Habibeh Khoshbouei

Habibeh Khoshbouei,

Professor

Department: Department of Neuroscience
Business Phone: (352) 273-8115
Business Email: habibeh@ufl.edu

Teaching Profile

Courses Taught
2012-2016,2018-2023
GMS6029 Brain Journal Club
2014-2025
GMS6023 Molecular Neuroscience and Neuropharmacology
2018,2022-2025
GMS7979 Advanced Research
2018,2022-2025
GMS7980 Research for Doctoral Dissertation
2017-2018
EGN4912 Engineering Directed Independent Research
2014-2018
GMS7794 Neuroscience Seminar
2013
GMS7795 Special Topics in Neuroscience
2022-2025
BMS4905 Medical Sciences Senior Research
2023-2025
GMS6792 Neuroscience Graduate Research Seminar

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-1533-8771

Publications

2024
Aurora kinase A inhibition plus Tumor Treating Fields suppress glioma cell proliferation in a cilium-independent manner
Translational Oncology. 45 [DOI] 10.1016/j.tranon.2024.101956. [PMID] 38640786.
2024
Development of a Fluorescently Labeled Ligand for Rapid Detection of DAT in Human and Mouse Peripheral Blood Monocytes.
JACS Au. 4(2):657-665 [DOI] 10.1021/jacsau.3c00719. [PMID] 38425927.
2024
Immunity on ice: The impact of methamphetamine on peripheral immunity
Pharmacological Advances in Central Nervous System Stimulants. 217-250 [DOI] 10.1016/bs.apha.2023.09.003.
2024
Immunophenotyping Tracks Motor Progression in Parkinson’s Disease Associated with a TH Mutation.
Journal of Parkinson's disease. 14(4):883-888 [DOI] 10.3233/JPD-240030. [PMID] 38788089.
2023
Asymmetric control of food intake by left and right vagal sensory neurons.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.05.08.539627. [PMID] 37214924.
2023
Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1.
Brain : a journal of neurology. 146(10):4217-4232 [DOI] 10.1093/brain/awad148. [PMID] 37143315.
2023
Clinical and pathological characterization of Central Nervous System cryptococcosis in an experimental mouse model of stereotaxic intracerebral infection.
PLoS neglected tropical diseases. 17(1) [DOI] 10.1371/journal.pntd.0011068. [PMID] 36656900.
2023
Complement C1q-dependent engulfment of alpha-synuclein induces ENS-resident macrophage exhaustion and accelerates Parkinson’s-like gut pathology.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.10.24.563832. [PMID] 37961460.
2023
Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine physiology in VPS35 p.D620N knock-in mice
npj Parkinson's Disease. 9(1) [DOI] 10.1038/s41531-023-00609-7. [PMID] 38110354.
2023
Methamphetamine induces a low dopamine transporter expressing state without altering the total number of peripheral immune cells.
Basic & clinical pharmacology & toxicology. 133(5):496-507 [DOI] 10.1111/bcpt.13838. [PMID] 36710070.
2023
Receptor-interacting protein kinase 2 (RIPK2) profoundly contributes to post-stroke neuroinflammation and behavioral deficits with microglia as unique perpetrators.
Journal of neuroinflammation. 20(1) [DOI] 10.1186/s12974-023-02907-6. [PMID] 37777791.
2023
Role of Microglia in Psychostimulant Addiction.
Current neuropharmacology. 21(2):235-259 [DOI] 10.2174/1570159X21666221208142151. [PMID] 36503452.
2023
The complex role of inflammation and gliotransmitters in Parkinson’s disease.
Neurobiology of disease. 176 [DOI] 10.1016/j.nbd.2022.105940. [PMID] 36470499.
2023
Who Knew? Dopamine Transporter Activity Is Critical in Innate and Adaptive Immune Responses
Cells. 12(2) [DOI] 10.3390/cells12020269. [PMID] 36672204.
2022
Cellular micromasonry: biofabrication with single cell precision
Soft Matter. 18(45):8554-8560 [DOI] 10.1039/d2sm01013e.
2022
DAT and TH expression marks human Parkinson’s disease in peripheral immune cells
npj Parkinson's Disease. 8(1) [DOI] 10.1038/s41531-022-00333-8. [PMID] 35672374.
2022
Dopamine and norepinephrine are embracing their immune side and so should we.
Current opinion in neurobiology. 77 [DOI] 10.1016/j.conb.2022.102626. [PMID] 36058009.
2022
Droplet Degeneration of Hippocampal and Cortical Neurons Signifies the Beginning of Neuritic Plaque Formation.
Journal of Alzheimer's disease : JAD. 85(4):1701-1720 [DOI] 10.3233/JAD-215334. [PMID] 34958037.
2022
Functional characterization of the biogenic amine transporters on human macrophages
JCI Insight. 7(4) [DOI] 10.1172/jci.insight.151892. [PMID] 35015729.
2022
Levodopa-induced dyskinesia: a historical review of Parkinson’s disease, dopamine, and modern advancements in research and treatment
Journal of Neurology. 269(6):2892-2909 [DOI] 10.1007/s00415-022-10963-w. [PMID] 35039902.
2022
Tumor Treating Fields Suppression of Ciliogenesis Enhances Temozolomide Toxicity.
Frontiers in oncology. 12 [DOI] 10.3389/fonc.2022.837589. [PMID] 35359402.
2021
Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure.
Scientific reports. 11(1) [DOI] 10.1038/s41598-020-80917-7. [PMID] 33446840.
2021
Author Correction: TNFα increases tyrosine hydroxylase expression in human monocytes
npj Parkinson's Disease. 7(1) [DOI] 10.1038/s41531-021-00212-8. [PMID] 34341346.
2021
Dopamine Transporter Is a Master Regulator of Dopaminergic Neural Network Connectivity
The Journal of Neuroscience. 41(25):5453-5470 [DOI] 10.1523/jneurosci.0223-21.2021.
2021
Dynamic control of the dopamine transporter in neurotransmission and homeostasis
npj Parkinson's Disease. 7(1) [DOI] 10.1038/s41531-021-00161-2. [PMID] 33674612.
2021
HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells
Cancers. 13(7) [DOI] 10.3390/cancers13071644. [PMID] 33915983.
2021
Identification of Critical Residues in the Carboxy Terminus of the Dopamine Transporter Involved in the G Protein βγ-Induced Dopamine Efflux.
Frontiers in pharmacology. 12 [DOI] 10.3389/fphar.2021.642881. [PMID] 33841159.
2021
In Parkinson’s patient-derived dopamine neurons, the triplication of α-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition
Acta Neuropathologica Communications. 9(1) [DOI] 10.1186/s40478-021-01203-9. [PMID] 34099060.
2021
Methamphetamine Dysregulation of the Central Nervous System and Peripheral Immunity.
The Journal of pharmacology and experimental therapeutics. 379(3):372-385 [DOI] 10.1124/jpet.121.000767. [PMID] 34535563.
2021
Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes.
Diabetes. 70(8):1885-1897 [DOI] 10.2337/db21-0070. [PMID] 34035041.
2021
The Role of Microglia in Sporadic Alzheimer’s Disease.
Journal of Alzheimer's disease : JAD. 79(3):961-968 [DOI] 10.3233/JAD-201248. [PMID] 33361603.
2021
TNFα increases tyrosine hydroxylase expression in human monocytes
npj Parkinson's Disease. 7(1) [DOI] 10.1038/s41531-021-00201-x. [PMID] 34285243.
2021
α-Synuclein-induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability
npj Parkinson's Disease. 7(1) [DOI] 10.1038/s41531-021-00210-w. [PMID] 34408150.
2020
A novel approach to study markers of dopamine signaling in peripheral immune cells.
Journal of immunological methods. 476 [DOI] 10.1016/j.jim.2019.112686. [PMID] 31634479.
2020
Allosterically Potentiated α7 Nicotinic Acetylcholine Receptors: Reduced Calcium Permeability and Current-Independent Control of Intracellular Calcium.
Molecular pharmacology. 98(6):695-709 [DOI] 10.1124/molpharm.120.000012. [PMID] 33020143.
2020
Alterations of the gut microbiota with antibiotics protects dopamine neuron loss and improve motor deficits in a pharmacological rodent model of Parkinson’s disease.
Experimental neurology. 325 [DOI] 10.1016/j.expneurol.2019.113159. [PMID] 31843492.
2020
Dystrophic microglia in late‐onset Alzheimer’s disease
Glia. 68(4):845-854 [DOI] 10.1002/glia.23782.
2020
Heterogeneity of dopamine release sites in health and degeneration
Neurobiology of Disease. 134 [DOI] 10.1016/j.nbd.2019.104633. [PMID] 31698055.
2020
Mechanism of Manganese Dysregulation of Dopamine Neuronal Activity
The Journal of Neuroscience. 40(30):5871-5891 [DOI] 10.1523/jneurosci.2830-19.2020.
2020
Microglia and Other Myeloid Cells in Central Nervous System Health and Disease.
The Journal of pharmacology and experimental therapeutics. 375(1):154-160 [DOI] 10.1124/jpet.120.265058. [PMID] 32238454.
2020
Microglia senescence occurs in both substantia nigra and ventral tegmental area
Glia. 68(11):2228-2245 [DOI] 10.1002/glia.23834. [PMID] 32275335.
2019
Clustered Kv2.1 decreases dopamine transporter activity and internalization.
The Journal of biological chemistry. 294(17):6957-6971 [DOI] 10.1074/jbc.RA119.007441. [PMID] 30824538.
2019
Dopamine increases HIV entry into macrophages by increasing calcium release via an alternative signaling pathway.
Brain, behavior, and immunity. 82:239-252 [DOI] 10.1016/j.bbi.2019.08.191. [PMID] 31470080.
2019
Elevated bone marrow sympathetic drive precedes systemic inflammation in angiotensin II hypertension.
American journal of physiology. Heart and circulatory physiology. 317(2):H279-H289 [DOI] 10.1152/ajpheart.00510.2018. [PMID] 31150271.
2019
Methamphetamine regulation of activity and topology of ventral midbrain networks.
PloS one. 14(9) [DOI] 10.1371/journal.pone.0222957. [PMID] 31536584.
2019
PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux
The Journal of Neuroscience. 39(27):5404-5418 [DOI] 10.1523/jneurosci.2942-18.2019.
2018
Amphetamine Reverses Escalated Cocaine Intake via Restoration of Dopamine Transporter Conformation
The Journal of Neuroscience. 38(2):484-497 [DOI] 10.1523/jneurosci.2604-17.2017.
2018
Functional connectivity, behavioral and dopaminergic alterations 24 hours following acute exposure to synthetic bath salt drug methylenedioxypyrovalerone
Neuropharmacology. 137:178-193 [DOI] 10.1016/j.neuropharm.2018.04.031. [PMID] 29729891.
2018
Glial cells modulate hippocampal synaptic plasticity in morphine dependent rats
Brain Research Bulletin. 140:97-106 [DOI] 10.1016/j.brainresbull.2018.04.006.
2018
Hippocampal glial cells modulate morphine-induced behavioral responses.
Physiology & behavior. 191:37-46 [DOI] 10.1016/j.physbeh.2018.04.003. [PMID] 29626506.
2018
HIV-1 Tat regulation of dopamine transmission and microglial reactivity is brain region specific.
Glia. 66(9):1915-1928 [DOI] 10.1002/glia.23447. [PMID] 29733459.
2018
Methamphetamine neurotoxicity, microglia, and neuroinflammation.
Journal of neuroinflammation. 15(1) [DOI] 10.1186/s12974-018-1385-0. [PMID] 30541633.
2018
Microglial activation occurs late during preclinical Alzheimer’s disease.
Glia. 66(12):2550-2562 [DOI] 10.1002/glia.23510. [PMID] 30417428.
2018
Prolonged increase in ser31 tyrosine hydroxylase phosphorylation in substantia nigra following cessation of chronic methamphetamine.
Neurotoxicology. 67:121-128 [DOI] 10.1016/j.neuro.2018.05.003. [PMID] 29782882.
2018
The dopamine transporter: An unrecognized nexus for dysfunctional peripheral immunity and signaling in Parkinson’s Disease.
Brain, behavior, and immunity. 70:21-35 [DOI] 10.1016/j.bbi.2018.03.020. [PMID] 29551693.
2018
The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction.
Pharmacology & therapeutics. 186:152-167 [DOI] 10.1016/j.pharmthera.2018.01.009. [PMID] 29360540.
2017
A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking.
PloS one. 12(5) [DOI] 10.1371/journal.pone.0173565. [PMID] 28467418.
2017
Alpha-synuclein modulates dopamine neurotransmission
Journal of Chemical Neuroanatomy. 83-84:41-49 [DOI] 10.1016/j.jchemneu.2016.06.001. [PMID] 27334403.
2017
HIV, Tat and dopamine transmission.
Neurobiology of disease. 105:51-73 [DOI] 10.1016/j.nbd.2017.04.015. [PMID] 28457951.
2017
Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology.
Journal of neurochemistry. 140(4):662-678 [DOI] 10.1111/jnc.13743. [PMID] 27424880.
2017
The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission.
Nature communications. 8(1) [DOI] 10.1038/s41467-017-02087-x. [PMID] 29263318.
2016
Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane.
Nature communications. 7 [DOI] 10.1038/ncomms10423. [PMID] 26804245.
2016
Methamphetamine Regulation of Firing Activity of Dopamine Neurons
The Journal of Neuroscience. 36(40):10376-10391 [DOI] 10.1523/jneurosci.1392-16.2016.
2016
Methamphetamine-induced enhancement of hippocampal long-term potentiation is modulated by NMDA and GABA receptors in the shell-accumbens.
Synapse (New York, N.Y.). 70(8):325-35 [DOI] 10.1002/syn.21905. [PMID] 27029021.
2016
The effects of GABAA and NMDA receptors in the shell-accumbens on spatial memory of METH-treated rats.
Pharmacology, biochemistry, and behavior. 142:23-35 [DOI] 10.1016/j.pbb.2015.12.008. [PMID] 26708956.
2015
Dopamine Transporter Activity Is Modulated by α-Synuclein.
The Journal of biological chemistry. 290(49):29542-54 [DOI] 10.1074/jbc.M115.691592. [PMID] 26442590.
2015
Dopamine Transporter Activity Is Modulated by α-synuclein.
The Journal of biological chemistry. [DOI] 10.1074/jbc.M115.639880. [PMID] 26048988.
2014
Chronic Methamphetamine Increases Alpha-Synuclein Protein Levels in the Striatum and Hippocampus but not in the Cortex of Juvenile Mice.
Journal of addiction & prevention. 2(2) [PMID] 25621291.
2014
Intracellular methamphetamine prevents the dopamine-induced enhancement of neuronal firing.
The Journal of biological chemistry. 289(32):22246-57 [DOI] 10.1074/jbc.M114.563056. [PMID] 24962577.
2013
Chronic methamphetamine exposure produces a delayed, long-lasting memory deficit.
Synapse (New York, N.Y.). 67(5):245-57 [DOI] 10.1002/syn.21635. [PMID] 23280858.
2013
The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells.
Neurotoxicology. 35:121-8 [DOI] 10.1016/j.neuro.2013.01.002. [PMID] 23313730.
2012
PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene.
Toxicological sciences : an official journal of the Society of Toxicology. 125(1):233-47 [DOI] 10.1093/toxsci/kfr261. [PMID] 21987461.
2012
Single cell measurement of dopamine release with simultaneous voltage-clamp and amperometry.
Journal of visualized experiments : JoVE. (69) [DOI] 10.3791/3798. [PMID] 23207721.
2011
α-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter.
The Journal of biological chemistry. 286(51):43933-43943 [DOI] 10.1074/jbc.M111.241232. [PMID] 21990355.
2010
Methamphetamine reduces LTP and increases baseline synaptic transmission in the CA1 region of mouse hippocampus.
PloS one. 5(6) [DOI] 10.1371/journal.pone.0011382. [PMID] 20614033.
2009
Amphetamine and methamphetamine differentially affect dopamine transporters in vitro and in vivo.
The Journal of biological chemistry. 284(5):2978-2989 [DOI] 10.1074/jbc.M805298200. [PMID] 19047053.
2008
PI3K signaling supports amphetamine-induced dopamine efflux.
Biochemical and biophysical research communications. 372(4):656-61 [DOI] 10.1016/j.bbrc.2008.05.091. [PMID] 18510945.
2008
Prenatal exposure to benzo(a)pyrene impairs later-life cortical neuronal function.
Neurotoxicology. 29(5):846-54 [DOI] 10.1016/j.neuro.2008.07.008. [PMID] 18761371.
2006
Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport.
Neuron. 51(4):417-29 [PMID] 16908408.
2005
Amphetamine induces dopamine efflux through a dopamine transporter channel.
Proceedings of the National Academy of Sciences of the United States of America. 102(9):3495-500 [PMID] 15728379.
2004
Intracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter.
Molecular pharmacology. 66(1):137-43 [PMID] 15213305.
2004
N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux.
PLoS biology. 2(3) [PMID] 15024426.
2003
Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanism.
The Journal of biological chemistry. 278(14):12070-7 [PMID] 12556446.
2003
Interactions of norepinephrine and galanin in the central amygdala and lateral bed nucleus of the stria terminalis modulate the behavioral response to acute stress.
Life sciences. 73(6):715-26 [PMID] 12801593.
2002
Behavioral reactivity to stress: amplification of stress-induced noradrenergic activation elicits a galanin-mediated anxiolytic effect in central amygdala.
Pharmacology, biochemistry, and behavior. 71(3):407-17 [PMID] 11830175.
2002
Modulatory effects of galanin in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 27(1):25-34 [PMID] 12062904.
2002
Modulatory effects of norepinephrine in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress.
Neuroscience. 112(1):13-21 [PMID] 12044468.
2002
Modulatory effects of norepinephrine, acting on alpha 1 receptors in the central nucleus of the amygdala, on behavioral and neuroendocrine responses to acute immobilization stress.
Neuropharmacology. 43(7):1139-47 [PMID] 12504920.
1998
Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.
Journal of neurochemistry. 71(6):2239-51 [PMID] 9832121.

Grants

Aug 2023 ACTIVE
Vagus nerve stimulation increases basal dopamine levels in the brain to decrease methamphetamine-mediated responses
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
Jul 2023 ACTIVE
Defining molecular mechanisms by which stimulant evoked dopamine drives inflammation and neuronal dysfunction in neuroHIV
Role: Principal Investigator
Funding: DREXEL UNIVERSITY via NATL INST OF HLTH NIDA
Jul 2023 ACTIVE
The interactions between myenteric macrophages and enteric neurons shape development and spread of enteric synucleinopathy
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jun 2023 ACTIVE
Role of RIPK2 in the neuroinflammatory response to ischemic stroke
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
May 2023 ACTIVE
Investigating the role of myenteric macrophages in enteric synucleinopathy
Role: Other
Funding: NATL INST OF HLTH NINDS
Apr 2022 – Jun 2022
Reward Signaling in the Gut-Brain Axis
Role: Other
Funding: NATL INST OF HLTH NIDDK
Jun 2020 – May 2021
iPSCs-derived cortical neurons with Xq27-q28 deletion display altered morphology, transcriptomics, maturation and increased neuronal activity
Role: Principal Investigator
Funding: XTRAORDINARY JOY FOUNDATION
Dec 2019 – May 2024
LRRK2-Synuclein Interactions with Gut Inflammation in PD Pathogenesis
Role: Project Manager
Funding: PARKINSONS FOU
Sep 2018 ACTIVE
Alpha-synuclein Regulates Dopamine Transporter Functions
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Feb 2018 – Feb 2020
Role of Microglia in Primary Age Related Tauopathy and in Sporadic (late-onset) Alzheimer's Disease
Role: Principal Investigator
Funding: FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Dec 2017 – Nov 2019
Functional interplay between D2 autoreceptor and dopamine transporter
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jun 2017 – Jun 2018
Functional interaction between microglia and dopamine neurons
Role: Principal Investigator
Funding: INT BRAIN RES ORG
Mar 2017 – Feb 2019
Interactions between microglia and dopaminergic neurons regulates dopamine neurotransmission
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
Aug 2016 – Aug 2019
OR-DRPD-ROF2016: A Neurodevelopmental Theory of Social and Environmental Isolation in Autism
Role: Co-Investigator
Funding: UF RESEARCH
Jul 2016 – Jun 2023
The Human Thalamocortical Network in tourette syndrome
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2015 – Apr 2022
Methamphetamine regulates the dopamine transporter via an intracellular mechanism
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
Apr 2015 – Apr 2016
Shared Nikon A1R multiphoton laser scanning confocal system
Role: Principal Investigator
Funding: NATL INST OF HLTH OD
Nov 2011 – Apr 2016
Alpha-synuclein regulates dopamine transporter functions
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS

Contact Details

Phones:
Business:
(352) 273-8115
Emails:
Business:
habibeh@ufl.edu
Addresses:
Business Mailing:
1149 SOUTH NEWELL DRIVE, ROOM L1-100D,
PO BOX 100244
MCKNIGHT BRAIN INSTITUTE
GAINESVILLE FL 32610-0244
Business Street:
MCKNIGHT BRAIN INSTITUTE;1149 SOUTH NEWELL D
PO BOX 100244
UNIVESITY OF FLORIDA
GAINESVILLE FL 326100244