Sara N Burke

Sara N Burke

Associate Professor, Associate Director Cognitive Aging And Memory Center

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 294-4979
Business Email: burkes@ufl.edu

About Sara N Burke

Dr. Burke is an Associate Professor of Neuroscience and Associate Director of the Cognitive Aging and Memory Center (CAM) at the University of Florida College of Medicine. She received her PhD in Neuroscience & Pharmacology in 2009 from the University of Arizona and went on to complete a Postdoctoral Fellowship (2009-2013) at her alma mater. The overarching goals of her NIH-funded research program are to 1) pinpoint alterations in how different brain regions communicate over the lifespan and how this contributes to loss of function in advanced age, and 2) to design therapeutic strategies for alleviating cognitive dysfunction in order to promote positive health outcomes in the elderly.

Research Profile

Dr. Burke’s research pertains to investigating mechanisms of cognition and determining how diet and metabolic function can increase resilience to memory loss in aging and disease. To answer these questions, her lab integrates data across multiple levels of analysis that includes neurophysiology, gene expression, anatomy and behavioral assays. Using these integrative approaches, current projects in her laboratory are focused on uncovering mechanisms of age-related impairments in hippocampal-dependent sensory discrimination across modalities in normal aging and a novel model of tau pathology (Ed and Ethel Moore Alzheimer’s Disease Research Program), identifying age-associated changes in medial temporal lobe-prefrontal functional connectivity that contribute to memory deficits (1R01AG049722; 1R21AG051004), and testing whether diet can globally improve neural network function in old animals (pilot grant sub-award of P30AG028740). Her rationale is that by elucidating how aging influences systems-level dynamics, her lab will be better positioned to develop interventions that broadly improve cognition and everyday living.

Publications

Grants

Apr 2020 ACTIVE
Cyclic ketogenic therapy as treatment for Alzheimers disease-related metabolic decline, tau pathology and cognitive impairments
FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER · Principal Investigator
Feb 2019 ACTIVE
Metabolic Interventions for Enhancing Cognitive Resilience in Aging and Alzheimers Disease.
NATL INST OF HLTH NIA · Principal Investigator
Sep 2018 ACTIVE
Decision making and basolateral amygdala dysfunction in aging
NATL INST OF HLTH NIA ·
Apr 2018 ACTIVE
Hippocampal and dopaminergic?mechanisms of novelty detection underlying cognitive resilience in aging
NATL INST OF HLTH NIA · Mentor
Mar 2018 ACTIVE
Interactions of Perirhinal Tau Pathology and Aging in Cognitive Dysfunction
NATL INST OF HLTH NIA ·
Sep 2017 – Aug 2018
Metabolic Mechanisms for Treating Cognitive Aging
NATL INST OF HLTH NIA ·
Apr 2017 ACTIVE
Age-associated changes?in hippocampal circuits and cognitive function
NATL INST OF HLTH NIA ·
Jan 2017 – Mar 2019
The Impact of Perirhinal Cortical Tau Pathology on Pre-clinical Alzheimers Disease Cognitive Decline
FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER ·
Jan 2017 ACTIVE
Cognitive Augmentation through Neuroplasticity (CAN)
US DEPT OF DEFENSE DARPA ·
Sep 2016 ACTIVE
Testing and forecasting hippocampal theta wave propagation in learning and memory
NATL INST OF HLTH NIMH ·
Aug 2016 – May 2019
Single-Cell Imaging of Functional Connectivity as a Window into Cognitive Aging
NATL INST OF HLTH NIA · Principal Investigator
Apr 2016 – Mar 2017
AGE-ASSOCIATED FUNCTIONAL CONNECTIVITY DECLINES IN THE
UF ALZHEIMER'S DISEASE RESEARCH CENTER · Principal Investigator
Apr 2016 – Mar 2017
Claude D Pepper Older Americans Independence Center
NATL INST OF HLTH NIA · Project Manager
Jan 2016 ACTIVE
The contribution of declines in functional connectivity to cognitive aging
NATL INST OF HLTH NIA · Principal Investigator
Aug 2015 – May 2017
Neurogenesis and Memory Network Dynamics during Normal
NATL INST OF HLTH NIA · Principal Investigator
Apr 2015 – Mar 2016
Claude D. Pepper Older Americans Independence Center
NATL INST OF HLTH NIA · Project Manager
Jun 2014 – May 2016
Neurogenesis and memory dynamics during normal aging
UF DSR OPPORTUNITY FUND · Principal Investigator
Apr 2008 ACTIVE
Evelyn F. McKnight Brain Research Program in Age-Related Memory Loss.
MCKNIGHT FOU · Project Manager

Contact Details

Phones:
Business:
(352) 294-4979
Emails:
Business:
burkes@ufl.edu