UF Neuroscientists look deeper into dystrophic microglia in late-onset Alzheimer’s disease (AD).
Studies conducted were done so by neuropathological analysis of post-mortem human brains with special attention paid to microglia, as these cells are important in cellular processes that lead to AD-type neurodegeneration.
After finding an in situ correlation between microglial dystrophy and presence of NFD, scientists found suggestions that neurodegeneration is secondary to aging-related microglial deterioration. This idea builds on the concept that proper neuronal function is dependent on healthy microglia.
“Diseased or weakened glia are detrimental for neuronal well-being because their ability to provide neuronal support may be impaired.”
Recent work by scientists involved in the research shows chronic and weak microglial reaction contributing to an ongoing aging-dependent microglial deterioration. “An eventual total loss of functional microglia in advanced LOAD promotes widespread NFD, dementia, and brain failure.”