Jeremy C. McIntyre, Ph.D.
Department of Neuroscience
University of Florida
1149 Newell Drive, PO Box 100244
Gainesville, FL 32611-0244
Office Phone: (352) 294-8266
Lab Phone: (352) 273-9018
Lab Website: http://www.jmcintyrelab.org/
|2009||Ph.D. (Physiology)||University of Kentucky, Lexington, KY|
|2009-2013||Postdoctoral Fellow (Pharmacology)||University of Michigan, Ann Arbor, MI|
|2014-2015||Postdoctoral Associate (Pharmacology)||University of Florida, Gainesville, FL|
Key Words: Olfaction, Anosmia, Channelopathy, Gene therapy, Neuronal cilia, neuromodulation, G-protein Coupled Receptors
Research Summary & Focus:
The McIntyre Lab is broadly interested in the molecular mechanisms that underlie olfactory function. We study both the sensory neurons in the nasal cavity that detect odors in the environment as well as the neurons in the olfactory bulb that begin the neural processing of this information. The lab currently has several ongoing projects.
First, we are applying gene therapy approaches to correct congenital defects in the sense of smell. Currently we are focused on mutations affecting ion channel function. We are developing methods to delivery and re-express functional copies of these channels to the olfactory epithelium to restore olfactory function. To evaluate the effectiveness of these therapies we used immunofluorescence, calcium imaging, electrophysiology and behavioral experiments.
In the olfactory bulb, we are studying how physiological conditions affects odor processing. Input into the olfactory bulb from higher regions of the brain are known to modulate how neurons in the bulb respond to odors, making them more or less responsive. We are investigating neuromodulators involved in hunger/satiety signaling and those that change with aging. Our work focuses on several GPCRs involved in these signaling pathways that localize to the primary cilia that project from neuronal cell bodies. Cilia are critical for cellular function, and disruptions of cilia function can lead to numerous disease phenotypes. The lab is working to further understand the role of cilia in integrating a variety of signals and the modulation of neuronal processes. To achieve these goals, we have developed several new mouse models to look at cell specific ablation of cilia and immunofluorescence and confocal microscopy, calcium imaging, electrophysiology, molecular biology and behavior.