Kaustuv Saha, Ph.D.
Department of Neuroscience
University of Florida
1149 Newell Drive
PO Box 100244
Gainesville, FL 32611-0244
Lab Phone: (352) 273-8739
|2001||Bachelor in Pharmacy||Delhi Institute of Pharmaceutical Science and Research
University of Delhi, India.
|2004||Masters in Pharmacy
|Faculty of Pharmacy
Hamdard University, India
|2011||PhD (Pharmacology)||Department of Pharmacological and Pharmaceutical Sciences
College of Pharmacy, University of Houston, Texas
(Mentor: Dr. Habibeh Khoshbouei)
|Department of Neuroscience
University of Florida, Gainesville, Florida
The long-term goal of my research is to understand the pathophysiology and identify novel pharmacological approaches to stop or slow down rate of dopamine neuronal dysfunctions that is implicated in various neurological and neuropsychiatric disorders such as Parkinson’s disease and drug addiction. With an undergraduate degree in pharmacy and a doctoral degree in Pharmacology, I have developed a very strong interest in pursuing a career in research and target specific drug development. Following my PhD from University of Houston, Texas, I joined the laboratory of Dr. Habibeh Khoshbouei at the University of Florida. Using a multitude of approaches like single-cell / single-neuron / slice electrophysiology, amperometry, optogenetics, TIRF and confocal microscopy and rodent behavior, we study the underlying mechanisms involved in the pathophysiology of dopamine system and explore potential strategies to fix them. Over the past five years, my research has focused on determining how alpha-synuclein and drugs of abuse like methamphetamine and amphetamine modulate dopamine neuronal activities by modulating activities and trafficking of biogenic amine transporters and G-protein coupled receptors (GPCRs). My work revealed that overexpression of alpha synuclein, a synaptic protein implicated in neurodegenerative diseases, affect dopamine transmission prior to neuronal demise. Furthermore, the results of my work have provided mechanistic insight on how drugs of abuse like methamphetamine modulate dopamine neuronal activity to fuel their devastating addictive potential.