Karina Alviña

Karina Alviña,

Research Assistant Professor

Department: MD-NEUROSCIENCE-GENERAL
Business Phone: (352) 273-8865
Business Email: kalvina@ufl.edu

About Karina Alviña

Dr. Alviña is a Research Assistant Professor of Neuroscience at the University of Florida College of Medicine. She received her PhD in Biological Sciences-Physiology in 2008 from the Pontifical Catholic University of Chile in Santiago, Chile. She went on to complete her first Postdoctoral Fellowship (2009-2011) at Columbia University in New York, NY and a second Postdoctoral Fellowship (2012-2016) at the Albert Einstein College of Medicine in The Bronx, NY. Dr. Alviña’s work focuses on various aspects of fundamental cellular physiology in the brain. In particular, she studies how specific areas involved in learning and memory are influenced by environmental factors such as stress, exercise and dietary habits, and neurodegenerative conditions such as Alzheimer’s disease .

Research Profile

Dr. Alviña’s research program centers around understanding how brain cells communicate with each other to evoke different behaviors, in normal and pathological conditions. Areas of focus include neural mechanisms altered by stress and environmental factors such as dietary habits and exercise, and how these mechanisms can lead to unhealthy cognitive aging and neurodegenerative disorders such as Alzheimer’s disease. Dr. Alviña’s laboratory utilizes a multi-disciplinary approach that includes behavioral analysis using animals models, electrophysiology, and pharmacology.

Open Researcher and Contributor ID (ORCID)

0000-0002-8369-0953

Areas of Interest
  • Clinical Translational Neuroscience
  • Neurodegenerative diseases
  • Neurological disorders
  • Neurophysiology
  • Neuroplasticity
  • neuro-inflammation
  • neuroscience

Publications

2021
Altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice.
Scientific reports. 11(1) [DOI] 10.1038/s41598-021-87678-x. [PMID] 33863940.
2021
Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer.
European journal of medicinal chemistry. 209 [DOI] 10.1016/j.ejmech.2020.112866. [PMID] 33039722.
2021
Multiple Roles in Neuroprotection for the Exercise Derived Myokine Irisin.
Frontiers in aging neuroscience. 13 [DOI] 10.3389/fnagi.2021.649929. [PMID] 33935687.
2021
Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses.
eLife. 10 [DOI] 10.7554/eLife.66612. [PMID] 34061025.
2020
Hippocampal injection of the exercise-induced myokine irisin suppresses acute stress-induced neurobehavioral impairment in a sex-dependent manner.
Behavioral neuroscience. 134(3):233-247 [DOI] 10.1037/bne0000367. [PMID] 32437197.
2020
Long term effects of stress on hippocampal function: Emphasis on early life stress paradigms and potential involvement of neuropeptide Y.
Journal of neuroscience research. [DOI] 10.1002/jnr.24614. [PMID] 32162350.
2019
Maternal elevated salt consumption and the development of autism spectrum disorder in the offspring.
Journal of neuroinflammation. 16(1) [DOI] 10.1186/s12974-019-1666-2. [PMID] 31837704.
2019
The role of inflammation and the gut microbiome in depression and anxiety.
Journal of neuroscience research. 97(10):1223-1241 [DOI] 10.1002/jnr.24476. [PMID] 31144383.
2018
Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis.
Neuroscience. 369:192-201 [DOI] 10.1016/j.neuroscience.2017.11.017. [PMID] 29155277.
2018
Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation.
Neuron. 97(5):1137-1152.e5 [DOI] 10.1016/j.neuron.2018.01.026. [PMID] 29429933.
2017
Diversity of Graduates from Bachelor’s, Master’s and Doctoral Degree Neuroscience Programs in the United States.
Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience. 16(1):A6-A13 [PMID] 29371835.
View on: PubMed
2016
Developmental change in the contribution of voltage-gated Ca(2+) channels to the pacemaking of deep cerebellar nuclei neurons.
Neuroscience. 322:171-7 [DOI] 10.1016/j.neuroscience.2016.02.031. [PMID] 26902515.
2015
A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.
Cell reports. 12(3):396-404 [DOI] 10.1016/j.celrep.2015.06.037. [PMID] 26166572.
2014
A temporal basis for predicting the sensory consequences of motor commands in an electric fish.
Nature neuroscience. 17(3):416-22 [DOI] 10.1038/nn.3650. [PMID] 24531306.
2014
Sensory processing and corollary discharge effects in posterior caudal lobe Purkinje cells in a weakly electric mormyrid fish.
Journal of neurophysiology. 112(2):328-39 [DOI] 10.1152/jn.00016.2014. [PMID] 24790163.
2010
KCa channels as therapeutic targets in episodic ataxia type-2.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(21):7249-57 [DOI] 10.1523/JNEUROSCI.6341-09.2010. [PMID] 20505091.
2010
The therapeutic mode of action of 4-aminopyridine in cerebellar ataxia.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(21):7258-68 [DOI] 10.1523/JNEUROSCI.3582-09.2010. [PMID] 20505092.
2009
T-type calcium channels mediate rebound firing in intact deep cerebellar neurons.
Neuroscience. 158(2):635-41 [DOI] 10.1016/j.neuroscience.2008.09.052. [PMID] 18983899.
2008
Questioning the role of rebound firing in the cerebellum.
Nature neuroscience. 11(11):1256-8 [DOI] 10.1038/nn.2195. [PMID] 18820695.
2008
Selective regulation of spontaneous activity of neurons of the deep cerebellar nuclei by N-type calcium channels in juvenile rats.
The Journal of physiology. 586(10):2523-38 [DOI] 10.1113/jphysiol.2007.148197. [PMID] 18372310.
2006
Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia.
Nature neuroscience. 9(3):389-97 [PMID] 16474392.
View on: PubMed
2004
Histamine reduces gap junctional communication of human tonsil high endothelial cells in culture.
Microvascular research. 68(3):247-57 [PMID] 15501244.
View on: PubMed

Grants

Apr 2021 ACTIVE
Role of Irisin as mediator of exercise-related cognitive improvement in Alzheimers Disease
Role: Principal Investigator
Funding: FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Apr 2021 ACTIVE
Centrifugal regulation of olfactory function by melanin-concentrating hormone
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCD

Education

Postdoctoral Fellow
2012-2016 · Albert Einstein College of Medicine
Postdoctoral Fellow
2009-2011 · Columbia University
Ph.D. Biological Sciences, Physiology
2008 · Pontifical Catholic University of Chile

Teaching Profile

Courses Taught
2020
GMS7794 Neuroscience Seminar
2021
GMS6705 Functional Human Neuroanatomy

Contact Details

Phones:
Business:
(352) 273-8865
Emails:
Business:
kalvina@ufl.edu