Jeremy J Flint

Jeremy J Flint

Assistant Scientist

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 294-8451
Business Email: jflint@mbi.ufl.edu

About Jeremy J Flint

Dr. Jeremy Flint graduated summa cum laude from UF’s Interdisciplinary studies (IDS) program with a Bachelor of Science in Cell and Molecular Neurobiology (2002). He attended the University of Florida’s interdisciplinary program in biomedical sciences with a concentration in neuroscience for his Ph.D (2009). After performing postdoctoral studies in the laboratory of Dr. Stephen Blackband, he accepted a post as an Assistant Scientist in UF’s Department of Neuroscience (2014). Dr. Flint’s research program is dedicated to using magnetic resonance microscopy (MRM) techniques to study the MR contrast properties of cells: specifically, the diffusion-based MR contrast properties of mammalian neurons. Given the unique and important role MRI plays in our ability to perform non-invasive imaging of the human brain, the ultimate goal of Dr. Flint’s work is to improve the diagnostic utility of clinical imaging protocols through an understanding of how early-stage neuropathologies affect the MR contrast properties of CNS tissues at the cellular level.

Accomplishments

LRP Award
2010-2012 · National Institutes of Health
Grinter Fellowship
2004-2007 · University of Florida

Research Profile

One of the most significant limitations of MRI is its inherent lack of sensitivity which reduces the ultimate image resolution achievable under practical conditions. Dr. Flint’s research program focuses on overcoming this limitation by employing state-of-the art spectrometer systems and radio frequency (RF) coil technology to maximize the available MR signal generated. In this way, tissue components too small to visualize in the clinic—such as cells—can be imaged and studied with excised models in the laboratory. Using ultra-high-field imaging systems available to him through the National High Magnetic Field Lab’s (NHMFL) Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS) facility at UF, Dr. Flint is able to conduct studies at sub-100um resolutions that comprise a subfield of MRI know as Magnetic Resonance Microscopy (MRM). His time spent performing MRM research at UF has resulted in some of the most significant high-resolution MR images to date which include the first direct visualization of mammalian neurons—including human neurons—and most recently the first MRM of live mammalian neurons. To enable work on living tissues, Dr. Flint designs and fabricates purpose-built, MRI-compatible micro perfusion systems that maintain the viability of acute or organotypic slice cultures and cell culture samples during prolonged periods of image collection. Dr. Flint believes that cellular-level characterization of MR contrast properties in excised tissues will be useful for informing how contrast changes in macroscopic scans—such as are collected routinely in the clinic—relate to pathology occurring at the cellular level. Such knowledge would give clinicians a means to detect and monitor the earliest stages of disease progression which would lead to earlier treatment and, subsequently, improved patient outcomes.

Areas of Interest
  • Advanced MRI and stroke
  • neuroscience
  • traumatic brain injury

Publications

Grants

Aug 2020 ACTIVE
VA Intergovernmental Personnel Act Assignment Agreement for Flint
US DEPT OF VET AFF GAINESVILLE MED CTR · Principal Investigator
Jul 2016 – Jun 2020
diffusion functional imaging (dfmri) of evoked neuronal activation at the cellular level
NATL INST OF HLTH NINDS · Principal Investigator

Education

Ph.D. (Neuroscience)
2004-2009 · University of Florida
B.S. (Cell and Molecular Neurobiology)
1998-2002 · University of Florida

Contact Details

Phones:
Business:
(352) 294-8451
Emails:
Business:
jflint@mbi.ufl.edu