Eduardo Candelario-Jalil, Ph.D.
Department of Neuroscience
University of Florida
1149 Newell Drive
PO Box 100244
Gainesville, FL 32611-0244
Office Phone: (352) 273-7116
Lab Phone: (352) 273-6764
Lab Members: Candelario-Jalil Lab
|University of Havana
|University of Freiburg Medical School
|University of Mexico
Key Words: Ischemic Stroke, Neuroinflammation, Blood-Brain Barrier, Matrix Metalloproteinases, Cerebral Ischemia, Neurovascular Injury
Our research is aimed at understanding how neuroinflammatory mechanisms contribute to ischemic stroke pathology with a specific emphasis on the blood-brain barrier (BBB). Neurovascular/BBB damage is a key neuropathological mechanism in stroke, which significantly contributes to brain edema, neurological deterioration, and death in stroke patients. We are interested in cyclooxygenase-2-derived prostaglandins and how signaling through specific prostanoid receptors impact stroke outcomes. We are also studying the neurovascular effects of adropin, a newly identified peptide, on BBB damage after stroke. We expect that results from our research will identify novel and much-needed therapeutic approaches to reduce the devastating consequences of stroke-induced BBB damage.