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Dr. Todd Golde & colleagues publish in Dec 17, 2015 PLOS One

gamma-Secretase Modulators and APH1 Isoforms Modulate gamma-Secretase Cleavage but Not Position of epsilon-Cleavage of the Amyloid Precursor Protein (APP). Lessard CB, Cottrell BA, Maruyama H, Suresh S, Golde TE, Koo EH. PLoS One 2015; 10(12):e0144758. Abstract: The relative increase in Aβ42 peptides from familial Alzheimer disease (FAD)…

Dr. Leonid Moroz publishes in December 2015 Integrative & Comparative Biology

Biodiversity Meets Neuroscience: From the Sequencing Ship (Ship-Seq) to Deciphering Parallel Evolution of Neural Systems in Omic’s Era. Moroz LL. Integr Comp Biol 2015; 55(6):1005-1017. Abstract: The origins of neural systems and centralized brains are one of the major transitions in evolution. These events might occur more…

Dr. Jeremy Flint & colleagues publish in Dec 2015 Scientific Reports

A Microperfusion and In-Bore Oxygenator System Designed for Magnetic Resonance Microscopy Studies on Living Tissue Explants. Flint JJ, Menon K, Hansen B, Forder J, Blackband SJ. Sci Rep 2015; 5:18095. Abstract: Spectrometers now offer the field strengths necessary to visualize mammalian cells but were not designed to…

Dr. Leonid Moroz publishes in Dec 2015 Integrative & Comparative Biology

Unbiased View of Synaptic and Neuronal Gene Complement in Ctenophores: Are There Pan-neuronal and Pan-synaptic Genes across Metazoa? Moroz LL, Kohn AB. Integr Comp Biol 2015; 55(6):1028-1049. Abstract: Hypotheses of origins and evolution of neurons and synapses are controversial, mostly due to limited comparative data. Here, we…

Graduate Student, Caleb Bostwick, Dr. Leonid Moroz & colleagues publish in Dec 14, 2016 PNAS

Hyperpolarization-activated, cyclic nucleotide-gated cation channels in Aplysia: Contribution to classical conditioning. Yang Q, Kuzyk P, Antonov I, Bostwick CJ, Kohn AB, Moroz LL, Hawkins RD. Proc Natl Acad Sci U S A 2015. Abstract: Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels are critical regulators of neuronal excitability, but…

Dr. Paul Reier & colleagues publish in Dec 10, 2015 Muscle & Nerve

Forelimb Muscle Plasticity Following Unilateral Cervical Spinal Cord Injury. Gonzalez-Rothi EJ, Armstrong GT, Cerreta AJ, Fitzpatrick GM, Reier PJ, Lane MA, Judge AR, Fuller DD. Muscle Nerve 2015. ABSTRACT: INTRODUCTION:  Motor dysfunction and muscle atrophy are well-documented in the lower extremity following spinal cord injury. However the…

Dr. Jacob Ayers & Borchelt lab publish in Dec 9, 2015 Acta Neuropathologica

Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways. Ayers JI, Fromholt SE, O’Neal VM, Diamond JH, Borchelt DR. Acta Neuropathol 2015. Abstract: A hallmark feature of amyotrophic lateral sclerosis (ALS) is that symptoms appear to spread along neuroanatomical pathways to engulf…