Jose F Abisambra

Jose F Abisambra

Associate Professor, Program Co-Director MS In Neuroscience Graduate Program

Department: MD-NEUROSCIENCE-GENERAL
Business Email: j.abisambra@ufl.edu

About Jose F Abisambra

Dr. Abisambra is an Associate Professor of Neuroscience and Assistant Dean of Diversity & Health Equity at the University of Florida College of Medicine. He received his PhD in Medical Sciences/Molecular Medicine in 2010 from the University of South Florida and went on to complete a Postdoctoral Fellowship (2010-2012) at his alma mater. The overarching goal of his research program is to investigate the molecular mechanisms linking tau and ER dysfunction with neurodegeneration. This focus creates an opportunity to investigate the integration of essential cellular functions for development, aging, and disease by targeting one organelle. Ultimately, this work can aid in the identification of therapeutic targets for more than 30 million people currently suffering from tauopathies worldwide.

Research Profile

Dr. Abisambra’s research pertains to investigating fundamental biological processes critical to neuronal function that converge with endoplasmic reticulum (ER) proteins. His lab’s currently supported projects focus on the impact of the Unfolded Protein Response on neurodegenerative processes in Alzheimer’s and related proteinopathies. His work explores protein synthesis (Meier et al., 2016), trafficking (mitochondria, Golgi apparatus, plasma membrane, etc.) (Jinwal et al., 2010), folding (Abisambra et al., 2012; Abisambra et al., 2013a), and clearance (proteasome and autophagy) (Abisambra et al., 2013b) as fundamental processes during brain development, aging, and stress. He further investigates the impact of the ER on calcium homeostasis and lipid/carbohydrate metabolism (Abisambra et al., 2010) in the context of whole neuronal function. Alterations to these processes are linked to the pathogenesis of 25 known neurodegenerative disorders that share a common pathological hallmark: intracellular aggregation of tau. These tauopathies include Alzheimer’s disease (AD), chronic traumatic encephalopathy/traumatic brain injury (CTE/TBI; reviewed in (Abisambra and Scheff, 2014), and fronto-temporal degeneration with tau inclusions (FTD-tau).

Open Researcher and Contributor ID (ORCID)

0000-0001-6341-679X

Publications

2019 International journal of molecular sciences
2016 The Journal of neuroscience : the official journal of the Society for Neuroscience
2014 Journal of Alzheimer's disease : JAD
2013 FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2013 The Journal of neuroscience : the official journal of the Society for Neuroscience
2011 The Journal of neuroscience : the official journal of the Society for Neuroscience
2010 The Journal of biological chemistry
2010 The Journal of neuroscience : the official journal of the Society for Neuroscience
2010 The Journal of neuroscience : the official journal of the Society for Neuroscience

Grants

Sep 2019 ACTIVE
Developing new conditional models to study tauopathy, amyloidosis, and their interaction
NATL INST OF HLTH NINDS ·
Sep 2019 ACTIVE
Tau-mediated regulation of ribosomes in health and disease
NATL INST OF HLTH NINDS · Principal Investigator
Aug 2019 ACTIVE
Exosomes from Adipose-derived Stem Cells Modulate Age-dependent Progression of Tauopathies
UNIV OF SOUTH FLORIDA · Principal Investigator
Sep 2018 – Sep 2019
The impact of PERK on Post-traumatic Tauopathy in Alzheimers Disease
UNIV OF KENTUCKY · Principal Investigator
Sep 2018 ACTIVE
PERK as a Central Mediator of Neurotoxicity in Tauopathies
NATL INST OF HLTH NINDS · Principal Investigator
Jul 2018 ACTIVE
Elucidating the pathological consequences of tau-ribosome interactions
NATL INST OF HLTH NINDS · Principal Investigator
Jul 2018 – Jun 2019
Myocardial Tauopathy: A New Pathogenesis and Treatment for Heart Disease
MEDICAL UNIV OF SOUTH CAROLINA · Principal Investigator
Aug 2015 – Jul 2020
Molecular clock and skeletal muscle weakness
NATL INST OF HLTH NIAMS · Project Manager

Contact Details

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