Thomas C Foster,
Professor, Evelyn F. McKnight Chair for Research on Cognitive Aging and Memory
Department:
Department of Neuroscience
Business Phone:
(352) 273-0033
Business Email:
foster1@ufl.edu
Teaching Profile
Courses Taught
2014-2019,2023
GMS6022 Principles of Neurophysiology
2018
GMS6052 Ion Channels of Excitable Membranes
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2018
BME7980 Research for Doctoral Dissertation
2013-2015
GMS6417 Integrative Aging Physiology
2015
GMS6063 Mechanisms of Aging
2015
GMS7794 Neuroscience Seminar
2007-2009
GMS6029 Brain Journal Club
2024-2025
GMS7795 Special Topics in Neuroscience
Publications
Academic Articles
2025
International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus.
GeroScience.
[DOI] 10.1007/s11357-025-01509-9.
[PMID] 39982667.
2025
Sex, senescence, senolytics, and cognition.
Frontiers in aging neuroscience.
17
[DOI] 10.3389/fnagi.2025.1555872.
[PMID] 40103928.
2024
Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2024.09.02.24312951.
[PMID] 39281746.
2024
Differential DNA methylation profiles of Alzheimer’s disease-related genomic pathways in the blood of cognitively-intact individuals with and without high impact chronic pain.
Journal of Alzheimer's disease reports.
8(1):1549-1557
[DOI] 10.1177/25424823241289376.
[PMID] 40034342.
2024
Failure of senolytic treatment to prevent cognitive decline in a female rodent model of aging.
Frontiers in aging neuroscience.
16
[DOI] 10.3389/fnagi.2024.1384554.
[PMID] 38813533.
2024
Senolytic treatment alleviates doxorubicin-induced chemobrain.
Aging cell.
23(2)
[DOI] 10.1111/acel.14037.
[PMID] 38225896.
2024
Socioeconomic Status, Knee Pain, and Epigenetic Aging in Community-Dwelling Middle-to-Older Age Adults.
The journal of pain.
25(2):293-301
[DOI] 10.1016/j.jpain.2023.06.002.
[PMID] 37315728.
2023
Animal models for studies of alcohol effects on the trajectory of age-related cognitive decline
Alcohol.
107:4-11
[DOI] 10.1016/j.alcohol.2022.04.005.
2023
Effect of peripheral cellular senescence on brain aging and cognitive decline.
Aging cell.
22(5)
[DOI] 10.1111/acel.13817.
[PMID] 36959691.
2023
Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain.
Social science & medicine (1982).
331
[DOI] 10.1016/j.socscimed.2023.116088.
[PMID] 37473540.
2023
Pain interference mediates the association between epigenetic aging and grip strength in middle to older aged males and females with chronic pain.
Frontiers in aging neuroscience.
15
[DOI] 10.3389/fnagi.2023.1122364.
[PMID] 37032822.
2023
Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection.
Clinical science (London, England : 1979).
137(12):963-978
[DOI] 10.1042/CS20220555.
[PMID] 37337946.
2023
Vitamin D Metabolism Genes Are Differentially Methylated in Individuals with Chronic Knee Pain.
Lifestyle genomics.
16(1):98-105
[DOI] 10.1159/000529823.
[PMID] 36854277.
2022
Accelerated Epigenetic Aging Mediates the Association between Vitamin D Levels and Knee Pain in Community-Dwelling Individuals.
The journal of nutrition, health & aging…
26(4):318-323
[DOI] 10.1007/s12603-022-1758-z.
[PMID] 35450986.
2022
Enrichment of genomic pathways based on differential DNA methylation profiles associated with knee osteoarthritis pain.
Neurobiology of pain (Cambridge, Mass.).
12
[DOI] 10.1016/j.ynpai.2022.100107.
[PMID] 36531611.
2022
Epigenetic age predictors in community-dwelling adults with high impact knee pain.
Molecular pain.
18
[DOI] 10.1177/17448069221118004.
[PMID] 35968561.
2022
Epigenetic Aging Mediates the Association between Pain Impact and Brain Aging in Middle to Older Age Individuals with Knee Pain.
Epigenetics.
17(13):2178-2187
[DOI] 10.1080/15592294.2022.2111752.
[PMID] 35950599.
2022
Epigenetic aging, knee pain and physical performance in community-dwelling middle-to-older age adults.
Experimental gerontology.
166
[DOI] 10.1016/j.exger.2022.111861.
[PMID] 35640781.
2022
Exosomes in Age-Related Cognitive Decline: Mechanistic Insights and Improving Outcomes.
Frontiers in aging neuroscience.
14
[DOI] 10.3389/fnagi.2022.834775.
[PMID] 35299946.
2022
Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis.
Aging.
14(2):728-746
[DOI] 10.18632/aging.203868.
[PMID] 35094981.
2022
Operationally defining cognitive reserve genes
Neurobiology of Aging.
110:96-105
[DOI] 10.1016/j.neurobiolaging.2021.08.015.
2022
Sex differences associate with late microbiome alterations after murine surgical sepsis.
The journal of trauma and acute care surgery.
93(2):137-146
[DOI] 10.1097/TA.0000000000003599.
[PMID] 35324554.
2021
Adulthood systemic inflammation accelerates the trajectory of age-related cognitive decline.
Aging.
13(18):22092-22108
[DOI] 10.18632/aging.203588.
[PMID] 34587117.
2021
Cellular senescence in lymphoid organs and immunosenescence.
Aging.
13(15):19920-19941
[DOI] 10.18632/aging.203405.
[PMID] 34382946.
2021
Chronic “sepsis brain” and regulatory T cells – A promising therapeutic target.
Brain, behavior, and immunity.
93:10-11
[DOI] 10.1016/j.bbi.2021.01.017.
[PMID] 33516922.
2021
Examination of CA1 Hippocampal DNA Methylation as a Mechanism for Closing of Estrogen’s Critical Window.
Frontiers in aging neuroscience.
13
[DOI] 10.3389/fnagi.2021.717032.
[PMID] 34421577.
2021
Partial microglial depletion is associated with impaired hippocampal synaptic and cognitive function in young and aged rats.
Glia.
69(6):1494-1514
[DOI] 10.1002/glia.23975.
[PMID] 33586813.
2021
Senescence-associated hyper-activation to inflammatory stimuli in vitro.
Aging.
13(15):19088-19107
[DOI] 10.18632/aging.203396.
[PMID] 34375950.
2020
Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies.
Frontiers in aging neuroscience.
12
[DOI] 10.3389/fnagi.2020.607685.
[PMID] 33551788.
2020
Differential Effect of Repeated Lipopolysaccharide Treatment and Aging on Hippocampal Function and Biomarkers of Hippocampal Senescence.
Molecular neurobiology.
57(10):4045-4059
[DOI] 10.1007/s12035-020-02008-y.
[PMID] 32651758.
2020
Enrichment of genomic pathways based on differential DNA methylation profiles associated with chronic musculoskeletal pain in older adults: An exploratory study.
Molecular pain.
16
[DOI] 10.1177/1744806920966902.
[PMID] 33073674.
2020
G Protein-Coupled Estrogen Receptor: Rapid Effects on Hippocampal-Dependent Spatial Memory and Synaptic Plasticity.
Frontiers in endocrinology.
11
[DOI] 10.3389/fendo.2020.00385.
[PMID] 32587576.
2020
Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
40(25):4888-4899
[DOI] 10.1523/JNEUROSCI.2944-19.2020.
[PMID] 32376783.
2020
Longitudinal Characterization and Biomarkers of Age and Sex Differences in the Decline of Spatial Memory.
Frontiers in aging neuroscience.
12
[DOI] 10.3389/fnagi.2020.00034.
[PMID] 32153384.
2020
Microglia senescence occurs in both substantia nigra and ventral tegmental area.
Glia.
68(11):2228-2245
[DOI] 10.1002/glia.23834.
[PMID] 32275335.
2020
MicroRNA predicts cognitive performance in healthy older adults.
Neurobiology of aging.
95:186-194
[DOI] 10.1016/j.neurobiolaging.2020.07.023.
[PMID] 32846274.
2019
Age and Sex Influence the Hippocampal Response and Recovery Following Sepsis.
Molecular neurobiology.
56(12):8557-8572
[DOI] 10.1007/s12035-019-01681-y.
[PMID] 31278440.
2019
Alteration in NMDA Receptor Mediated Glutamatergic Neurotransmission in the Hippocampus During Senescence.
Neurochemical research.
44(1):38-48
[DOI] 10.1007/s11064-018-2634-4.
[PMID] 30209673.
2019
Animal models of cognitive aging and circuit-specific vulnerability.
Handbook of clinical neurology.
167:19-36
[DOI] 10.1016/B978-0-12-804766-8.00002-9.
[PMID] 31753133.
2019
Behavior Model for Assessing Decline in Executive Function During Aging and Neurodegenerative Diseases.
Methods in molecular biology (Clifton, N.J.).
2011:441-449
[DOI] 10.1007/978-1-4939-9554-7_26.
[PMID] 31273715.
2019
Effect of Systemic Inflammation on Rat Attentional Function and Neuroinflammation: Possible Protective Role for Food Restriction.
Frontiers in aging neuroscience.
11
[DOI] 10.3389/fnagi.2019.00296.
[PMID] 31708767.
2019
Enhancement of BDNF Expression and Memory by HDAC Inhibition Requires BET Bromodomain Reader Proteins.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
39(4):612-626
[DOI] 10.1523/JNEUROSCI.1604-18.2018.
[PMID] 30504275.
2019
Epigenetic aging is associated with clinical and experimental pain in community-dwelling older adults.
Molecular pain.
15
[DOI] 10.1177/1744806919871819.
[PMID] 31394966.
2019
GSTA4 mediates reduction of cisplatin ototoxicity in female mice.
Nature communications.
10(1)
[DOI] 10.1038/s41467-019-12073-0.
[PMID] 31515474.
2019
How do we validate approaches that aim to harness reserve to improve the aging brain?
Neurobiology of aging.
83:145-149
[DOI] 10.1016/j.neurobiolaging.2019.03.024.
[PMID] 31732018.
2019
HSP90 Inhibitor, NVP-AUY922, Improves Myelination in Vitro and Supports the Maintenance of Myelinated Axons in Neuropathic Mice.
ACS chemical neuroscience.
10(6):2890-2902
[DOI] 10.1021/acschemneuro.9b00105.
[PMID] 31017387.
2019
Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.
Critical care medicine.
47(11):e919-e929
[DOI] 10.1097/CCM.0000000000003926.
[PMID] 31389840.
2019
Senescent neurophysiology: Ca2+ signaling from the membrane to the nucleus.
Neurobiology of learning and memory.
164
[DOI] 10.1016/j.nlm.2019.107064.
[PMID] 31394200.
2019
Subunit contribution to NMDA receptor hypofunction and redox sensitivity of hippocampal synaptic transmission during aging.
Aging.
11(14):5140-5157
[DOI] 10.18632/aging.102108.
[PMID] 31339863.
2018
Aging in the Brain: New Roles of Epigenetics in Cognitive Decline.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.
24(5):516-525
[DOI] 10.1177/1073858418780971.
[PMID] 29877135.
2018
Nonsteroidal anti-inflammatory drug, indomethacin improves spatial memory and NMDA receptor function in aged animals.
Neurobiology of aging.
70:184-193
[DOI] 10.1016/j.neurobiolaging.2018.06.026.
[PMID] 30031231.
2018
Redox Signaling in Neurotransmission and Cognition During Aging.
Antioxidants & redox signaling.
28(18):1724-1745
[DOI] 10.1089/ars.2017.7111.
[PMID] 28467718.
2017
Central role for NMDA receptors in redox mediated impairment of synaptic function during aging and Alzheimer’s disease.
Behavioural brain research.
322(Pt B):223-232
[DOI] 10.1016/j.bbr.2016.05.012.
[PMID] 27180169.
2017
DNA Methylation of Synaptic Genes in the Prefrontal Cortex Is Associated with Aging and Age-Related Cognitive Impairment.
Frontiers in aging neuroscience.
9
[DOI] 10.3389/fnagi.2017.00249.
[PMID] 28824413.
2017
Epigenetic regulation of estrogen receptor α contributes to age-related differences in transcription across the hippocampal regions CA1 and CA3.
Neurobiology of aging.
49:79-85
[DOI] 10.1016/j.neurobiolaging.2016.09.013.
[PMID] 27776265.
2017
Hippocampal Transcriptomic Profiles: Subfield Vulnerability to Age and Cognitive Impairment.
Frontiers in aging neuroscience.
9
[DOI] 10.3389/fnagi.2017.00383.
[PMID] 29276487.
2017
Indomethacin Increases Neurogenesis across Age Groups and Improves Delayed Probe Trial Difference Scores in Middle-Aged Rats.
Frontiers in aging neuroscience.
9
[DOI] 10.3389/fnagi.2017.00280.
[PMID] 28928652.
2017
miRNA in Circulating Microvesicles as Biomarkers for Age-Related Cognitive Decline.
Frontiers in aging neuroscience.
9
[DOI] 10.3389/fnagi.2017.00323.
[PMID] 29046635.
2016
Increased N-Ethylmaleimide-Sensitive Factor Expression in Amygdala and Perirhinal Cortex during Habituation of Taste Neophobia.
Neural plasticity.
2016
[DOI] 10.1155/2016/2726745.
[PMID] 26839712.
2016
Preclinical Magnetic Resonance Imaging and Spectroscopy Studies of Memory, Aging, and Cognitive Decline.
Frontiers in aging neuroscience.
8
[DOI] 10.3389/fnagi.2016.00158.
[PMID] 27468264.
2016
Transcription Profile of Aging and Cognition-Related Genes in the Medial Prefrontal Cortex.
Frontiers in aging neuroscience.
8
[DOI] 10.3389/fnagi.2016.00113.
[PMID] 27242522.
2016
Type 3 Adenylyl Cyclase and Somatostatin Receptor 3 Expression Persists in Aged Rat Neocortical and Hippocampal Neuronal Cilia.
Frontiers in aging neuroscience.
8
[DOI] 10.3389/fnagi.2016.00127.
[PMID] 27303293.
2015
Contribution of estrogen receptor subtypes, ERα, ERβ, and GPER1 in rapid estradiol-mediated enhancement of hippocampal synaptic transmission in mice.
Hippocampus.
25(12):1556-66
[DOI] 10.1002/hipo.22475.
[PMID] 25980457.
2015
Contribution of N-methyl-D-aspartate receptors to attention and episodic spatial memory during senescence.
Neurobiology of learning and memory.
125:36-46
[DOI] 10.1016/j.nlm.2015.07.015.
[PMID] 26234588.
2015
Impaired attention and synaptic senescence of the prefrontal cortex involves redox regulation of NMDA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
35(9):3966-77
[DOI] 10.1523/JNEUROSCI.3523-14.2015.
[PMID] 25740525.
2015
Re-Opening the Critical Window for Estrogen Therapy.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
35(49):16077-93
[DOI] 10.1523/JNEUROSCI.1890-15.2015.
[PMID] 26658861.
2015
Role of estrogen receptor-α on food demand elasticity.
Journal of the experimental analysis of behavior.
103(3):553-61
[DOI] 10.1002/jeab.149.
[PMID] 25869426.
2015
Some hormone, cytokine and chemokine levels that change across lifespan vary by cognitive status in male Fischer 344 rats.
Brain, behavior, and immunity.
49:216-32
[DOI] 10.1016/j.bbi.2015.06.005.
[PMID] 26093306.
2015
Successful aging: Advancing the science of physical independence in older adults.
Ageing research reviews.
24(Pt B):304-27
[DOI] 10.1016/j.arr.2015.09.005.
[PMID] 26462882.
2014
Assessing the emergence and reliability of cognitive decline over the life span in Fisher 344 rats using the spatial water maze.
Frontiers in aging neuroscience.
6
[DOI] 10.3389/fnagi.2014.00002.
[PMID] 24478698.
2014
Estrogen receptors, the hippocampus, and memory.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.
20(5):534-45
[DOI] 10.1177/1073858413519865.
[PMID] 24510074.
2014
Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses.
Hippocampus.
24(4):466-75
[DOI] 10.1002/hipo.22240.
[PMID] 24390964.
2014
Role of antioxidant enzymes in redox regulation of N-methyl-D-aspartate receptor function and memory in middle-aged rats.
Neurobiology of aging.
35(6):1459-68
[DOI] 10.1016/j.neurobiolaging.2013.12.002.
[PMID] 24388786.
2013
AAV-mediated gene therapy in the guanylate cyclase (RetGC1/RetGC2) double knockout mouse model of Leber congenital amaurosis.
Human gene therapy.
24(2):189-202
[DOI] 10.1089/hum.2012.193.
[PMID] 23210611.
2013
Daily exercise improves memory, stimulates hippocampal neurogenesis and modulates immune and neuroimmune cytokines in aging rats.
Brain, behavior, and immunity.
28:25-43
[DOI] 10.1016/j.bbi.2012.09.013.
[PMID] 23078985.
2013
Environmental enrichment restores neurogenesis and rapid acquisition in aged rats.
Neurobiology of aging.
34(1):263-74
[DOI] 10.1016/j.neurobiolaging.2012.05.023.
[PMID] 22795793.
2013
Linking redox regulation of NMDAR synaptic function to cognitive decline during aging.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
33(40):15710-5
[DOI] 10.1523/JNEUROSCI.2176-13.2013.
[PMID] 24089479.
2013
Memory in aged mice is rescued by enhanced expression of the GluN2B subunit of the NMDA receptor.
Behavioural brain research.
238:211-26
[DOI] 10.1016/j.bbr.2012.10.026.
[PMID] 23103326.
2013
Role of estrogen receptor α and β in preserving hippocampal function during aging.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
33(6):2671-83
[DOI] 10.1523/JNEUROSCI.4937-12.2013.
[PMID] 23392694.
2012
Behavioral model for assessing cognitive decline.
Methods in molecular biology (Clifton, N.J.).
829:145-53
[DOI] 10.1007/978-1-61779-458-2_8.
[PMID] 22231811.
2012
Challenges and opportunities for characterizing cognitive aging across species.
Frontiers in aging neuroscience.
4
[DOI] 10.3389/fnagi.2012.00006.
[PMID] 22988434.
2012
Challenges and opportunities in characterizing cognitive aging across species.
Frontiers in aging neuroscience.
4
[DOI] 10.3389/fnagi.2012.00033.
[PMID] 23189053.
2012
Characterizing cognitive aging in humans with links to animal models.
Frontiers in aging neuroscience.
4
[DOI] 10.3389/fnagi.2012.00021.
[PMID] 22988439.
2012
Characterizing cognitive aging of spatial and contextual memory in animal models.
Frontiers in aging neuroscience.
4
[DOI] 10.3389/fnagi.2012.00012.
[PMID] 22988436.
2012
Characterizing cognitive aging of working memory and executive function in animal models.
Frontiers in aging neuroscience.
4
[DOI] 10.3389/fnagi.2012.00019.
[PMID] 22988438.
2012
Dissecting the age-related decline on spatial learning and memory tasks in rodent models: N-methyl-D-aspartate receptors and voltage-dependent Ca2+ channels in senescent synaptic plasticity.
Progress in neurobiology.
96(3):283-303
[DOI] 10.1016/j.pneurobio.2012.01.007.
[PMID] 22307057.
2012
Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology.
Neurobiology of learning and memory.
97(1):69-80
[DOI] 10.1016/j.nlm.2011.09.006.
[PMID] 21982980.
2012
Increasing hippocampal estrogen receptor alpha levels via viral vectors increases MAP kinase activation and enhances memory in aging rats in the absence of ovarian estrogens.
PloS one.
7(12)
[DOI] 10.1371/journal.pone.0051385.
[PMID] 23240018.
2012
Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology.
Neurobiology of aging.
33(4):828.e1-17
[DOI] 10.1016/j.neurobiolaging.2011.06.023.
[PMID] 21820213.
2012
Influence of viral vector-mediated delivery of superoxide dismutase and catalase to the hippocampus on spatial learning and memory during aging.
Antioxidants & redox signaling.
16(4):339-50
[DOI] 10.1089/ars.2011.4054.
[PMID] 21942371.
2012
Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy.
Neuron.
75(3):437-50
[DOI] 10.1016/j.neuron.2012.05.029.
[PMID] 22884328.
2012
Role of estrogen receptor alpha and beta expression and signaling on cognitive function during aging.
Hippocampus.
22(4):656-69
[DOI] 10.1002/hipo.20935.
[PMID] 21538657.
2012
Session III: Mechanisms of age-related cognitive change and targets for intervention: inflammatory, oxidative, and metabolic processes.
The journals of gerontology. Series A, Biological sciences and medical sciences.
67(7):754-9
[DOI] 10.1093/gerona/gls112.
[PMID] 22570133.
2012
Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia.
The journals of gerontology. Series A, Biological sciences and medical sciences.
67(1):17-27
[DOI] 10.1093/gerona/glr042.
[PMID] 21636833.
2011
Altered behavior in experimental cortical dysplasia.
Epilepsia.
52(12):2293-303
[DOI] 10.1111/j.1528-1167.2011.03267.x.
[PMID] 21933180.
2011
Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 × Brown Norway rats.
Age (Dordrecht, Netherlands).
33(2):167-83
[DOI] 10.1007/s11357-010-9196-y.
[PMID] 21153712.
2011
Gene expression in the hippocampus: regionally specific effects of aging and caloric restriction.
Mechanisms of ageing and development.
132(1-2):8-19
[DOI] 10.1016/j.mad.2010.10.006.
[PMID] 21055414.
2011
Lifelong caloric restriction prevents age-induced oxidative stress in the sympathoadrenal system of Fischer 344 x Brown Norway rats.
Biochemical and biophysical research communications.
408(3):454-8
[DOI] 10.1016/j.bbrc.2011.04.051.
[PMID] 21527245.
2010
Aging alters the expression of genes for neuroprotection and synaptic function following acute estradiol treatment.
Hippocampus.
20(9):1047-60
[DOI] 10.1002/hipo.20703.
[PMID] 19790252.
2010
Intracellular redox state alters NMDA receptor response during aging through Ca2+/calmodulin-dependent protein kinase II.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
30(5):1914-24
[DOI] 10.1523/JNEUROSCI.5485-09.2010.
[PMID] 20130200.
2010
PHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus.
Journal of neurochemistry.
115(4):941-55
[DOI] 10.1111/j.1471-4159.2010.06984.x.
[PMID] 20819118.
2010
Redox sensitive calcium stores underlie enhanced after hyperpolarization of aged neurons: role for ryanodine receptor mediated calcium signaling.
Journal of neurophysiology.
104(5):2586-93
[DOI] 10.1152/jn.00577.2010.
[PMID] 20884759.
2009
Comparison of lifelong and late life exercise on oxidative stress in the cerebellum.
Neurobiology of aging.
30(6):903-9
[PMID] 17976863.
2009
Estrogen effects on cognition and hippocampal transcription in middle-aged mice.
Neurobiology of aging.
30(6):932-45
[PMID] 17950954.
2009
Fragile X mental retardation protein replacement restores hippocampal synaptic function in a mouse model of fragile X syndrome.
Gene therapy.
16(9):1122-9
[DOI] 10.1038/gt.2009.83.
[PMID] 19571888.
2009
Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity.
The journals of gerontology. Series A, Biological sciences and medical sciences.
64(8):850-9
[DOI] 10.1093/gerona/glp060.
[PMID] 19420296.
2009
Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot-Marie-Tooth disease.
Neurobiology of disease.
34(1):146-54
[PMID] 19320048.
2009
Regional Health and Function in the hippocampus: Evolutionary compromises for a critical brain region.
Bioscience hypotheses.
2(4):245-251
[PMID] 20161206.
2009
Regional hippocampal differences in AKT survival signaling across the lifespan: implications for CA1 vulnerability with aging.
Cell death and differentiation.
16(3):439-48
[DOI] 10.1038/cdd.2008.171.
[PMID] 19039330.
2009
Susceptibility to Calcium Dysregulation during Brain Aging.
Frontiers in aging neuroscience.
1
[DOI] 10.3389/neuro.24.002.2009.
[PMID] 20552053.
2008
AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation.
Investigative ophthalmology & visual science.
49(10):4278-83
[DOI] 10.1167/iovs.07-1622.
[PMID] 18586879.
2008
Viral vector-mediated delivery of estrogen receptor-alpha to the hippocampus improves spatial learning in estrogen receptor-alpha knockout mice.
Molecular therapy : the journal of the American Society of Gene Therapy.
16(9):1587-93
[DOI] 10.1038/mt.2008.140.
[PMID] 18594506.
2007
Aging effects on the limits and stability of long-term synaptic potentiation and depression in rat hippocampal area CA1.
Journal of neurophysiology.
98(2):594-601
[PMID] 17553951.
2007
Calcium homeostasis and modulation of synaptic plasticity in the aged brain.
Aging cell.
6(3):319-25
[PMID] 17517041.
2007
Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats.
Brain research.
1162:9-18
[PMID] 17617388.
2007
Environmental enrichment decreases the afterhyperpolarization in senescent rats.
Brain research.
1130(1):103-7
[PMID] 17169341.
2007
Shift in induction mechanisms underlies an age-dependent increase in DHPG-induced synaptic depression at CA3 CA1 synapses.
Journal of neurophysiology.
98(5):2729-36
[PMID] 17898145.
2007
Susceptibility to induction of long-term depression is associated with impaired memory in aged Fischer 344 rats.
Neurobiology of learning and memory.
87(4):522-35
[PMID] 17276704.
2006
Biological markers of age-related memory deficits: treatment of senescent physiology.
CNS drugs.
20(2):153-66
[PMID] 16478290.
2006
Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis.
Molecular therapy : the journal of the American Society of Gene Therapy.
13(3):565-72
[PMID] 16223604.
2005
Interaction of rapid signal transduction cascades and gene expression in mediating estrogen effects on memory over the life span.
Frontiers in neuroendocrinology.
26(2):51-64
[PMID] 16023185.
2005
Intracellular calcium stores contribute to increased susceptibility to LTD induction during aging.
Brain research.
1031(1):125-8
[PMID] 15621020.
2005
Prodynorphin knockout mice demonstrate diminished age-associated impairment in spatial water maze performance.
Behavioural brain research.
161(2):254-62
[PMID] 15922052.
2004
Enhanced long-term potentiation during aging is masked by processes involving intracellular calcium stores.
Journal of neurophysiology.
91(6):2437-44
[PMID] 14762159.
2003
Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
23(9):3807-19
[PMID] 12736351.
2003
Interaction of age and chronic estradiol replacement on memory and markers of brain aging.
Neurobiology of aging.
24(6):839-52
[PMID] 12927766.
2003
The neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-D-aspartate receptors.
Alcoholism, clinical and experimental research.
27(11):1724-35
[PMID] 14634487.
2002
17beta-estradiol benzoate decreases the AHP amplitude in CA1 pyramidal neurons.
Journal of neurophysiology.
88(2):621-6
[PMID] 12163515.
2002
Calcineurin as a potential contributor in estradiol regulation of hippocampal synaptic function.
Neuroscience.
113(1):89-97
[PMID] 12123687.
2002
Calcium dysregulation in the aging brain.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.
8(4):297-301
[PMID] 12194497.
2002
Regulation of synaptic plasticity in memory and memory decline with aging.
Progress in brain research.
138:283-303
[PMID] 12432775.
2001
Calcineurin links Ca2+ dysregulation with brain aging.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
21(11):4066-73
[PMID] 11356894.
2001
Examination of estradiol effects on the rapid estradiol mediated increase in hippocampal synaptic transmission in estrogen receptor alpha knockout mice.
Neuroscience letters.
309(3):207-9
[PMID] 11514077.
2001
Mechanism for increased hippocampal synaptic strength following differential experience.
Journal of neurophysiology.
85(4):1377-83
[PMID] 11287462.
2000
Novel effects of estradiol and estrogen receptor alpha and beta on cognitive function.
Brain research.
883(2):258-64
[PMID] 11074057.
2000
Receptor blockade reveals a correspondence between hippocampal-dependent behavior and experience-dependent synaptic enhancement.
Brain research.
871(1):39-43
[PMID] 10882780.
1999
Involvement of hippocampal synaptic plasticity in age-related memory decline.
Brain research. Brain research reviews.
30(3):236-49
[PMID] 10567726.
1999
MK-801 improves retention in aged rats: implications for altered neural plasticity in age-related memory deficits.
Neurobiology of learning and memory.
71(2):194-206
[PMID] 10082639.
1999
Sex with knockout models: behavioral studies of estrogen receptor alpha.
Brain research.
835(1):80-90
[PMID] 10448199.
1998
Alterations in the balance of protein kinase/phosphatase activities parallel reduced synaptic strength during aging.
Journal of neurophysiology.
80(3):1567-70
[PMID] 9744962.
1998
AMPA receptor properties in adult rat hippocampus following environmental enrichment.
Brain research.
799(1):16-25
[PMID] 9666061.
1998
GABA(b) receptors differentially regulate hippocampal CA1 excitatory synaptic transmission across postnatal development in the rat.
Neuroscience letters.
248(2):138-40
[PMID] 9654362.
1998
Late developmental changes in the ability of adenosine A1 receptors to regulate synaptic transmission in the hippocampus.
Brain research. Developmental brain research.
105(1):137-9
[PMID] 9497087.
1998
On slices, synaptosomes and dissociated neurones to study in vitro ageing physiology.
Trends in neurosciences.
21(7):286-7
[PMID] 9683319.
1998
Reversal of age-related alterations in synaptic plasticity by blockade of L-type Ca2+ channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
18(9):3171-9
[PMID] 9547225.
1998
Sex differences in the activational effect of ERalpha on spatial learning.
Hormones and behavior.
34(2):163-70
[PMID] 9799626.
1997
Age-associated changes in Ca(2+)-dependent processes: relation to hippocampal synaptic plasticity.
Hippocampus.
7(6):602-12
[PMID] 9443057.
1997
Development of metabotropic glutamate receptor-mediated synaptic inhibition.
Neuroreport.
8(13):2919-24
[PMID] 9376531.
1997
Insensitivity of the hippocampus to environmental stimulation during postnatal development.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
17(20):7967-73
[PMID] 9315914.
1996
Age and stress history effects on spatial performance in a swim task in Fischer-344 rats.
Neurobiology of learning and memory.
66(1):1-10
[PMID] 8661246.
1996
Increased susceptibility to induction of long-term depression and long-term potentiation reversal during aging.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
16(17):5382-92
[PMID] 8757251.
1996
Mechanism of altered synaptic strength due to experience: relation to long-term potentiation.
Brain research.
736(1-2):243-50
[PMID] 8930330.
1995
Developmental increase in CA3-CA1 presynaptic function in the hippocampal slice.
Journal of neurophysiology.
73(5):1821-8
[PMID] 7623083.
1994
Persistent increase of hippocampal presynaptic axon excitability after repetitive electrical stimulation: dependence on N-methyl-D-aspartate receptor activity, nitric-oxide synthase, and temperature.
Proceedings of the National Academy of Sciences of the United States of America.
91(11):4830-4
[PMID] 7515179.
1992
Acetylcholine modulates averaged sensory evoked responses and perforant path evoked field potentials in the rat dentate gyrus.
Brain research.
587(1):95-101
[PMID] 1525653.
1992
Region-specific age effects on AMPA sensitivity: electrophysiological evidence for loss of synaptic contacts in hippocampal field CA1.
Hippocampus.
2(4):457-68
[PMID] 1284976.
1991
Increase in perforant path quantal size in aged F-344 rats.
Neurobiology of aging.
12(5):441-8
[PMID] 1770978.
1991
Long-term enhancement of CA1 synaptic transmission is due to increased quantal size, not quantal content.
Hippocampus.
1(1):79-91
[PMID] 1669344.
1991
Specificity of functional changes during normal brain aging.
Annals of the New York Academy of Sciences.
640:80-5
[PMID] 1776764.
1989
Effects of delta-9-tetrahydrocannabinol on sensory evoked hippocampal activity in the rat: principal components analysis and sequential dependency.
The Journal of pharmacology and experimental therapeutics.
251(3):870-7
[PMID] 2557421.
1989
Spatial selectivity of rat hippocampal neurons: dependence on preparedness for movement.
Science (New York, N.Y.).
244(4912):1580-2
[PMID] 2740902.
1988
Control of sensory activation of granule cells in the fascia dentata by extrinsic afferents: septal and entorhinal inputs.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
8(10):3869-78
[PMID] 3193182.
1987
Sequential dependencies regulate sensory evoked responses of single units in the rat hippocampus.
Brain research.
408(1-2):86-96
[PMID] 3594233.
1986
delta 9-Tetrahydrocannabinol differentially affects sensory-evoked potentials in the rat dentate gyrus.
The Journal of pharmacology and experimental therapeutics.
239(3):936-40
[PMID] 3025423.
1986
Effects of delta 9-tetrahydrocannabinol on sensory-evoked discharges of granule cells in the dentate gyrus of behaving rats.
The Journal of pharmacology and experimental therapeutics.
239(3):941-5
[PMID] 3025424.
1985
Sequence-related changes in sensory-evoked potentials in the dentate gyrus: a mechanism for item-specific short-term information storage in the hippocampus.
Behavioral and neural biology.
44(2):201-12
[PMID] 4062774.
Grants
Aug 2022
ACTIVE
Sepsis and the Systemic Cytokine Storm in Aging and Alzheimer Disease Models
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Jun 2022
ACTIVE
University of Florida Claude D. Pepper Older Americans Independence Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Jul 2021
– Jun 2023
Seven tesla preclinical MRI/S scanner for structural, functional and molecular imaging
Role: Other
Funding: NATL INST OF HLTH OD
Jul 2020
– May 2021
Collaboratory on Research Definitions for Cognitive Reserve and Resilience
Role: Principal Investigator
Funding: COLUMBIA UNIVERSITY
via NATL INST OF HLTH NIA
May 2020
ACTIVE
Biobehavioral basis of knee osteoarthritis pain
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Jul 2018
– Mar 2024
Estrogen and cognition over the lifespan
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Apr 2017
– Mar 2022
University of Florida Claude D. Pepper Older Americans Independence Center (OAIC)
Role: Project Manager
Funding: NATL INST OF HLTH NIA
May 2016
– Apr 2022
Systemic inflammation in regulating the onset and progression of brain aging
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Apr 2016
– Mar 2017
Claude D Pepper Older Americans Independence Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Sep 2015
– Apr 2020
Systemic inflammation in regulating the onset and progression of brain aging
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Sep 2015
– Feb 2019
Targeting the Chaperone Pathway for Myelin Repair in Hereditary Neuropathies
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Aug 2015
– Jul 2023
Molecular Genetic Characterization of SCA8
Role: Co-Project Director/Principal Investigator
Funding: NATL INST OF HLTH NINDS
Apr 2015
– Mar 2016
Claude D. Pepper Older Americans Independence Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Sep 2014
– Apr 2019
Signaling cascades and memory deficits during aging
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Aug 2011
– May 2017
Estrogen and cognition over the lifespan
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Nov 2009
– Sep 2022
McKnight Chair UFFND Endowment Income Funds to establish Medical Research of the Brain
Role: Principal Investigator
Funding: UF FOUNDATION
Contact Details
Phones:
- Business:
- (352) 273-0033
Emails:
- Business:
- foster1@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100244
GAINESVILLE FL 32610 - Business Street:
-
100 NEWELL DR
GAINESVILLE FL 32611