular Psychiatry. 23(5):1181-1188
2017
The Role of Regional Conferences in Research Resident Career Development: The California Psychiatry Research Resident Retreat.
Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry. 41(2):272-277 [DOI] 10.1007/s40596-016-0562-7. [PMID] 27178277.
2016
Analysis of protein-coding genetic variation in 60,706 humans
Nature. 536(7616):285-291
2016
Clinical Correlates of Hoarding With and Without Comorbid Obsessive-Compulsive Symptoms in a Community Pediatric Sample.
Journal of the American Academy of Child and Adolescent Psychiatry. 55(2):114-21.e2 [DOI] 10.1016/j.jaac.2015.11.014. [PMID] 26802778.
2016
Comparison of a peer facilitated support group to cognitive behavior therapy: Study protocol for a randomized controlled trial for hoarding disorder.
Contemporary clinical trials. 50:98-105 [DOI] 10.1016/j.cct.2016.07.018. [PMID] 27444427.
2016
Comparison of brain activation patterns during executive function tasks in hoarding disorder and non-hoarding OCD.
Psychiatry research. Neuroimaging. 255:50-9 [DOI] 10.1016/j.pscychresns.2016.07.007. [PMID] 27522332.
2016
Error-Related Brain Activity Dissociates Hoarding Disorder From Obsessive-Compulsive Disorder
Psychological Medicine. 46(2):367-79 [DOI] 10.1017/S0033291715001889. [PMID] 26415671.
2016
Hazardous drinking among young adults seeking outpatient mental health services.
Addiction science & clinical practice. 11(1) [DOI] 10.1186/s13722-016-0060-y. [PMID] 27506832.
2016
Patterns of clinically significant cognitive impairment in hoarding disorder
Depression and Anxiety. 33:211-218
2016
Social disinhibition is a heritable subphenotype of tics in Tourette syndrome.
Neurology. 87(5):497-504 [DOI] 10.1212/WNL.0000000000002910. [PMID] 27371487.
2016
The Association Between Psychiatric Disorders and Telomere Length: A Meta-Analysis Involving 14,827 Persons.
Psychosomatic medicine. 78(7):776-87 [DOI] 10.1097/PSY.0000000000000356. [PMID] 27359174.
2016
The First World Congress on Tourette Syndrome and Tic Disorders: Controversies and Hot Topics in Etiology and Treatment.
Frontiers in neuroscience. 10 [DOI] 10.3389/fnins.2016.00246. [PMID] 27375411.
2016
The Genetic Etiology of Tourette Syndrome: Large-Scale Collaborative Efforts on the Precipice of Discovery
Frontiers in Neuroscience. 10 [DOI] 10.3389/fnins.2016.00357. [PMID] 27536213.
2016
The Genetic Etiology of Tourette Syndrome: Large-Scale Collaborative Efforts on the Precipice of Discovery.
Frontiers in neuroscience. 10 [DOI] 10.3389/fnins.2016.00351. [PMID] 27536211.
2016
The relationship between tics, OC, ADHD, and autism symptoms: A cross-disorder symptom analysis in Gilles de la Tourette syndrome patients and family-members
Psychiatry Research. 237:138-146
2016
Treating Hoarding Disorder in a real-world setting: Results from the Mental Health Association of San Francisco
Psychiatry research (Online). 331-8 [DOI] 10.1016/j.psychres.2016.01.019. [PMID] 26805562.
2016
Treating Hoarding Disorder in a real-world setting: Results from the Mental Health Association of San Francisco.
Psychiatry research. 237:331-8 [DOI] 10.1016/j.psychres.2016.01.019. [PMID] 26805562.
2015
COMT and MAO-A polymorphisms and obsessive-compulsive disorder: a family-based association study.
PloS one. 10(3) [DOI] 10.1371/journal.pone.0119592. [PMID] 25793616.
2015
Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette’s syndrome and OCD.
The American journal of psychiatry. 172(1):82-93 [DOI] 10.1176/appi.ajp.2014.13101306. [PMID] 25158072.
2015
Identification of the hikikomori syndrome of social withdrawal: Psychosocial features and treatment preferences in four countries.
The International journal of social psychiatry. 61(1):64-72 [DOI] 10.1177/0020764014535758. [PMID] 24869848.
2015
Involvement of astrocyte metabolic coupling in Tourette syndrome pathogenesis.
European journal of human genetics : EJHG. 23(11):1519-22 [DOI] 10.1038/ejhg.2015.22. [PMID] 25735483.
2015
Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome.
JAMA psychiatry. 72(4):325-33 [DOI] 10.1001/jamapsychiatry.2014.2650. [PMID] 25671412.
2015
Neuropsychological and dimensional behavioral trait profiles in Costa Rican ADHD sib pairs: Potential intermediate phenotypes for genetic studies.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 168B(4):247-57 [DOI] 10.1002/ajmg.b.32305. [PMID] 25832558.
2015
Parental mood during pregnancy and post-natally is associated with offspring risk of Tourette syndrome or chronic tics: prospective data from the Avon Longitudinal Study of Parents and Children
European Child & Adolescent Psychiatry. 25(373):373-381
2015
Population prevalence of Tourette syndrome: a systematic review and meta-analysis.
Movement disorders : official journal of the Movement Disorder Society. 30(2):221-8 [DOI] 10.1002/mds.26089. [PMID] 25487709.
2015
Tic symptom dimensions and their heritabilities in Tourette’s syndrome
Psychiatric Genetics. 25(3):112-118
2015
Tourette Syndrome: Complementary Insights from Measures of Cognitive Control, Eyeblink Rate, and Pupil Diameter
. 6(95)
2015
Web-based phenotyping for Tourette Syndrome: Reliability of common co-morbid diagnoses.
Psychiatry research. 228(3):816-25 [DOI] 10.1016/j.psychres.2015.05.017. [PMID] 26054936.
2014
Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort.
. 204(5):40-45
2014
Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort.
The British journal of psychiatry : the journal of mental science. 204(1):40-5 [DOI] 10.1192/bjp.bp.112.125468. [PMID] 24262815.
2014
Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study.
Journal of the American Academy of Child and Adolescent Psychiatry. 53(8):910-9 [DOI] 10.1016/j.jaac.2014.04.022. [PMID] 25062598.
2014
Genetic association signal near NTN4 in Tourette syndrome.
Annals of neurology. 76(2):310-5 [DOI] 10.1002/ana.24215. [PMID] 25042818.
2014
Hoarding disorder: more than just a problem of too much stuff.
The Journal of clinical psychiatry. 75(8):893-4 [DOI] 10.4088/JCP.14ac09325. [PMID] 25191909.
2014
Partitioning the etiology of hoarding and obsessive-compulsive symptoms.
Psychological medicine. 44(13):2867-76 [DOI] 10.1017/S0033291714000269. [PMID] 25066062.
2014
The Inheritance of Tourette Disorder: A review.
Journal of obsessive-compulsive and related disorders. 3(4):380-385 [PMID] 25506544.
View on: PubMed
2014
Tourette syndrome and chronic tic disorder are associated with lower socio-economic status: findings from the Avon Longitudinal Study of Parents and Children cohort.
Developmental medicine and child neurology. 56(2):157-63 [DOI] 10.1111/dmcn.12318. [PMID] 24138188.
2013
CNV analysis in Tourette syndrome implicates large genomic rearrangements in COL8A1 and NRXN1.
PloS one. 8(3) [DOI] 10.1371/journal.pone.0059061. [PMID] 23533600.
2013
Eleven-year outcomes from an integrated residency program to train research psychiatrists
Academic Emergency Medicine. 88(7):983-988
2013
Eleven-year outcomes from an integrated residency program to train research psychiatrists.
Academic medicine : journal of the Association of American Medical Colleges. 88(7):983-8 [DOI] 10.1097/ACM.0b013e318294f95d. [PMID] 23702520.
2013
Genome-wide association study of obsessive-compulsive disorder.
Molecular psychiatry. 18(7):788-98 [DOI] 10.1038/mp.2012.85. [PMID] 22889921.
2013
Genome-wide association study of Tourette’s syndrome.
Molecular psychiatry. 18(6):721-8 [DOI] 10.1038/mp.2012.69. [PMID] 22889924.
2013
Meta-analysis of association between obsessive-compulsive disorder and the 3′ region of neuronal glutamate transporter gene SLC1A1.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 162B(4):367-79 [DOI] 10.1002/ajmg.b.32137. [PMID] 23606572.
2013
Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.
PLoS genetics. 9(10) [DOI] 10.1371/journal.pgen.1003864. [PMID] 24204291.
2013
Prevalence and clinical correlates of explosive outbursts in Tourette syndrome.
Psychiatry research. 205(3):269-75 [DOI] 10.1016/j.psychres.2012.09.029. [PMID] 23040794.
2012
Characteristics and comorbidity of ADHD sib pairs in the Central Valley of Costa Rica.
Comprehensive psychiatry. 53(4):379-86 [DOI] 10.1016/j.comppsych.2011.05.003. [PMID] 21696714.
2012
Effectiveness of a web-based protocol for the screening and phenotyping of individuals with Tourette syndrome for genetic studies.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 159B(8):987-96 [DOI] 10.1002/ajmg.b.32107. [PMID] 23090870.
2012
Error-related negativity in individuals with obsessive-compulsive symptoms: Toward an understanding of hoarding behaviors
Biological Psychiatry. 89(2):487-494
2012
Error-related negativity in individuals with obsessive-compulsive symptoms: toward an understanding of hoarding behaviors.
Biological psychology. 89(2):487-94 [DOI] 10.1016/j.biopsycho.2011.12.018. [PMID] 22227169.
2012
Genome-wide linkage analysis of obsessive-compulsive disorder implicates chromosome 1p36.
Biological psychiatry. 72(8):629-36 [DOI] 10.1016/j.biopsych.2012.03.037. [PMID] 22633946.
2012
Prevalence of Tourette syndrome and chronic tics in the population-based Avon longitudinal study of parents and children cohort.
Journal of the American Academy of Child and Adolescent Psychiatry. 51(2):192-201.e5 [DOI] 10.1016/j.jaac.2011.11.004. [PMID] 22265365.
2011
[Prevalence of and screening for ADHD in Costa Rica].
Vertex (Buenos Aires, Argentina). 22(99):337-42 [PMID] 22432094.
View on: PubMed
2011
Brain-derived neurotrophic factor (BDNF) plasma levels in drug-naïve OCD patients are lower than those in healthy people, but are not lower than those in drug-treated OCD patients.
Journal of affective disorders. 133(1-2):305-10 [DOI] 10.1016/j.jad.2011.04.002. [PMID] 21616543.
2011
Cognitive functioning in individuals with severe compulsive hoarding behaviors and late life depression.
International journal of geriatric psychiatry. 26(3):314-21 [DOI] 10.1002/gps.2531. [PMID] 21319334.
2011
Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: heritability analysis in a large sib-pair sample.
Journal of the American Academy of Child and Adolescent Psychiatry. 50(1):46-54 [DOI] 10.1016/j.jaac.2010.10.004. [PMID] 21156269.
2011
Family-based genetic association study of DLGAP3 in Tourette Syndrome
American Journal of Medical Genetics. 156(1):108-114
2011
Genomewide linkage analysis in Costa Rican families implicates chromosome 15q14 as a candidate region for OCD.
Human genetics. 130(6):795-805 [DOI] 10.1007/s00439-011-1033-6. [PMID] 21691774.
2011
Latent class analysis of the Yale-Brown Obsessive-Compulsive Scale symptoms in obsessive-compulsive disorder.
Comprehensive psychiatry. 52(3):334-41 [DOI] 10.1016/j.comppsych.2010.06.007. [PMID] 21145539.
2011
The threshold hypothesis: solving the equation of nurture vs nature in type 1 diabetes.
Diabetologia. 54(9):2232-6 [DOI] 10.1007/s00125-011-2244-z. [PMID] 21773685.
2010
Linkage analysis of Tourette syndrome in a large Utah pedigree
American Journal of Medical Genetics. 153(2):656-662
2010
ADHD prevalence and association with hoarding behaviors in childhood-onset OCD.
Depression and anxiety. 27(7):667-74 [DOI] 10.1002/da.20691. [PMID] 20583294.
2010
Copy number variation in Tourette syndrome: another case of neurodevelopmental generalist genes?
Neurology. 74(20):1564-5 [DOI] 10.1212/WNL.0b013e3181e24161. [PMID] 20427746.
2010
Symptom dimensions in OCD: item-level factor analysis and heritability estimates.
Behavior genetics. 40(4):505-17 [DOI] 10.1007/s10519-010-9339-z. [PMID] 20361247.
2009
A narrow and highly significant linkage signal for severe bipolar disorder in the chromosome 5q33 region in Latin American pedigrees.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 150B(7):998-1006 [DOI] 10.1002/ajmg.b.30956. [PMID] 19319892.
2009
Clinical phenomenology and phenotype variability in Tourette syndrome.
Journal of psychosomatic research. 67(6):491-6 [DOI] 10.1016/j.jpsychores.2009.07.011. [PMID] 19913653.
2008
A comparative study of obsessive-compulsive disorder in Costa Rica and the United States.
Depression and anxiety. 25(7):609-19 [PMID] 17823962.
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2008
Childhood trauma and obsessive-compulsive symptoms.
Depression and anxiety. 25(9):742-51 [PMID] 17557315.
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2008
Evidence for a heritable unidimensional symptom factor underlying obsessionality.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 147B(6):676-85 [DOI] 10.1002/ajmg.b.30660. [PMID] 18163383.
2008
Lack of association between SLITRK1var321 and Tourette syndrome in a large family-based sample
Neurology. 70:1495-1496
2008
Latent class analysis of gilles de la tourette syndrome using comorbidities: clinical and genetic implications.
Biological psychiatry. 64(3):219-25 [DOI] 10.1016/j.biopsych.2008.01.019. [PMID] 18359008.
2007
Anxiety symptoms and perceived performance in medical students.
Depression and anxiety. 24(2):103-11 [PMID] 16845642.
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2007
Heritability and clinical features of multigenerational families with obsessive-compulsive disorder and hoarding.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 144B(2):174-82 [PMID] 17290446.
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2007
Tic symptom profiles in subjects with Tourette Syndrome from two genetically isolated populations.
Biological psychiatry. 61(3):292-300 [PMID] 16581034.
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2006
Association between maternal smoking and increased symptom severity in Tourette’s syndrome.
The American journal of psychiatry. 163(6):1066-73 [PMID] 16741208.
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2006
Convergent linkage evidence from two Latin-American population isolates supports the presence of a susceptibility locus for bipolar disorder in 5q31-34.
Human molecular genetics. 15(21):3146-53 [PMID] 16984960.
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2006
Genome Scan for Tourette’s Disorder in Affected Sib-Pair and Multigenerational Families
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2006
Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analyses.
Human molecular genetics. 15(22):3324-8 [PMID] 17035247.
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2006
Results of a SNP genome screen in a large Costa Rican pedigree segregating for severe bipolar disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 141B(4):367-73 [PMID] 16652356.
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2005
Sequence variants in SLITRK1 are associated with Tourette’s syndrome.
Science (New York, N.Y.). 310(5746):317-20 [PMID] 16224024.
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2004
Genetic Studies of Neuropsychiatric Disorders in Central America. Psychiatric Genetics
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2004
Genetic studies of neuropsychiatric disorders in Costa Rica: a model for the use of isolated populations.
Psychiatric genetics. 14(1):13-23 [PMID] 15091311.
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2004
Self injurious behaviour in Tourette syndrome: correlates with impulsivity and impulse control.
Journal of neurology, neurosurgery, and psychiatry. 75(8):1149-55 [PMID] 15258218.
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2004
The structure of obsessionality among young adults.
Depression and anxiety. 20(2):77-85 [PMID] 15468097.
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2003
CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder
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CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder.
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2003
Genetic linkage in bipolar disorder.
CNS spectrums. 8(12):891-904 [PMID] 14978466.
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2003
Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 123B(1):64-9 [PMID] 14582147.
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2002
Comorbidity of bipolar disorder and substance abuse in Costa Rica: pedigree- and population-based studies.
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2002
Genome Wide Scan of Hoarding in Sibling Pairs Both Diagnosed with Gilles de la Tourette Syndrome
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Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolate
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Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolate.
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2002
Improving the accessibility of condoms in South Africa: the role of informal distribution.
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The effect on diagnostic rates of assigning patients to ethnically focused inpatient psychiatric units.
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The effect on treatment outcomes of assigning patients to ethnically focused inpatient psychiatric units.
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2001
Assortative mating in the affective disorders: a systematic review and meta-analysis.
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2001
Cultural influences on diagnosis and perception of Tourette syndrome in Costa Rica.
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2001
Fine-scale mapping of a locus for severe bipolar mood disorder on chromosome 18p11.3 in the Costa Rican population.
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Genome screening for linkage disequilibrium in a Costa Rican sample of patients with bipolar-I disorder: a follow-up study on chromosome 18
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Grants

Aug 2021 ACTIVE
SF2UF: The Bridges to the Baccalaureate partnership between Santa Fe College and the University of Florida
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Aug 2021 ACTIVE
Acquisition, extinction, and recall of attention biases to threat: Computational modeling and multimodal brain imaging
Role: Co-Investigator
Funding: NATL INST OF HLTH NIMH
Sep 2019 – Aug 2021
A phased clinical trial of a dietary supplement kava: biomarker changes and anxiolytic effects
Role: Principal Investigator
Funding: NATL CTR FOR COMPLEM AND INTEGRATIVE HLT
Apr 2019 ACTIVE
Large-Scale Collaborative Genetic and Epigenetic Studies of Tourette Syndrome
Role: Principal Investigator
Funding: MASSACHUSETTS GENERAL HOSPITAL via NATL INST OF HLTH NINDS
Sep 2018 ACTIVE
Sparking Advancements in Genomic Medicine?
Role: Project Manager
Funding: NATL INST OF HLTH NHGRI
Jul 2018 ACTIVE
Hoarding disorder in older adults: cognition, etiology and functional impact
Role: Principal Investigator
Funding: NATL INST OF HLTH NIMH
Mar 2018 ACTIVE
Integrating Common and Rare Variation to Discover Genes with Tourette Syndrome
Role: Principal Investigator
Funding: MASSACHUSETTS GENERAL HOSPITAL via NATL INST OF HLTH NINDS
Jul 2016 – Mar 2019
2/7 Psychiatric Genomics Consortium: Finding actionable variation
Role: Principal Investigator
Funding: MASSACHUSETTS GENERAL HOSPITAL via NATL INST OF HLTH NIMH
Apr 2016 – Mar 2017
TOGETHER: TRANSFORMING AND TRANSLATING DISCOVERY TO IMPROVE HEALTH ,
Role: Project Manager
Funding: NATL INST OF HLTH NCATS
Aug 2015 – Jun 2021
CTSI Institutional Support
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Aug 2015 – Jul 2017
Comparison of Peer Facilitated Support Group and Cognitive Behavioral Therapy for Hoarding Disorder
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via PATIENT-CENTERED OUTCOMES RES INST
Aug 2015 – Nov 2016
REFINING THE TOURETTE SYNDROME PHENOTYPE ACROSS DIAGNOSESTO AID GENE DISCOVERY
Role: Principal Investigator
Funding: NATL INST OF HLTH NIMH
Apr 2015 – Jun 2021
Clinical and Translational Science Institute (CTSI)
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS

Education

Fellowship – Psychiatry
2000 · University of California, San Francisco
Residency – Psychiatry
1996 · University of California, San Francisco
Internship – Psychiatry
1993 · University of California, San Francisco
Medical Degree
1992 · Johns Hopkins University
Bachelor's Degree
1988 · Cornell University

Teaching Profile

Courses Taught
2018
GMS7979 Advanced Research
2016
GMS7794 Neuroscience Seminar
2021
PHC7918 Independent Study

Contact Details

Phones:
Business:
(352) 294-4900
Emails: