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Jeremy C. McIntyre, Ph.D.

McIntyre, JeremyAssistant Professor

Department of Neuroscience
University of Florida
1149 Newell Drive
PO Box 100244
Gainesville, FL 32611-0244

Office Phone: (352) 294-8266
Lab Phone:     (352) 273-9018
Email:          jmcin@ufl.edu
Lab Website:  http://www.jmcintyrelab.org
Lab Members: McIntyre lab

Education:                          

2009 Ph.D. (Physiology) University of Kentucky, Lexington, KY
2009-2013 Postdoctoral Fellow (Pharmacology) University of Michigan, Ann Arbor, MI
2014-2015 Postdoctoral Associate (Pharmacology) University of Florida, Gainesville, FL

Key Words:  Olfaction, Anosmia, Channelopathy, Gene therapy, Neuronal cilia, neuromodulation, G-protein Coupled Receptors

Research Summary & Focus:
Areas of specialization include development, organization and function of the olfactory epithelium and the olfactory bulb. My lab makes use of several mouse genetic models for analysis of neuronal function in both of these tissues.

Broadly I am interested in the molecular mechanisms that underlie olfactory function. We are interested in applying gene therapy approaches to correct congential defects in the sense of smell. Additionally, we are interested in applying these techniques to improve and modulate olfactory function in healthy and aging individuals. Currently the lab is focused on mutations affecting ion channel function, but I am also interested in further investigating genetic causes of axonal growth defects in the olfactory system.

As part of this work, I am also interested in the trafficking of transmembrane proteins, including GPCRs into neuronal cilia. These organelles are critical for cellular function, and disruptions of cilia function can lead to numerous disease phenotypes. To further understand the role of neuronal cilia, we are investigating the contributions cilia play to regulating odor coding in the olfactory bulb.

To achieve these goals, we apply a wide range of techniques including immunofluorescence and Confocal microscopy, calcium imaging, electrophysiology, molecular biology and animal behavior.

 

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