John Koren,
RES AST PROF
Department:
Department of Neuroscience
Business Phone:
(352) 273-7538
Business Email:
jkoren@ufl.edu
Teaching Profile
Courses Taught
2022-2023
GMS6757 Introduction to Alzheimer’s Disease and Related Dementias: Clinical and Mechanistic Principles
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-6017-1763
Publications
Academic Articles
2023
Fixed Time-Point Analysis Reveals Repetitive Mild Traumatic Brain Injury Effects on Resting State Functional Magnetic Resonance Imaging Connectivity and Neuro-Spatial Protein Profiles.
Journal of neurotrauma.
40(19-20):2037-2049
[DOI] 10.1089/neu.2022.0464.
[PMID] 37051703.
2021
Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy.
International journal of molecular sciences.
22(3)
[DOI] 10.3390/ijms22031186.
[PMID] 33530349.
2021
Effects of altered tau expression on dentate granule cell excitability in mice.
Experimental neurology.
343
[DOI] 10.1016/j.expneurol.2021.113766.
[PMID] 34029610.
2018
Hsp90 and FKBP51: complex regulators of psychiatric diseases.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
373(1738)
[DOI] 10.1098/rstb.2016.0532.
[PMID] 29203717.
2018
Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD.
ACS chemical biology.
13(8):2288-2299
[DOI] 10.1021/acschembio.8b00454.
[PMID] 29893552.
2017
Hsp90 activator Aha1 drives production of pathological tau aggregates.
Proceedings of the National Academy of Sciences of the United States of America.
114(36):9707-9712
[DOI] 10.1073/pnas.1707039114.
[PMID] 28827321.
2017
Human cyclophilin 40 unravels neurotoxic amyloids.
PLoS biology.
15(6)
[DOI] 10.1371/journal.pbio.2001336.
[PMID] 28654636.
2012
Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.
The Journal of biological chemistry.
287(48):40661-9
[DOI] 10.1074/jbc.M112.384800.
[PMID] 23035116.
2011
Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathies.
Molecular neurobiology.
44(1):65-70
[DOI] 10.1007/s12035-011-8182-4.
[PMID] 21523562.
2011
Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics.
Current neuropharmacology.
9(4):623-31
[DOI] 10.2174/157015911798376226.
[PMID] 22654720.
2011
Neuronal life span versus health span: principles of natural selection at work in the degenerating brain.
Journal of molecular neuroscience : MN.
45(3):467-72
[DOI] 10.1007/s12031-011-9540-4.
[PMID] 21559875.
2011
The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau.
Journal of natural products.
74(1):38-44
[DOI] 10.1021/np100572z.
[PMID] 21141876.
2011
The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics.
The Journal of biological chemistry.
286(19):16976-83
[DOI] 10.1074/jbc.M110.182493.
[PMID] 21367866.
2010
Facilitating Akt clearance via manipulation of Hsp70 activity and levels.
The Journal of biological chemistry.
285(4):2498-505
[DOI] 10.1074/jbc.M109.057208.
[PMID] 19889640.
2010
Hsc70 rapidly engages tau after microtubule destabilization.
The Journal of biological chemistry.
285(22):16798-805
[DOI] 10.1074/jbc.M110.113753.
[PMID] 20308058.
2010
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden.
Molecular neurodegeneration.
5
[DOI] 10.1186/1750-1326-5-45.
[PMID] 21040568.
2010
Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
30(46):15374-82
[DOI] 10.1523/JNEUROSCI.3155-10.2010.
[PMID] 21084594.
2010
The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
30(2):591-9
[DOI] 10.1523/JNEUROSCI.4815-09.2010.
[PMID] 20071522.
2009
Chemical manipulation of hsp70 ATPase activity regulates tau stability.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
29(39):12079-88
[DOI] 10.1523/JNEUROSCI.3345-09.2009.
[PMID] 19793966.
Contact Details
Phones:
- Business:
- (352) 273-7538
Emails:
- Business:
- jkoren@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100244
GAINESVILLE FL 32610