Habibeh Khoshbouei, Ph.D.

Habibeh Khoshbouei

Associate Professor

Office Phone:  (352) 273-8115
Lab Phone:     (352) 294-0105
Email:              habibeh@ufl.edu
Website:    https://sites.google.com/site/khoshboueilab

 Education:
1989    Pharm.D. Univ of Tehran, Iran School of Pharmacy
2001    Ph.D. Univ of Texas, San Antonio 

 

Research Summary:

The overall goal of my research program is to understand how the dopamine transporter (DAT) regulates biological responses, and how this regulation is modulated by structural differences in ligands acting at DAT and by DAT-interacting proteins. As an example, by discovering the mechanisms by which the DAT ligand methamphetamine induces its unique addictive qualities, we will not only reveal novel therapeutic targets for intervention/prophylaxis of disorders associated with dysregulation of the dopaminergic system, but almost certainly ascertain new molecular mechanisms for transporter-effected signal transduction. Finally, I also intend that my research laboratory will provide an outstanding venue for the training of doctoral and postdoctoral trainees.

Recent or Most Significant Publications:

Swant J, Chirwa S, Stanwood G, Khoshbouei H. Methamphetamine reduces LTP and increases baseline synaptic transmission in the CA1 region of mouse hippocampus. PLoS One 2010; 5(6):e11382.PM:20614033

Swant J, Goodwin JS, North A, Ali AA, Gamble-George J, Chirwa S, Khoshbouei H. alpha-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter. J Biol Chem 2011; 286(51):43933-43943.PM:21990355

Li Z, Chadalapaka G, Ramesh A, Khoshbouei H, Maguire M, Safe S, Rhoades RE, Clark R, Jules G, McCallister M, Aschner M, Hood DB. PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene. Toxicol Sci 2012; 125(1):233-247.PM:21987461

Li Z, Chadalapaka G, Ramesh A, Khoshbouei H, Maguire M, Safe S, Rhoades RE, Clark R, Jules G, McCallister M, Aschner M, Hood DB. PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene. Toxicol Sci 2012; 125(1):233-247.PM:21987461

North A, Swant J, Salvatore MF, Gamble-George J, Prins P, Butler B, Mittal MK, Hasting R, Clark JT, Khoshbouei H. Chronic methamphetamine exposure produces a delayed, long-lasting memory deficit. Synapse 2012.PM:23280858

Saha K, Swant J, Khoshbouei H. Single cell measurement of dopamine release with simultaneous voltage-clamp and amperometry. J Vis Exp 2012;(69).PM:23207721

Roth JA, Li Z, Sridhar S, Khoshbouei H. The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells. Neurotoxicology 2013.PM:23313730

PubMed