“Meal frequency and timing in health and disease.” Mattson MP, Allison DB, Fontana L, Harvie M, Longo VD, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FA, Seyfried TN, Varady KA, Panda S. Proc Natl Acad Sci U S A 2014.
Ofori E, Pasternak O, Planetta PJ, Burciu R, Snyder A, Febo M, Golde TE, Okun MS, Vaillancourt DE. Increased free water in the substantia nigra of Parkinson’s disease: a single-site and multi-site study. Neurobiol Aging 2014. http://www.ncbi.nlm.nih.gov/pubmed/25467638?dopt=Citation Abstract: Measures from diffusion magnetic resonance imaging reflect…
“Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and gamma-Secretase Processivity”. Jung JI, Premraj S, Cruz PE, Ladd TB, Kwak Y, Koo EH, Felsenstein KM, Golde TE, Ran Y. PLoS One 2014; 9(10):e111553. Abstract Altered production of β-amyloid (Aβ) from the amyloid precursor protein (APP) is…
Borchelt DR, Ross CA. J Huntingtons Dis 2014; 3(3):225-227. PMID: 25300326 …
“Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice.” Xu G, Ayers JI, Roberts BL, Brown H, Fromholt S, Green C, Borchelt DR. Hum Mol Genet. 2014 Oct 9 [Epub ahead of print] PMID: 25305079…
“Understanding the role of progranulin in Alzheimer’s disease.” D’Alton S, Lewis J. Nat Med 2014; 20(10):1099-1100. PMID: 25295938 http://www.nature.com/nm/journal/v20/n10/full/nm.3712.html Alzheimer’s disease is characterized by severe cognitive decline and brain amyloid plaques. A new study in mouse models that develop features of Alzheimer’s disease indicates…
“Intracerebroventricular Viral Injection of the Neonatal Mouse Brain for Persistent and Widespread Neuronal Transduction.” Kim JY, Grunke SD, Levites Y, Golde TE, Jankowsky JL. J Vis Exp. 2014 Sep 15;(91). PMID: 25286085 http://www.ncbi.nlm.nih.gov/pubmed/25286085?dopt=Citation Abstract With the pace of scientific advancement accelerating rapidly, new methods…
“Experimental transmissibility of mutant SOD1 motor neuron disease.” Ayers JI, Fromholt S, Koch M, DeBosier A, McMahon B, Xu G, Borchelt DR. Acta Neuropathol 2014. http://www.ncbi.nlm.nih.gov/pubmed/25262000?dopt=Citation Abstract By unknown mechanisms, the symptoms of amyotrophic lateral sclerosis (ALS) seem to spread along neuroanatomical pathways to engulf…
“Endothelin-1-mediated vasoconstriction alters cerebral gene expression in iron homeostasis and eicosanoid metabolism.” Bickford JS, Ali NF, Nick JA, Al Yahia M, Beachy DE, Dore S, Nick HS, Waters MF. Brain Res 2014. http://www.ncbi.nlm.nih.gov/pubmed/25230250?dopt=Citation Abstract Endothelins are potent vasoconstrictors and signaling molecules. Their effects are broad,…
