David R Borchelt

David R Borchelt

Professor, Director SantaFe Health Alzheimer’s Disease Research Center

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 273-9664
Business Email: drb1@ufl.edu

About David R Borchelt

Dr. Borchelt is a Professor of Neuroscience at the University of Florida College of Medicine and Director of SantaFe Health Alzheimer’s Disease Research Center. He received his PhD in Microbiology/Virology in 1986 from the University of Kentucky and went on to complete a Postdoctoral Fellowship (1986-1989) at the University of California, San Francisco. His laboratory is committed to investigations designed to elucidate the molecular processes by which specific mutant proteins cause disease. This work involves the use of transgenic mouse models, knockout mice, and cell culture systems to examine the effect of mutations on the function and biology of the mutated proteins. Collectively, these approaches provide insight into the molecular mechanisms of disease and have the potential to identify new therapeutic strategies for these disorders.

Research Profile

Dr. Borchelt’s research is focused on defining the basic molecular events that underlie human neurodegenerative diseases, and using this information to develop new therapeutic strategies. To accomplish these goals, his lab uses a variety of model systems to understand how mutations in specific genes cause diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease. As they have begun to decipher the mechanisms of these diseases, his lab has found common features that implicate common pathways. One of the common features of these disorders is the presence of pathological structures in brain or spinal cord that are composed of misfolded proteins. Recent studies have revealed that the misfolded pathologic proteins in ALS and Alzheimer’s disease can exhibit prion-like properties to mediate the spread of pathology throughout the brain or spinal cord. His lab is currently focused on understanding the mechanisms by which pathology seems to spread in the nervous system and identify therapies to slow this spread.

Publications

2019 The Journal of neuroscience : the official journal of the Society for Neuroscience
2018 Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2018 The Journal of experimental medicine
2018 Biological psychiatry
2014 Translational research : the journal of laboratory and clinical medicine
2014 Proceedings of the National Academy of Sciences of the United States of America
2014 Journal of Huntington's disease
2013 The Journal of neuroscience : the official journal of the Society for Neuroscience
2013 The Journal of clinical investigation
2013 Molecular neurodegeneration
2009 Proceedings of the National Academy of Sciences of the United States of America
2009 Methods in molecular biology (Clifton, N.J.)
2009 Journal of the American Geriatrics Society
2009 Experimental biology and medicine (Maywood, N.J.)
2008 The Journal of neuroscience : the official journal of the Society for Neuroscience
2007 The Journal of neuroscience : the official journal of the Society for Neuroscience
2007 Journal of toxicology and environmental health. Part B, Critical reviews
2005 The Journal of neuroscience : the official journal of the Society for Neuroscience
2002 Journal of Alzheimer's disease : JAD
2000 Annals of the New York Academy of Sciences
1999 Philosophical transactions of the Royal Society of London. Series B, Biological sciences
1998 Nature genetics
1996 Current opinion in neurobiology
1996 Cold Spring Harbor symposia on quantitative biology
1996 Brain pathology (Zurich, Switzerland)
1994 Proceedings of the National Academy of Sciences of the United States of America
1993 Proceedings of the National Academy of Sciences of the United States of America
1992 Proceedings. Symposium on Computer Applications in Medical Care
1990 Proceedings of the National Academy of Sciences of the United States of America

Grants

Jan 2020 ACTIVE
Provenance Initiatives Fund: Towards the identification of new therapies for ALS
UF FOU · Principal Investigator
Sep 2019 ACTIVE
Developing new conditional models to study tauopathy, amyloidosis, and their interaction
NATL INST OF HLTH NINDS ·
Sep 2018 ACTIVE
Prion and non-prion induction mechanisms of alpha-synuclein pathology
NATL INST OF HLTH NINDS ·
Jun 2018 ACTIVE
APOE as a modifier of prion-like spread in dementia
NATL INST OF HLTH NIA · Principal Investigator
Sep 2017 – May 2018
APOE as a modifier of prion-like spread in dementia
NATL INST OF HLTH NIA · Principal Investigator
Aug 2017 – Apr 2019
New Drug Discovery Paradigms for Synucleinopathy
LANKENAU INSTITUTE FOR MEDICAL RESEARCH · Principal Investigator
Dec 2016 – Nov 2019
Is there a form of benign brain amyloidosis in aging?
NATL INST OF HLTH NIA · Principal Investigator
Aug 2016 – Sep 2019
New mouse models to dissect out the function of the ALS-associated protein Matrin 3
AMYOTROPHIC LATERAL SCLEROSIS ASSOC ·
Aug 2015 ACTIVE
University of Florida – Mt. Sinai Medical Center AD Research Center
NATL INST OF HLTH NIA ·
Jul 2015 ACTIVE
Modeling the progression of SOD1-linked motor neuron disease
NATL INST OF HLTH NINDS · Principal Investigator
Jun 2015 – Jun 2017
Inhibitors of SOD1 interaction as an approach to slow th
US ARMY MED RES ACQUISITION · Principal Investigator
Jun 2015 – May 2017
Role Misfolded Wild-Type SOD1 in Cases of Sporadic ALS
JOHNS HOPKINS UNIV · Principal Investigator
May 2015 ACTIVE
Proteostasis and secondary proteinopathy in AD and FTD
NATL INST OF HLTH NIA · Principal Investigator
May 2015 – Mar 2018
Seeded transmission of SOD1 misfolding
NATL INST OF HLTH NINDS · Principal Investigator
Jun 2014 – May 2017
Novel Therapeutics for activation of the antioxidant res
UF DSR OPPORTUNITY FUND · Principal Investigator
May 2014 – Feb 2017
Seeded models of AD pathology
NATL INST OF HLTH NIA · Principal Investigator
Jul 2008 ACTIVE
SFHC AD Research Center
UF FOU · Principal Investigator
Jul 2006 ACTIVE
BRAIN AND SPINAL CORD INJURY RESEARCH
FL DEPT OF HLTH · Project Manager

Contact Details

Phones:
Business:
(352) 273-9664
Emails:
Business:
drb1@ufl.edu