Christian Lessard

Christian Lessard,

RES AST PROF

Department: Department of Neuroscience
Business Phone: (352) 273-9690
Business Email: chles60@ufl.edu

Publications

2022
Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways.
Alzheimer's research & therapy. [DOI] 10.1186/s13195-022-01044-1. [PMID] 35897046.
2021
Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions.
Acta neuropathologica. [DOI] 10.1007/s00401-021-02264-9. [PMID] 33496840.
2020
γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.
Alzheimer's research & therapy. [DOI] 10.1186/s13195-020-00622-5. [PMID] 32430033.
2019
Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph.
Alzheimer's research & therapy. [DOI] 10.1186/s13195-019-0469-0. [PMID] 30711010.
2019
Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
The Journal of biological chemistry. [DOI] 10.1074/jbc.RA119.008041. [PMID] 31167792.
2018
High-affinity interactions and signal transduction between Aβ oligomers and TREM2.
EMBO molecular medicine. [DOI] 10.15252/emmm.201809027. [PMID] 30341064.
2017
γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.
EMBO molecular medicine. [DOI] 10.15252/emmm.201607265. [PMID] 28539479.
2015
γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP).
PloS one. [DOI] 10.1371/journal.pone.0144758. [PMID] 26678856.
2011
Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.
The Journal of biological chemistry. [DOI] 10.1074/jbc.M111.277228. [PMID] 21868380.
2010
And four equals one: presenilin takes the gamma-secretase role by itself.
Proceedings of the National Academy of Sciences of the United States of America. [DOI] 10.1073/pnas.1016284108. [PMID] 21135249.
2005
The overexpression of presenilin2 and Alzheimer’s-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells.
Cellular signalling. [PMID] 15601622.

Grants

Feb 2022 ACTIVE
Contributions of tau-mediated translational dysregulation to pathogenesis and progression of fronto-temporal dementia
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Dec 2021 ACTIVE
Establishing the role of PERK activation on the progression of tauopathy
Role: Co-Investigator
Funding: ALZHEIMERS ASSO
Sep 2021 ACTIVE
The molecular intersection of tau, TBI, and PERK
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Jul 2021 ACTIVE
Tau-ribosome interactions are a fundamental pathogenic event in Alzheimers disease and related tauopathies
Role: Co-Investigator
Funding: COINS FOR ALZHEIMERS RESEARCH TRUST

Contact Details

Phones:
Business:
(352) 273-9690
Emails:
Business:
chles60@ufl.edu
Addresses:
Business Mailing:
PO Box 100159
GAINESVILLE FL 32610
Business Street:
1275 CENTER DR
DEPT. OF NEUROSCIENCE/CTRND
GAINESVILLE FL 326103007