Darin J Falk,
Research Assistant Professor
Teaching Profile
Courses Taught
2018
GMS7593 Topics in Pharmacology and Toxicology
2018
BME7980 Research for Doctoral Dissertation
2016
GMS7794 Neuroscience Seminar
Publications
Academic Articles
2024
Neonatal systemic gene therapy restores cardiorespiratory function in a rat model of Pompe disease.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.12.10.627800.
[PMID] 39763722.
2019
AAV Gene Therapy Utilizing Glycosylation-Independent Lysosomal Targeting Tagged GAA in the Hypoglossal Motor System of Pompe Mice.
Molecular therapy. Methods & clinical development.
15:194-203
[DOI] 10.1016/j.omtm.2019.08.009.
[PMID] 31660421.
2019
HSP90 Inhibitor, NVP-AUY922, Improves Myelination in Vitro and Supports the Maintenance of Myelinated Axons in Neuropathic Mice.
ACS chemical neuroscience.
10(6):2890-2902
[DOI] 10.1021/acschemneuro.9b00105.
[PMID] 31017387.
2019
Reduction of Autophagic Accumulation in Pompe Disease Mouse Model Following Gene Therapy.
Current gene therapy.
19(3):197-207
[DOI] 10.2174/1566523219666190621113807.
[PMID] 31223086.
2018
A Neuron-Specific Gene Therapy Relieves Motor Deficits in Pompe Disease Mice.
Molecular neurobiology.
55(6):5299-5309
[DOI] 10.1007/s12035-017-0763-4.
[PMID] 28895054.
2018
Locomotor and skeletal muscle abnormalities in trembler J neuropathic mice.
Muscle & nerve.
57(4):664-671
[DOI] 10.1002/mus.25987.
[PMID] 29023846.
2018
Mechanical Ventilation for Duchenne Muscular Dystrophy: Sinner or Saint?
Muscle & nerve.
57(3):353-355
[DOI] 10.1002/mus.25986.
[PMID] 29023941.
2017
13C/31P MRS Metabolic Biomarkers of Disease Progression and Response to AAV Delivery of hGAA in a Mouse Model of Pompe Disease.
Molecular therapy. Methods & clinical development.
7:42-49
[DOI] 10.1016/j.omtm.2017.09.002.
[PMID] 29018835.
2016
A scalable method for the production of high-titer and high-quality adeno-associated type 9 vectors using the HSV platform.
Molecular therapy. Methods & clinical development.
3
[DOI] 10.1038/mtm.2016.31.
[PMID] 27222839.
2016
Copackaged AAV9 Vectors Promote Simultaneous Immune Tolerance and Phenotypic Correction of Pompe Disease.
Human gene therapy.
27(1):43-59
[DOI] 10.1089/hum.2015.103.
[PMID] 26603344.
2016
Neuropathology in respiratory-related motoneurons in young Pompe (Gaa(-/-)) mice.
Respiratory physiology & neurobiology.
227:48-55
[DOI] 10.1016/j.resp.2016.02.007.
[PMID] 26921786.
2016
Transcriptome assessment of the Pompe (Gaa-/-) mouse spinal cord indicates widespread neuropathology.
Physiological genomics.
48(11):785-794
[DOI] 10.1152/physiolgenomics.00075.2016.
[PMID] 27614205.
2015
Altered activation of the tibialis anterior in individuals with Pompe disease: Implications for motor unit dysfunction.
Muscle & nerve.
51(6):877-83
[DOI] 10.1002/mus.24444.
[PMID] 25186912.
2015
Comparative impact of AAV and enzyme replacement therapy on respiratory and cardiac function in adult Pompe mice.
Molecular therapy. Methods & clinical development.
2
[DOI] 10.1038/mtm.2015.7.
[PMID] 26029718.
2015
Correcting Neuromuscular Deficits With Gene Therapy in Pompe Disease.
Annals of neurology.
78(2):222-34
[DOI] 10.1002/ana.24433.
[PMID] 25925726.
2015
Endurance training ameliorates complex 3 deficiency in a mouse model of Barth syndrome.
Journal of inherited metabolic disease.
38(5):915-22
[DOI] 10.1007/s10545-015-9834-8.
[PMID] 25860817.
2015
Peripheral nerve and neuromuscular junction pathology in Pompe disease.
Human molecular genetics.
24(3):625-36
[DOI] 10.1093/hmg/ddu476.
[PMID] 25217571.
2015
Stimulation of Respiratory Motor Output and Ventilation in a Murine Model of Pompe Disease by Ampakines.
American journal of respiratory cell and molecular biology.
53(3):326-35
[DOI] 10.1165/rcmb.2014-0374OC.
[PMID] 25569118.
2014
Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice.
Neurobiology of disease.
70:224-36
[DOI] 10.1016/j.nbd.2014.06.023.
[PMID] 25014022.
2014
Sustained correction of motoneuron histopathology following intramuscular delivery of AAV in pompe mice.
Molecular therapy : the journal of the American Society of Gene Therapy.
22(4):702-12
[DOI] 10.1038/mt.2013.282.
[PMID] 24336173.
2013
Adeno-associated virus-mediated gene therapy for metabolic myopathy.
Human gene therapy.
24(11):928-36
[DOI] 10.1089/hum.2013.2514.
[PMID] 24164240.
2013
Delivery of recombinant adeno-associated virus vectors to rat diaphragm muscle via direct intramuscular injection.
Human gene therapy methods.
24(6):364-71
[DOI] 10.1089/hgtb.2013.055.
[PMID] 24006956.
2013
Intrapleural administration of AAV9 improves neural and cardiorespiratory function in Pompe disease.
Molecular therapy : the journal of the American Society of Gene Therapy.
21(9):1661-7
[DOI] 10.1038/mt.2013.96.
[PMID] 23732990.
2013
Liposomes to target peripheral neurons and Schwann cells.
PloS one.
8(11)
[DOI] 10.1371/journal.pone.0078724.
[PMID] 24244347.
2013
The respiratory neuromuscular system in Pompe disease.
Respiratory physiology & neurobiology.
189(2):241-9
[DOI] 10.1016/j.resp.2013.06.007.
[PMID] 23797185.
2012
An acidic oligopeptide displayed on AAV2 improves axial muscle tropism after systemic delivery.
Genetic vaccines and therapy.
10(1)
[DOI] 10.1186/1479-0556-10-3.
[PMID] 22709483.
2012
Gene therapy approaches for lysosomal storage disease: next-generation treatment.
Human gene therapy.
23(8):808-15
[DOI] 10.1089/hum.2012.140.
[PMID] 22794786.
2012
Putting the spice in weaning*.
Critical care medicine.
40(3):1022-3
[DOI] 10.1097/CCM.0b013e31823e96c2.
[PMID] 22343867.
2012
Retrograde gene delivery to hypoglossal motoneurons using adeno-associated virus serotype 9.
Human gene therapy methods.
23(2):148-56
[DOI] 10.1089/hgtb.2012.009.
[PMID] 22693957.
2012
Spinal delivery of AAV vector restores enzyme activity and increases ventilation in Pompe mice.
Molecular therapy : the journal of the American Society of Gene Therapy.
20(1):21-7
[DOI] 10.1038/mt.2011.214.
[PMID] 22008916.
2011
Characterization of a transgenic short hairpin RNA-induced murine model of Tafazzin deficiency.
Human gene therapy.
22(7):865-71
[DOI] 10.1089/hum.2010.199.
[PMID] 21091282.
2011
Hypoglossal neuropathology and respiratory activity in pompe mice.
Frontiers in physiology.
2
[DOI] 10.3389/fphys.2011.00031.
[PMID] 21747768.
2011
Mechanical ventilation-induced oxidative stress in the diaphragm: role of heme oxygenase-1.
Chest.
139(4):816-824
[DOI] 10.1378/chest.09-2787.
[PMID] 21106654.
2011
Pompe disease gene therapy.
Human molecular genetics.
20(R1):R61-8
[DOI] 10.1093/hmg/ddr174.
[PMID] 21518733.
2010
Adeno-associated virus-mediated correction of a canine model of glycogen storage disease type Ia.
Human gene therapy.
21(7):903-10
[DOI] 10.1089/hum.2009.157.
[PMID] 20163245.
2010
Gel-mediated delivery of AAV1 vectors corrects ventilatory function in Pompe mice with established disease.
Molecular therapy : the journal of the American Society of Gene Therapy.
18(3):502-10
[DOI] 10.1038/mt.2009.305.
[PMID] 20104213.
2009
Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilation.
Critical care medicine.
37(4):1373-9
[DOI] 10.1097/CCM.0b013e31819cef63.
[PMID] 19242334.
2009
Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunction.
Journal of applied physiology (Bethesda, Md. : 1985).
106(2):385-94
[DOI] 10.1152/japplphysiol.91106.2008.
[PMID] 18974366.
2008
Redox regulation of diaphragm proteolysis during mechanical ventilation.
American journal of physiology. Regulatory, integrative and comparative physiology.
294(5):R1608-17
[DOI] 10.1152/ajpregu.00044.2008.
[PMID] 18321950.
2007
Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling.
The Journal of physiology.
585(Pt 1):203-15
[PMID] 17916612.
2007
Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilation-induced atrophy.
American journal of respiratory and critical care medicine.
175(2):150-9
[PMID] 17082496.
2007
Diaphragmatic nitric oxide synthase is not induced during mechanical ventilation.
Journal of applied physiology (Bethesda, Md. : 1985).
102(1):157-62
[PMID] 16931563.
2007
Diaphragmatic proteasome function is maintained in the ageing Fisher 344 rat.
Experimental physiology.
92(5):895-901
[PMID] 17631517.
2006
Ischemia-reperfusion-induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibition.
American journal of physiology. Heart and circulatory physiology.
290(1):H128-36
[PMID] 16155100.
2006
Mechanical ventilation promotes redox status alterations in the diaphragm.
Journal of applied physiology (Bethesda, Md. : 1985).
101(4):1017-24
[PMID] 16675618.
2006
Moderate caloric restriction increases diaphragmatic antioxidant enzyme mRNA, but not when combined with lifelong exercise.
Antioxidants & redox signaling.
8(3-4):539-47
[PMID] 16677098.
2005
Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragm.
Journal of applied physiology (Bethesda, Md. : 1985).
98(4):1314-21
[PMID] 15557010.
2005
Reloading the diaphragm following mechanical ventilation does not promote injury.
Chest.
127(6):2204-10
[PMID] 15947338.
2004
Trolox attenuates mechanical ventilation-induced diaphragmatic dysfunction and proteolysis.
American journal of respiratory and critical care medicine.
170(11):1179-84
[PMID] 15374845.
2003
Effects of effervescent creatine, ribose, and glutamine supplementation on muscular strength, muscular endurance, and body composition.
Journal of strength and conditioning research.
17(4):810-6
[PMID] 14636104.
2002
Effects of norandrostenedione and norandrostenediol in resistance-trained men.
Nutrition (Burbank, Los Angeles County, Calif.).
18(9):734-7
[PMID] 12297208.
2001
The effects of supplementation with 19-nor-4-androstene-3,17-dione and 19-nor-4-androstene-3,17-diol on body composition and athletic performance in previously weight-trained male athletes.
European journal of applied physiology.
84(5):426-31
[PMID] 11417430.
1998
Characterization of staphylococcal bovine mastitis isolates using the polymerase chain reaction.
Journal of food protection.
61(10):1384-6
[PMID] 9798161.
Grants
Sep 2015
– Feb 2019
Targeting the Chaperone Pathway for Myelin Repair in Hereditary Neuropathies
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
May 2015
– May 2016
Targeted therapy for motoneuron pathology in Pompe disease
Role: Principal Investigator
Funding: RARE DISEASE FOUNDATION
Jan 2015
– Sep 2016
Advanced Gene Therapy for Treatment of Cardiomyopathy and Respiratory Insufficiency in Pompe Disease
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Dec 2014
– Dec 2016
AAV9 Pompe Rodent Study
Role: Project Manager
Funding: AUDENTES THERAPEUTICS
Sep 2014
– Sep 2018
Pathogenesis of the neuromuscular synapse in Pompe disease
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Jul 2007
– Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU
Contact Details
Phones:
- Business:
- (352) 273-6549
Emails:
- Business:
- falkd@ufl.edu
Addresses:
- Business Mailing:
-
580 W 8TH ST
JACKSONVILLE FL 32209 - Business Street:
-
580 W 8TH ST
JACKSONVILLE FL 32209