Yong Ran, M.D., Ph.D.

Ran, YongAssistant Scientist

Department of Neuroscience
Center for Translational Research in Neurodegenerative (CTRND)
1275 Center Drive
PO Box 100159
Gainesville, FL  32610-0159
Email:  yran@ufl.edu
Office phone: (352) 273-9690
Website:  Ran Research

Education:

1993-2001 M.D. Tongji Medical University
Wuhan, China
2001-2005 Ph.D.
(Bioengineering/Biophysics)
Huazhong University of Science & Technology
Wuhan, China
2005-2006 Postdoctoral Associate
(Physiology & Functional Genomics)
Department of Pysiology & Functional Genomics
University of Florida
Gainesville, Florida
2006-2011 Postdoctoral Associate
(Chemistry)
Department of Chemistry
University of Florida
Gainesville, Florida
2011-2012 Postdoctoral Associate
(Neuroscience)
Department of Neuroscience
Center for Translational Research in Neurodegenerative Disease (CTRND)
University of Florida
Gainesville, Florida

Key Words: Gamma-secretase, signal peptide peptidase, intramembrane proteolysis

Research Summary:

Our research focused on the cleavage mechanism of gamma secretase, signal peptide peptidase (SPP) and signal peptide peptidase like proteins (SPPLs). We have established a multi-substrate cleavage monitoring platform based on cell models and in vitro assay systems. This platform can help us to gain a better understanding of how gamma secretase works and how it reacts to various types of inhibitors and modulators. For the SPP and SPPLs project, we are working establish an accelerated screening method.  These methods enable us to comprehensively and efficiently screen for drugs active against gamma secretase and SPP in a fraction of the time used in current gamma secretase activity assays.
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