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UF Neuroscientists look deeper into dystrophic microglia in late-onset Alzheimer’s disease (AD).

Studies conducted were done so by neuropathological analysis of post-mortem human brains with special attention paid to microglia, as these cells are important in cellular processes that lead to AD-type neurodegeneration.

After finding an in situ correlation between microglial dystrophy and presence of NFD, scientists found suggestions that neurodegeneration is secondary to aging-related microglial deterioration. This idea builds on the concept that proper neuronal function is dependent on healthy microglia.

“Diseased or weakened glia are detrimental for neuronal well-being because their ability to provide neuronal support may be impaired.”

Recent work by scientists involved in the research shows chronic and weak microglial reaction contributing to an ongoing aging-dependent microglial deterioration. “An eventual total loss of functional microglia in advanced LOAD promotes widespread NFD, dementia, and brain failure.”

Read full paper in PubMed.