Sumners C, Isenberg J, Harmel A, Candelario-Jalil E, Steckelings U, Bennion D. OS 32-03 ANGIOTENSIN II TYPE 2 RECEPTOR AGONIST EXERTS SUSTAINED NEUROPROTECTIVE EFFECTS IN AGED RATS. J Hypertens 2016; 34 Suppl 1:e390.
The renin angiotensin system is a promising target for stroke neuroprotection and therapy through activation of angiotensin type II receptors (AT2R). The selective non-peptide AT2R agonist, Compound 21 (C21), has been shown to exhibit neuroprotection and improve stroke outcomes in preclinical studies, effects that likely involve neurotropic actions. However, these beneficial actions of C21 have not been demonstrated to occur beyond 1 week post stroke. The objective of this study was to determine if systemic administration of C21 would exert sustained neuroprotective effects in aged rats.