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Dr. Jada Lewis and colleagues publish in June 18, 2015 RNA
Studies of alternative isoforms provide insight into TDP-43 autoregulation and pathogenesis. D’Alton S, Altshuler M, Lewis J. RNA 2015. Abstract: TDP-43 is a soluble, nuclear protein that undergoes cytoplasmic redistribution and aggregation in the majority of cases of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 autoregulates…
Graduate Student, Matthew Hamm & colleagues publish in June 30, 2015 Journal of Neuroscience Research
Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2. Hamm M, Bailey R, Shaw G, Yen SH, Lewis J, Giasson BI. J Neurosci Res 2015. Abstract: Hyperphosphorylation and aggregation of tau are observed in multiple neurodegenerative diseases termed tauopathies. Tau has also been implicated in…
Graduate Student, Nicola Rutherford & Dr. Ben Giasson publish in June 15, 2015 Neuroscience Letter
The A53E alpha-synuclein pathological mutation demonstrates reduced aggregation propensity in vitro and in cell culture. Rutherford NJ, Giasson BI. Neurosci Lett 2015; 597:43-48. Abstract: Mutations in the gene that encodes α-synuclein (αS) are a known cause of Parkinson’s disease. αS is also the major component of pathological…
Dr. Leonid Moroz & colleagues publish in June 23, 2015 Journal of Comparative Neurology
Development of Neuromuscular Organization in the ctenophore Pleurobrachia bachei. Norekian TP, Moroz LL. J Comp Neurol 2015. Abstract: The phylogenetic position of the phylum Ctenophora and the nature of their nervous systems are highly debated topics in modern evolutionary biology. However, very little is known about the…
Dr. Tom Foster & colleagues publish in June 17, 2015 Brain, Behavior & Immunity
Some hormone, cytokine and chemokine levels that change across lifespan vary by cognitive status in male Fischer 344 rats. Scheinert RB, Asokan A, Rani A, Kumar A, Foster TC, Ormerod BK. Brain Behav Immun 2015. Abstract: We trained and tested young (6-8 mo; n = 13), middle-aged…
Dr. Leonid Moroz & colleagues publish in June 18, 2015 Integrative & Comparative Biology
Parallel Evolution and Lineage-Specific Expansion of RNA Editing in Ctenophores. Kohn AB, Sanford RS, Yoshida MA, Moroz LL. Integr Comp Biol 2015. Abstract: RNA editing is a process of targeted alterations of nucleotides in all types of RNA molecules (e.g., rRNA, tRNA, mRNA, and miRNA). As a…
Dr. Chris Janus & colleagues publish in May 21, 2015 Neurobiology of Aging
Behavioral abnormalities in APP/PS1dE9 mouse model of AD-like pathology: comparative analysis across multiple behavioral domains. Janus C, Flores AY, Xu G, Borchelt DR. Neurobiol Aging 2015. Abstract: Alzheimer’s disease (AD) is characterized by dysfunction in cognitive and noncognitive domains with clinical diagnosis based on multiple neuropsychological tests.
Dr. Joseph McQuail & colleagues publish in June 9, 2015 Trends in Molecular Medicine
Molecular aspects of age-related cognitive decline: the role of GABA signaling. McQuail JA, Frazier CJ, Bizon JL. Trends Mol Med 2015. Abstract: Alterations in inhibitory interneurons contribute to cognitive deficits associated with several psychiatric and neurological diseases. Phasic and tonic inhibition imparted by γ-aminobutyric acid…
Dr. Choong Lee, Blackband lab & colleagues publish in June 2015 Scientific Reports
Investigation of the subcellular architecture of L7 neurons of Aplysia californica using magnetic resonance microscopy (MRM) at 7.8 microns. Lee CH, Flint JJ, Hansen B, Blackband SJ. Sci Rep 2015; 5:11147. Abstract: Magnetic resonance microscopy (MRM) is a non-invasive diagnostic tool which is well-suited to directly resolve…