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Read the latest from the Golde Group

  Large-scale protein analysis of Alzheimer’s disease (AD) in the brain and cerebrospinal fluid reveals new associations with early changes in energy metabolism, according to research from UF Golde group of neuroscientists. Findings revealed these early changes in energy metabolism to be associated with microglia and astrocyte activation. Because the…

Spatial cognition and the hippocampus: neuroscientists weigh in

In a new perspective piece in the journal Trends in Cognitive Sciences, UF neuroscientist Andrew Mauerer, Ph.D., and University of psychologist Lynn Nadel, Ph.D., highlight the role of the hippocampus in spatial cognition and episodic memory. Andrew Maurer, Ph.D. (center). [This image was taken prior to national guidelines of…

Read the latest from Streit and Colleagues

 UF Neuroscientists look deeper into dystrophic microglia in late-onset Alzheimer’s disease (AD). Studies conducted were done so by neuropathological analysis of post-mortem human brains with special attention paid to microglia, as these cells are important in cellular processes that lead to AD-type neurodegeneration. After finding an in situ correlation between…

Read the latest from Tansey and colleagues

Neuroscientists from University of Florida investigate plasma proteins’ influence on peripheral and central inflammation in depression. Peripheral blood C-reactive protein (CRP) is a biomarker used clinically to measure systemic inflammation. Patients with major depressive disorder (MDD) show increased amounts of CRP. Increased peripheral blood CRP in MDD has been associated…

Read the latest from the Khoshbouei Group

University of Florida neuroscientists make breakthroughs in research regarding Parkinson’s disease (PD) in rodent model. The findings indicate both dopamine neuron loss protection and improved motor deficits due to alterations with gut microbiota and antibiotics. With PD affecting approximately 10 million worldwide with degeneration of motor and non-motor…

Read the Latest from Khoshbouei Group

New study from the University of Florida Department of Neuroscience finds anti-inflammatory agents do not yield beneficial effects in treating addiction disorders. Methamphetamine (METH), a psychostimulant subject to abuse worldwide, is widely recognized for its effects on dopamine neurotransmission and the central nervous system (CNS). In recent years, questions of…

Read the latest from the Borchelt Group

Drs. Jake Ayres and Dave Borchelt publish a new review in Acta Neuropathologica on phenotypic diversity in amyotrophic lateral sclerosis (ALS).  In many types of familial amyotrophic lateral sclerosis (fALS), mutations…

Read the Latest from the Tansey Group

Drs. Malu Tansey and Rebecca Wallings publish a new review in Biochemical Society Transactions that  reviews the role of LRRK2 mutation in pathway regulation in immune cells. Drawing upon data from multiple diseases associated with LRRK2, they highlight the pleiotropic effects of LRRK2 in different cell types. They further role…

Read the latest from the Foster group

A new study by UF neuroscientists demonstrates an example of the brain’s ability to shift and utilize different neural circuits to perform a task in order to compensate for brain aging. The rat model study, published recently in the Journal of Neuroscience, was designed to test the hypothesis that cognitive…