Christian Lessard,
RES AST PROF
Department:
Department of Neuroscience
Business Phone:
(352) 273-9690
Business Email:
chles60@ufl.edu
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0003-1249-3028
Publications
2022
Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways.
Alzheimer's research & therapy.
14(1)
[DOI] 10.1186/s13195-022-01044-1.
[PMID] 35897046.
2021
Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions.
Acta neuropathologica.
141(3):359-381
[DOI] 10.1007/s00401-021-02264-9.
[PMID] 33496840.
2020
γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.
Alzheimer's research & therapy.
12(1)
[DOI] 10.1186/s13195-020-00622-5.
[PMID] 32430033.
2019
Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph.
Alzheimer's research & therapy.
11(1)
[DOI] 10.1186/s13195-019-0469-0.
[PMID] 30711010.
2019
Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
The Journal of biological chemistry.
294(29):11276-11285
[DOI] 10.1074/jbc.RA119.008041.
[PMID] 31167792.
2018
High-affinity interactions and signal transduction between Aβ oligomers and TREM2.
EMBO molecular medicine.
10(11)
[DOI] 10.15252/emmm.201809027.
[PMID] 30341064.
2017
γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.
EMBO molecular medicine.
9(7):950-966
[DOI] 10.15252/emmm.201607265.
[PMID] 28539479.
2015
γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP).
PloS one.
10(12)
[DOI] 10.1371/journal.pone.0144758.
[PMID] 26678856.
2011
Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.
The Journal of biological chemistry.
286(46):39794-803
[DOI] 10.1074/jbc.M111.277228.
[PMID] 21868380.
2010
And four equals one: presenilin takes the gamma-secretase role by itself.
Proceedings of the National Academy of Sciences of the United States of America.
107(50):21236-7
[DOI] 10.1073/pnas.1016284108.
[PMID] 21135249.
2005
The overexpression of presenilin2 and Alzheimer’s-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells.
Cellular signalling.
17(4):437-45
[PMID] 15601622.
Grants
Feb 2022
ACTIVE
Contributions of tau-mediated translational dysregulation to pathogenesis and progression of fronto-temporal dementia
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Dec 2021
ACTIVE
Establishing the role of PERK activation on the progression of tauopathy
Role: Co-Investigator
Funding: ALZHEIMERS ASSO
Sep 2021
ACTIVE
The molecular intersection of tau, TBI, and PERK
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Jul 2021
ACTIVE
Tau-ribosome interactions are a fundamental pathogenic event in Alzheimers disease and related tauopathies
Role: Co-Investigator
Funding: COINS FOR ALZHEIMERS RESEARCH TRUST
Contact Details
Phones:
- Business:
- (352) 273-9690
Emails:
- Business:
- chles60@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100159
GAINESVILLE FL 32610 - Business Street:
-
1275 CENTER DR
DEPT. OF NEUROSCIENCE/CTRND
GAINESVILLE FL 326103007