Some hormone, cytokine and chemokine levels that change across lifespan vary by cognitive status in male Fischer 344 rats. Scheinert RB, Asokan A, Rani A, Kumar A, Foster TC, Ormerod BK. Brain Behav Immun 2015. Abstract: We trained and tested young (6-8 mo; n = 13), middle-aged…
Parallel Evolution and Lineage-Specific Expansion of RNA Editing in Ctenophores. Kohn AB, Sanford RS, Yoshida MA, Moroz LL. Integr Comp Biol 2015. Abstract: RNA editing is a process of targeted alterations of nucleotides in all types of RNA molecules (e.g., rRNA, tRNA, mRNA, and miRNA). As a…
Behavioral abnormalities in APP/PS1dE9 mouse model of AD-like pathology: comparative analysis across multiple behavioral domains. Janus C, Flores AY, Xu G, Borchelt DR. Neurobiol Aging 2015. Abstract: Alzheimer’s disease (AD) is characterized by dysfunction in cognitive and noncognitive domains with clinical diagnosis based on multiple neuropsychological tests.
Molecular aspects of age-related cognitive decline: the role of GABA signaling. McQuail JA, Frazier CJ, Bizon JL. Trends Mol Med 2015. Abstract: Alterations in inhibitory interneurons contribute to cognitive deficits associated with several psychiatric and neurological diseases. Phasic and tonic inhibition imparted by γ-aminobutyric acid…
Investigation of the subcellular architecture of L7 neurons of Aplysia californica using magnetic resonance microscopy (MRM) at 7.8 microns. Lee CH, Flint JJ, Hansen B, Blackband SJ. Sci Rep 2015; 5:11147. Abstract: Magnetic resonance microscopy (MRM) is a non-invasive diagnostic tool which is well-suited to directly resolve…
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Dopamine Transporter Activity Is Modulated by alpha-synuclein. Butler B, Goodwin S, Saha K, Becker J, Sambo D, Davari P, Khoshbouei H. J Biol Chem 2015. Abstract: The duration and strength of the dopaminergic signal is regulated by the dopamine transporter (DAT). Drug addiction, neurodegenerative and neuropsychiatric diseases…
Differential Inhibition of Signal Peptide Peptidase Family Members by Established gamma-Secretase Inhibitors. Ran Y, Ladd GZ, Ceballos-Diaz C, Jung JI, Greenbaum D, Felsenstein KM, Golde TE. PLoS One 2015; 10(6):e0128619. Abstract: The signal peptide peptidases (SPPs) are biomedically important proteases implicated as therapeutic targets for hepatitis C…
Characterization of Protein Structural Changes in Living Cells Using Time-Lapsed FTIR Imaging. Gelfand P, Smith RJ, Stavitski E, Borchelt DR, Miller LM. Anal Chem 2015. Abstract: Fourier-transform infrared (FTIR) spectroscopic imaging is a widely used method for studying the chemistry of proteins, lipids, and DNA in…
Substantially elevating the levels of alphaB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation. Xu G, Fromholt S, Ayers JI, Brown H, Siemienski Z, Crosby KW, Mayer CA, Janus C, Borchelt DR. J Neurochem 2015; 133(3):452-464. Abstract:…
