Jeremy Flint, Ph.D.

Jeremy FlintAssistant Scientist

Department of Neuroscience
University of Florids
1149 Newell Drive
PO Box 100244
Gainesville, FL  32611-0244

Email:  jer1984@ufl.edu
Lab Phone: (352) 294-8365

Key Words:  magnetic resonance microscopy, MRM, magnetic resonance imaging, MRI, ultra-high-field, cellular imaging, cellular MRI, acute, organotypic, live-slice, hippocampus, alpha-motor, neurotrauma, traumatic brain injury, TBI, alpha II-spectrin, calpain, caspase, necrosis, apoptosis

Education:

2009 Ph.D.
(Neuroscience)
University of Florida
Gainesville, FL
2009-2014 Postdoctoral Fellowship
(Neuroscience)
University of Florida
Gainesville, FL

Research Summary:

My current research focuses on developing MR techniques which enable measurement and visualization of tissue environments at the microscale. Such experiments require the interface of ultra-high field spectrometers capable of collecting images at isotropic resolutions less than or equal to10mm and MR-compatible superfusion equipment which can offer metabolic support to tissue explants. The magnet systems are made available through the National High Magnetic Field Laboratory’s (NHFML) Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS) facility. Equipment for the support of living acute and organotypic slice preparations is designed and fabricated in-house as part of my research activities.

Most recently, these techniques were used to investigate the diffusion signal changes elicited from pyramidal cells following exposure to the excitatory amino acid kainate. This interaction was studied for its potential role as a diffusion-signal based functional contrast mechanism akin to the blood-oxygen-level dependent (BOLD) based functional contrast. Future plans for microstructural studies on living tissues include visualizing individual mammalian cells and subcellular components using MR contrast as well as more nuanced functional studies employing optogenetic stimulation of neuronal populations.

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