Catherine Flores,
Associate Professor
Department:
MD-NEUROLOGICAL SURGERY
Business Phone:
(352) 273-9000
Business Email:
catherine.flores@neurosurgery.ufl.edu
Teaching Profile
Courses Taught
2018,2020-2024
GMS6382 Special Topics in Immunology
2018,2023-2024
GMS7979 Advanced Research
2018,2024-2025
GMS7980 Research for Doctoral Dissertation
2016
GMS7794 Neuroscience Seminar
2021-2025
GMS6140 Principles of Immunology
2021
GMS6383 Current Topics in Immunotherapy
2022,2024
GMS6090 Research in Medical Sciences
2022,2024-2025
GMS6905 Independent Studies in Medical Sciences
2023
GMS6971 Research for Master’s Thesis
2024-2025
GMS6691 Special Topics in Cell Biology and Anatomy
Publications
Academic Articles
2024
Development of a murine laser interstitial thermotherapy system.
Neurosurgical focus.
57(5)
[DOI] 10.3171/2024.8.FOCUS24452.
[PMID] 39486063.
2024
In vivo mouse models for adult brain tumors: Exploring tumorigenesis and advancing immunotherapy development.
Neuro-oncology.
26(11):1964-1980
[DOI] 10.1093/neuonc/noae131.
[PMID] 38990913.
2024
mRNA-based precision targeting of neoantigens and tumor-associated antigens in malignant brain tumors.
Genome medicine.
16(1)
[DOI] 10.1186/s13073-024-01281-z.
[PMID] 38268001.
2023
Evaluation of an Adoptive Cellular Therapy-Based Vaccine in a Transgenic Mouse Model of α-synucleinopathy.
ACS chemical neuroscience.
14(2):235-245
[DOI] 10.1021/acschemneuro.2c00539.
[PMID] 36571847.
2023
Immunotherapy reverses glioma-driven dysfunction of immune system homeostasis.
Journal for immunotherapy of cancer.
11(2)
[DOI] 10.1136/jitc-2022-004805.
[PMID] 36750252.
2022
Is There a Role for Immunotherapy in Central Nervous System Cancers?
Hematology/oncology clinics of North America.
36(1):237-252
[DOI] 10.1016/j.hoc.2021.09.002.
[PMID] 34801163.
2022
The current landscape of immunotherapy for pediatric brain tumors.
Nature cancer.
3(1):11-24
[DOI] 10.1038/s43018-021-00319-0.
[PMID] 35121998.
2021
Brain stem gliomas and current landscape.
Journal of neuro-oncology.
151(1):21-28
[DOI] 10.1007/s11060-020-03655-w.
[PMID] 33398531.
2021
Considerations when treating high-grade pediatric glioma patients with immunotherapy.
Expert review of neurotherapeutics.
21(2):205-219
[DOI] 10.1080/14737175.2020.1855144.
[PMID] 33225764.
2021
Myelopoiesis during Solid Cancers and Strategies for Immunotherapy.
Cells.
10(5)
[DOI] 10.3390/cells10050968.
[PMID] 33919157.
2020
Immune Escape After Adoptive T-cell Therapy for Malignant Gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research.
26(21):5689-5700
[DOI] 10.1158/1078-0432.CCR-20-1065.
[PMID] 32788225.
2020
Ultrahigh-Performance Liquid Chromatography-High-Resolution Mass Spectrometry Metabolomics and Lipidomics Study of Stool from Transgenic Parkinson’s Disease Mice Following Immunotherapy.
Journal of proteome research.
19(1):424-431
[DOI] 10.1021/acs.jproteome.9b00605.
[PMID] 31713431.
2019
Concise Review: Modulating Cancer Immunity with Hematopoietic Stem and Progenitor Cells.
Stem cells (Dayton, Ohio).
37(2):166-175
[DOI] 10.1002/stem.2933.
[PMID] 30353618.
2019
Modulation of temozolomide dose differentially affects T-cell response to immune checkpoint inhibition.
Neuro-oncology.
21(6):730-741
[DOI] 10.1093/neuonc/noz015.
[PMID] 30668768.
2019
Quantitative characterization of 3D bioprinted structural elements under cell generated forces.
Nature communications.
10(1)
[DOI] 10.1038/s41467-019-10919-1.
[PMID] 31292444.
2019
RNA-Modified T Cells Mediate Effective Delivery of Immunomodulatory Cytokines to Brain Tumors.
Molecular therapy : the journal of the American Society of Gene Therapy.
27(4):837-849
[DOI] 10.1016/j.ymthe.2018.10.007.
[PMID] 30448196.
2018
Cross-talk between T Cells and Hematopoietic Stem Cells during Adoptive Cellular Therapy for Malignant Glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
24(16):3955-3966
[DOI] 10.1158/1078-0432.CCR-17-3061.
[PMID] 29712687.
2018
Lin-CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade.
Nature communications.
9(1)
[DOI] 10.1038/s41467-018-06182-5.
[PMID] 30333482.
2017
Systemic activation of antigen-presenting cells via RNA-loaded nanoparticles.
Oncoimmunology.
6(1)
[DOI] 10.1080/2162402X.2016.1256527.
[PMID] 28197373.
2016
Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
22(3):582-95
[DOI] 10.1158/1078-0432.CCR-15-0713.
[PMID] 26405194.
2015
Bridging infectious disease vaccines with cancer immunotherapy: a role for targeted RNA based immunotherapeutics.
Journal for immunotherapy of cancer.
3
[DOI] 10.1186/s40425-015-0058-0.
[PMID] 25901285.
2015
Novel role of hematopoietic stem cells in immunologic rejection of malignant gliomas.
Oncoimmunology.
4(3)
[PMID] 25949916.
2015
Rna Nanoparticle Vaccines Facilitate and Sustain Adoptive Cellular Therapy Targeting Pediatric Intracranial Malignancies
Pediatric Blood & Cancer.
62(2)
2014
EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss.
Clinical cancer research : an official journal of the American Association for Cancer Research.
20(4):972-84
[DOI] 10.1158/1078-0432.CCR-13-0709.
[PMID] 24352643.
2013
A cytokine cocktail directly modulates the phenotype of DC-enriched anti-tumor T cells to convey potent anti-tumor activities in a murine model.
Cancer immunology, immunotherapy : CII.
62(11):1649-62
[DOI] 10.1007/s00262-013-1464-0.
[PMID] 23982483.
2013
Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.
PloS one.
8(3)
[DOI] 10.1371/journal.pone.0059082.
[PMID] 23527092.
2012
Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer.
Journal of applied physiology (Bethesda, Md. : 1985).
113(2):263-72
[DOI] 10.1152/japplphysiol.01575.2011.
[PMID] 22604887.
2010
Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation.
Cancer research.
70(22):9329-38
[DOI] 10.1158/0008-5472.CAN-10-1854.
[PMID] 20884629.
Grants
Jun 2024
ACTIVE
CHAMP1ON – Combinatorial Hematopoietic Stem Cell And Monoclonal Antibody PD-1 Blockade Phase 1 "Window of Opportunity" Trial for RecurreNt Pediatric High-Grade Glioma
Role: Co-Investigator
Funding: FL DEPT OF HLTH LIVE LIKE BELLA
Aug 2023
ACTIVE
Developmentally regulated antigens for immunologic targeting of pediatric brain tumors
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2023
ACTIVE
The Sunshine Project: Understanding Major Immunological Mechanisms That Allow Therapy to Overcome Treatment Resistance in Refractory Pediatric Tumors
Role: Principal Investigator
Funding: H LEE MOFFITT CANCER CTR & RES INST
via NATL PEDIATRIC CANCER FOU
Jun 2023
ACTIVE
Immunotherapy for Synucleinopathies: Can Gut Microbiota Affect Efficacy?
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Jan 2022
– Jun 2023
Understanding Major Immunological Mechanisms That Allow Therapy to Overcome Treatment Resistance in Refractory Pediatric Tumors
Role: Principal Investigator
Funding: H LEE MOFFITT CANCER CTR & RES INST
via NATL PEDIATRIC CANCER FOU
Sep 2021
– Sep 2022
SRB Thank you – Flores
Role: Principal Investigator
Funding: ALEXS LEMONADE STAND FOUNDATION
Jul 2021
ACTIVE
F30 (Francis) Thymic PD-1 blockade mediates the anti-tumor immune response in pediatric high-grade glioma
Role: Other
Funding: NATL INST OF HLTH NCI
Jul 2021
– Apr 2025
A consortium effort to translate therapies for neurological diseases via an immune-competent organotypic platform
Role: Principal Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL
via NATL INST OF HLTH NCATS
Sep 2020
ACTIVE
Hematopoietic stem cells overcome treatment resistance to PD-1 blockade against brain tumors
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Oct 2019
– Mar 2021
The use of hematopoietic stem and progenitor cells to reverse treatment resistance to PD-1 blockade
Role: Principal Investigator
Funding: ALEXS LEMONADE STAND FOUNDATION
Sep 2019
– Aug 2022
Adoptive Cell Therapies and Translational Neuroimaging in Synucleinopathy: Implications for Dementia with Lewy Body and Parkinson's Disease
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Sep 2019
– Jun 2024
Hematopoietic stem cells overcome treatment resistance to adoptive cellular therapy against malignant gliomas
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2019
– Mar 2021
Engineering T cell metabolic fitness to treat pediatric brain tumors
Role: Co-Investigator
Funding: ST BALDRICKS FOUNDATION
Jan 2018
– Dec 2019
Enhancing efficacy of adoptive immunotherapy against DIPG using hematopoietic stem cells
Role: Principal Investigator
Funding: MULTIPLE SPONSORS
Jul 2017
– Jun 2019
FIorida Center for Brain Tumor Research (FCBTR)
Role: Project Manager
Funding: ACCELERATE BRAIN CANCER CURE
Jun 2017
– Oct 2019
Evaluating the use of hematopoietic stem cells in overcoming immunosuppression within the brain tumor microenvironment
Role: Principal Investigator
Funding: AMER BRAIN TUMOR ASSOCIATION
Jun 2017
– May 2018
Flores – ALFS Equipment Award
Role: Principal Investigator
Funding: ALEXS LEMONADE STAND FOUNDATION
May 2017
– Aug 2017
Pediatric Oncology Student Training (POST) Program
Role: Principal Investigator
Funding: ALEXS LEMONADE STAND FOUNDATION
Jul 2015
– Sep 2020
Novel role of hematopoietic stem cells in immunologic rejection of malignant pediatric brain tumors
Role: Principal Investigator
Funding: ALEXS LEMONADE STAND FOUNDATION
Jul 2013
– Jun 2021
Florida Center for Brain Tumor Research – Statewide Brain Tumor Registry Program at the McKnight Brain Institute
Role: Project Manager
Funding: FL DEPT OF HLTH
Contact Details
Phones:
- Business:
- (352) 273-9000
Emails:
- Business:
- catherine.flores@neurosurgery.ufl.edu
Addresses:
- Business Mailing:
-
PO BOX 100265
DEPARTMENT OF NEUROSURGERY
GAINESVILLE FL 326100265 - Business Street:
-
DEPARTMENT OF NEUROSURGERY
GAINESVILLE FL 32611