Robert M Caudle

Robert M Caudle,

PROFESSOR

Department: DN-NEUROSCIENCE
Business Phone: (352) 273-6767
Business Email: caudle@ufl.edu

Teaching Profile

Courses Taught
2009-2023
DEN6251 Clin Manage Dent Pain
2007,2011-2022,2022-2025
DEN5120C Physiology
2017-2019,2021
GMS6705 Functional Human Neuroanatomy
2017-2019,2021-2024,2023-2024
GMS6070 Sensory and Motor Systems
2018
DEN6910 Supervised Research
2011-2012,2018
DEN6971 Research for Master’s Thesis
2012,2014-2016,2016
DEN6678 Advanced Oral Medicine and Drug Interactions in Dentistry
2013-2014,2016
DEN6681 Craniofacial Pathobiology
2012-2015
DEN6680 Principles and Craniofacial Biology and Emerging Therapies
2006,2015
GMS6711 Neurobiology of Pain
2009,2014
DEN6905 Individual Study
2013-2014
DEN7540 Special Topics
2011-2012
GMS6161 Introduction to Oral Biology II
2011
GMS6160 Introduction to Oral Biology I
2022-2023
GMS6701 Functional and Comparative Neuroanatomy for Professionals
2023
GMS7795 Special Topics in Neuroscience

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-2394-4114

Publications

2023
An ethogram analysis of cutaneous thermal pain sensitivity and oxycodone reward-related behaviors in rats.
Research square. [DOI] 10.21203/rs.3.rs-2679319/v1. [PMID] 36993634.
2023
An ethogram analysis of cutaneous thermal pain sensitivity and oxycodone reward-related behaviors in rats.
Scientific reports. 13(1) [DOI] 10.1038/s41598-023-36729-6. [PMID] 37380739.
2023
Influence of TRPV1 on Thermal Nociception in Rats with Temporomandibular Joint Persistent Inflammation Evaluated by the Operant Orofacial Pain Assessment Device (OPAD).
Journal of pain research. 16:2047-2062 [DOI] 10.2147/JPR.S405258. [PMID] 37342611.
2023
Locus coeruleus-noradrenergic modulation of trigeminal pain: Implications for trigeminal neuralgia and psychiatric comorbidities.
Neurobiology of pain (Cambridge, Mass.). 13 [DOI] 10.1016/j.ynpai.2023.100124. [PMID] 36974102.
2022
Assessment of Nerve Injury-induced Mechanical Hypersensitivity in Rats using an Orofacial Operant Pain Assay.
Journal of visualized experiments : JoVE. (185) [DOI] 10.3791/64221. [PMID] 35969082.
2022
Effects of Oxaliplatin on Facial Sensitivity to Cool Temperatures and TRPM8 Expressing Trigeminal Ganglion Neurons in Mice.
Frontiers in pain research (Lausanne, Switzerland). 3 [DOI] 10.3389/fpain.2022.868547. [PMID] 35634452.
2022
Oxycodone decreases anxiety-like behavior in the elevated plus-maze test in male and female rats.
Behavioural pharmacology. 33(6):418-426 [DOI] 10.1097/FBP.0000000000000690. [PMID] 35947068.
2021
Editorial: Verification of Animal Pain Models by Reverse Translation.
Frontiers in pharmacology. 12 [DOI] 10.3389/fphar.2021.778880. [PMID] 34690791.
2020
Pharmacological Characterization of Orofacial Nociception in Female Rats Following Nitroglycerin Administration.
Frontiers in pharmacology. 11 [DOI] 10.3389/fphar.2020.527495. [PMID] 33343340.
2018
Behavioral characteristics of capsaicin mediated cutaneous, myogenic, and arthrogenic orofacial nociception in rats.
Archives of oral biology. 92:18-24 [DOI] 10.1016/j.archoralbio.2018.04.013. [PMID] 29738922.
2018
Pain control through selective chemo-axotomy of centrally projecting TRPV1+ sensory neurons
Journal of Clinical Investigation. 128(4):1657-1670 [DOI] 10.1172/jci94331.
2018
Pain control through selective chemo-axotomy of centrally projecting TRPV1+ sensory neurons
Journal of Clinical Investigation. 128(4):1657-1670 [DOI] 10.1172/jci94331.
2017
Advanced glycation endproducts (AGEs) in saliva of patients with multiple myeloma – a pilot study.
Leukemia & lymphoma. 58(12):2934-2938 [DOI] 10.1080/10428194.2017.1344845. [PMID] 28679295.
2017
Effects of cocoa-enriched diet on orofacial pain in a murine model.
Orthodontics & craniofacial research. 20 Suppl 1(Suppl 1):157-161 [DOI] 10.1111/ocr.12149. [PMID] 28643911.
2017
Sex differences in mouse Transient Receptor Potential Cation Channel, Subfamily M, Member 8 expressing trigeminal ganglion neurons
PLOS ONE. 12(5) [DOI] 10.1371/journal.pone.0176753. [PMID] 28472061.
2016
Trigeminal neuroplasticity underlies allodynia in a preclinical model of mild closed head traumatic brain injury (cTBI)
Neuropharmacology. 107:27-39 [DOI] 10.1016/j.neuropharm.2016.03.016. [PMID] 26972829.
2015
A novel operant-based behavioral assay of mechanical allodynia in the orofacial region of rats.
Journal of neuroscience methods. 248:1-6 [DOI] 10.1016/j.jneumeth.2015.03.022. [PMID] 25823368.
2015
Altered Vasoactive Intestinal Peptides Expression in Irritable Bowel Syndrome Patients and Rats With Trinitrobenzene Sulfonic Acid-Induced Colitis
World Journal of Gastroenterology. 21(1):155-163 [DOI] 10.3748/wjg.v21.i1.155. [PMID] 25574088.
2015
Ionic conjugates of lidocaine and sweeteners as better tasting local anesthetics for dentistry.
Journal of materials chemistry. B. 3(43):8492-8498 [DOI] 10.1039/c5tb00674k. [PMID] 32262689.
2015
Phosphorylation of the N-methyl-d-aspartate receptor is increased in the nucleus accumbens during both acute and extended morphine withdrawal.
The Journal of pharmacology and experimental therapeutics. 355(3):496-505 [DOI] 10.1124/jpet.115.227629. [PMID] 26377910.
2014
Operant assays for assessing pain in preclinical rodent models: highlights from an orofacial assay.
Current topics in behavioral neurosciences. 20:121-45 [DOI] 10.1007/7854_2014_332. [PMID] 25103871.
2014
The effects of a co-application of menthol and capsaicin on nociceptive behaviors of the rat on the operant orofacial pain assessment device.
PloS one. 9(2) [DOI] 10.1371/journal.pone.0089137. [PMID] 24558480.
2013
Anti-nociceptive effect of a conjugate of substance P and light chain of botulinum neurotoxin type A.
Pain. 154(11):2547-2553 [DOI] 10.1016/j.pain.2013.07.041. [PMID] 23933181.
2013
Effects of diet-induced obesity on motivation and pain behavior in an operant assay.
Neuroscience. 235:87-95 [DOI] 10.1016/j.neuroscience.2013.01.019. [PMID] 23333672.
2013
Reduction of conditioned pain modulation in humans by naltrexone: an exploratory study of the effects of pain catastrophizing.
Journal of behavioral medicine. 36(3):315-27 [DOI] 10.1007/s10865-012-9424-2. [PMID] 22534819.
2013
Use of the Operant Orofacial Pain Assessment Device (OPAD) to measure changes in nociceptive behavior.
Journal of visualized experiments : JoVE. (76) [DOI] 10.3791/50336. [PMID] 23792907.
2012
Characterization of bilateral trigeminal constriction injury using an operant facial pain assay.
Neuroscience. 224:294-306 [DOI] 10.1016/j.neuroscience.2012.08.015. [PMID] 22909425.
2012
Lesioning of TRPV1 expressing primary afferent neurons prevents PAR-2 induced motility, but not mechanical hypersensitivity in the rat colon.
Neurogastroenterology and motility. 24(3):e125-35 [DOI] 10.1111/j.1365-2982.2011.01848.x. [PMID] 22168801.
2012
Long-term changes in reward-seeking following morphine withdrawal are associated with altered N-methyl-D-aspartate receptor 1 splice variants in the amygdala.
Neuroscience. 223:45-55 [DOI] 10.1016/j.neuroscience.2012.07.037. [PMID] 22863572.
2012
Morphine and MK-801 administration leads to alternative N-methyl-D-aspartate receptor 1 splicing and associated changes in reward seeking behavior and nociception on an operant orofacial assay.
Neuroscience. 214:14-27 [DOI] 10.1016/j.neuroscience.2012.04.032. [PMID] 22531378.
2012
Placebo-induced analgesia in an operant pain model in rats.
Pain. 153(10):2009-2016 [DOI] 10.1016/j.pain.2012.04.026. [PMID] 22871471.
2011
Adaptation of a novel operant orofacial testing system to characterize both mechanical and thermal pain.
Behavioural brain research. 217(2):477-80 [DOI] 10.1016/j.bbr.2010.10.022. [PMID] 20974188.
2011
Effect of caloric and non-caloric sweet reward solutions on thermal facial operant conditioning.
Behavioural brain research. 216(2):723-5 [DOI] 10.1016/j.bbr.2010.08.023. [PMID] 20797411.
2010
Central sensitization in the trigeminal nucleus caudalis produced by a conjugate of substance P and the A subunit of cholera toxin.
The journal of pain. 11(9):838-46 [DOI] 10.1016/j.jpain.2010.05.007. [PMID] 20620120.
2009
Dose-dependent effects of icilin on thermal preference in the hindpaw and face of rats.
The journal of pain. 10(6):646-53 [DOI] 10.1016/j.jpain.2009.01.002. [PMID] 19409862.
2009
NMDA receptor subunit expression and PAR2 receptor activation in colospinal afferent neurons (CANs) during inflammation induced visceral hypersensitivity.
Molecular pain. 5 [DOI] 10.1186/1744-8069-5-54. [PMID] 19772634.
2009
Spinal NMDA NR1 subunit expression following transient TNBS colitis.
Brain research. 1279:109-20 [DOI] 10.1016/j.brainres.2009.04.038. [PMID] 19406112.
2008
Bite Force and Pattern Measurements for Dental Pain Assessment in the Rat
. 447:175-178 [DOI] 10.1016/j.neulet.2008.70.008.
2008
Bite force and pattern measurements for dental pain assessment in the rat.
Neuroscience letters. 447(2-3):175-8 [DOI] 10.1016/j.neulet.2008.10.008. [PMID] 18926882.
2008
Characterization of mouse orofacial pain and the effects of lesioning TRPV1-expressing neurons on operant behavior.
Molecular pain. 4 [DOI] 10.1186/1744-8069-4-43. [PMID] 18828909.
2008
Decreased levels of soluble receptor for advanced glycation end products in patients with primary Sjögren’s syndrome.
Rheumatology international. 28(8):771-6 [DOI] 10.1007/s00296-008-0529-4. [PMID] 18231794.
2008
Identification and immunohistochemical characterization of colospinal afferent neurons in the rat.
Neuroscience. 153(3):803-13 [DOI] 10.1016/j.neuroscience.2008.02.046. [PMID] 18424003.
2008
RAGE mRNA expression and its correlation with nuclear factor kappa beta mRNA expression in inflamed human periradicular tissues.
Journal of endodontics. 34(6):689-92 [DOI] 10.1016/j.joen.2008.02.013. [PMID] 18498890.
2008
Visceral and somatic hypersensitivity in a subset of rats following TNBS-induced colitis.
Pain. 134(1-2):9-15 [PMID] 17481818.
2008
Visceral and somatic hypersensitivity in TNBS-induced colitis in rats.
Digestive diseases and sciences. 53(2):429-35 [PMID] 17703363.
2007
Effects of mu- and kappa-2 opioid receptor agonists on pain and rearing behaviors.
Behavioral and brain functions : BBF. 3 [PMID] 17883847.
2007
Expression of the N-methyl-D-aspartate receptor NR1 splice variants and NR2 subunit subtypes in the rat colon.
Neuroscience. 147(1):164-73 [PMID] 17509768.
2007
Expression of the receptor of advanced glycation end products in the gingival tissue of smokers with generalized periodontal disease and after nornicotine induction in primary gingival epithelial cells.
Journal of periodontology. 78(4):736-41 [PMID] 17397323.
2007
Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin.
BMC neuroscience. 8 [PMID] 17493276.
2006
Characterization of cold sensitivity and thermal preference using an operant orofacial assay.
Molecular pain. 2 [PMID] 17166284.
2006
Differentiation between capsaicin-induced allodynia and hyperalgesia using a thermal operant assay.
Behavioural brain research. 170(2):308-15 [PMID] 16675039.
2006
Memory in astrocytes: a hypothesis.
Theoretical biology & medical modelling. 3 [PMID] 16420689.
2006
Phosphorylation of NMDA NR1 subunits in the myenteric plexus during TNBS induced colitis.
Neuroscience letters. 406(3):250-5 [PMID] 16942839.
2006
Selective up-regulation of NMDA-NR1 receptor expression in myenteric plexus after TNBS induced colitis in rats.
Molecular pain. 2 [PMID] 16417630.
2005
Diverse immunocytochemical expression of opioid receptors in electrophysiologically defined cells of rat dorsal root ganglia.
Journal of chemical neuroanatomy. 29(4):255-64 [PMID] 15927787.
2005
Expression of the receptor of advanced glycation end products in gingival tissues of type 2 diabetes patients with chronic periodontal disease: a study utilizing immunohistochemistry and RT-PCR.
Journal of clinical periodontology. 32(1):40-4 [PMID] 15642057.
2005
Measurement of resiniferatoxin in serum samples by high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 823(2):184-8 [PMID] 16039169.
2005
Peripheral targeting of the trigeminal ganglion via the infraorbital foramen as a therapeutic strategy.
Brain research. Brain research protocols. 15(3):119-26 [PMID] 16024266.
2005
Receptor for advanced glycation end product (RAGE) upregulation in human gingival fibroblasts incubated with nornicotine.
Journal of periodontology. 76(7):1171-4 [PMID] 16018761.
2005
Spinal cord NR1 serine phosphorylation and NR2B subunit suppression following peripheral inflammation.
Molecular pain. 1 [PMID] 16137337.
2005
Use of a novel thermal operant behavioral assay for characterization of orofacial pain sensitivity.
Pain. 116(3):386-395 [DOI] 10.1016/j.pain.2005.05.011. [PMID] 15982812.
2004
Receptor of advanced glycation end product (RAGE) expression in the minor salivary glands of patients with Sjögren’s syndrome: a preliminary study.
Scandinavian journal of rheumatology. 33(3):174-8 [PMID] 15228188.
2003
N-methyl-D-aspartate receptor subunit expression and phosphorylation following excitotoxic spinal cord injury in rats.
Neuroscience letters. 349(1):37-40 [PMID] 12946581.
2003
Resiniferatoxin-induced loss of plasma membrane in vanilloid receptor expressing cells.
Neurotoxicology. 24(6):895-908 [PMID] 14637384.
2002
Measurement of resiniferatoxin in cerebrospinal fluid by high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 780(2):475-9 [PMID] 12401376.
2001
Intrathecally administered cholera toxin blocks allodynia and hyperalgesia in persistent pain models.
The journal of pain. 2(2):118-27 [PMID] 14622833.
2001
Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1.
The Journal of biological chemistry. 276(14):11021-30 [PMID] 11124944.
2000
Co-localization of N-methyl-D-aspartate receptors and substance P (neurokinin-1) receptors in rat spinal cord.
Neuroscience letters. 291(2):61-4 [PMID] 10978574.
2000
Dynorphin: friend or foe?
Pain. 87(3):235-239 [DOI] 10.1016/S0304-3959(00)00360-2. [PMID] 10963903.
1999
Actions of intrathecal diphtheria toxin-substance P fusion protein on models of persistent pain.
Pain. 79(2-3):243-53 [PMID] 10068170.
1999
The kappa opioid agonist GR89,696 blocks hyperalgesia and allodynia in rat models of peripheral neuritis and neuropathy.
Pain. 79(2-3):255-64 [PMID] 10068171.
1998
Adenoviral gene transfer to spinal-cord neurons: intrathecal vs. intraparenchymal administration.
Brain research. 793(1-2):1-6 [PMID] 9630472.
1998
Ifenprodil blocks the excitatory effects of the opioid peptide dynorphin 1-17 on NMDA receptor-mediated currents in the CA3 region of the guinea pig hippocampus.
Neuropeptides. 32(1):87-95 [PMID] 9571650.
1998
Spinal kappa1 and kappa2 opioid binding sites in rats, guinea pigs, monkeys and humans.
Neuroreport. 9(11):2523-5 [PMID] 9721926.
1997
Comments on Andersen et al., Pain, 67 (1996) 369.
Pain. 72(1-2):283-4 [PMID] 9272815.
1997
Good pain, bad pain.
Science (New York, N.Y.). 278(5336):239-40 [PMID] 9340772.
1997
GR89,696 is a kappa-2 opioid receptor agonist and a kappa-1 opioid receptor antagonist in the guinea pig hippocampus.
The Journal of pharmacology and experimental therapeutics. 283(3):1342-9 [PMID] 9400009.
1997
Putative kappa-2 opioid agonists are antihyperalgesic in a rat model of inflammation.
The Journal of pharmacology and experimental therapeutics. 281(1):136-41 [PMID] 9103490.
1994
Fostering young investigators.
Science (New York, N.Y.). 266(5187) [PMID] 7973668.
1994
Kappa 2 opioid receptors inhibit NMDA receptor-mediated synaptic currents in guinea pig CA3 pyramidal cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 14(9):5580-9 [PMID] 7916046.
1993
The demonstration of long latency potentials in the CA1 region of the rat hippocampal slice.
Brain research. 613(2):247-50 [PMID] 8186971.
1993
The misuse of analysis of variance to detect synergy in combination drug studies.
Pain. 55(3):313-317 [DOI] 10.1016/0304-3959(93)90006-B. [PMID] 8121692.
1992
Endogenous opioid regulation of norepinephrine release in guinea pig hippocampus.
Neuroscience letters. 141(1):84-8 [PMID] 1508405.
1992
Kappa-opioids decrease excitatory transmission in the dentate gyrus of the guinea pig hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 12(1):132-41 [PMID] 1345943.
1991
Endogenous opioids released from perforant path modulate norepinephrine actions and inhibitory postsynaptic potentials in guinea pig CA3 pyramidal cells.
The Journal of pharmacology and experimental therapeutics. 258(1):18-26 [PMID] 2072294.
1990
Chronic morphine exposure blocks opioid effects on both the early and late inhibitory postsynaptic potentials in hippocampal CA1 pyramidal cells.
Neuroscience letters. 110(3):349-55 [PMID] 2158024.
1990
Endogenously released opioids inhibit inhibitory post synaptic potentials in guinea pig CA3 pyramidal cells and rat dentate granule cells.
Progress in clinical and biological research. 328:5-8 [PMID] 2154812.
1990
Mu opioid receptor activation reduces inhibitory postsynaptic potentials in hippocampal CA3 pyramidal cells of rat and guinea pig.
The Journal of pharmacology and experimental therapeutics. 252(3):1361-9 [PMID] 1969476.
1990
Stimulation of endogenous opioid release displaces mu receptor binding in rat hippocampus.
Neuroscience. 37(1):45-53 [PMID] 1978741.
1988
A novel interaction between dynorphin(1-13) and an N-methyl-D-aspartate site.
Brain research. 443(1-2):329-32 [PMID] 2896056.
1988
Influence of dynorphin (1-13) on spinal reflexes in the rat.
The Journal of pharmacology and experimental therapeutics. 246(2):508-13 [PMID] 2900326.
1987
Intrathecal dynorphin(1-13) results in an irreversible loss of the tail-flick reflex in rats.
Brain research. 435(1-2):1-6 [PMID] 2892573.

Grants

Jun 2024 ACTIVE
Role of Understudied aGPCRs in Orofacial Neuropathic Pain
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Sep 2022 ACTIVE
Innervation of the knee and TMJ
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Sep 2020 ACTIVE
Opioid and cannabinoid interactions in pain and reward
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
Nov 2019 – Apr 2020
Extension_IPA agreement-Jian Zuo
Role: Other
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Sep 2019 – Sep 2022
Therapeutic in situ analgesic implant for improved oral-facial post-operative pain outcomes
Role: Principal Investigator
Funding: EPIGEN BIOSCIENCES via NATL INST OF HLTH NIDCR
Jun 2019 – Jun 2024
Exploring neuropeptide guided botulinum light chain for use in blocking pain transmission
Role: Principal Investigator
Funding: UF FOUNDATION via FACIAL PAIN RESEARCH FOUNDATION
Dec 2018 – Jun 2019
Operant model testing of polymer system for facial incisional analgesia
Role: Principal Investigator
Funding: FRIEDMAN CONSULTING
Aug 2018 – Aug 2021
VA Contract-Animals for Qiqi Zhou (VA PI) Sprague Dawley Rats from Charles River
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Mar 2018 ACTIVE
OA Pathogenesis beyond Cartilage: A preclinical study of the sources of OA pain
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Nov 2017 – Oct 2019
IPA agreement-Jian Zou
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Jul 2017 – Jul 2020
IPA agreement-Robert Caudle
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Mar 2006 – May 2023
Davis Cancer Researach Equipment
Role: Project Manager
Funding: UF FOUNDATION

Contact Details

Phones:
Business:
(352) 273-6767
Emails:
Business:
caudle@ufl.edu
Addresses:
Business Mailing:
PO BOX 100416
D7-46
GAINESVILLE FL 326100416
Business Street:
DEPT. OF ORAL AND MAXILLOFACIAL SURGERY
PO BOX 100416
ROOM D7-46
GAINESVILLE FL 326100416