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Eduardo Candelario-Jalil, Ph.D.

Eduardo Candelario-JalilAssistant Professor

Department of Neuroscience
University of Florida
1149 Newell Drive
PO Box 100244
Gainesville, FL 32611-0244

Email: ecandelario@ufl.edu
Office Phone: (352) 273-7116
Lab Phone:    (352) 273-6764
Lab Members:   Candelario-Jalil Lab

Education:

2002 Ph.D.
(Neuropharmacology)
University of Havana
Havana, Cuba
2003-2006 Postdoctoral Fellowship
(Molecular Neurobiology)
University of Freiburg Medical School
Germany
2006-2008 Postdoctoral Fellowship
(Neurology/Neuroscience)
University of Mexico
Albuquerque, NM

Key Words:    Ischemic Stroke; Neuroinflammation; Blood-Brain Barrier; Matrix Metalloproteinases; Cerebral Ischemia; Neurovascular Injury

Research Summary: 
Our research is aimed at understanding how neuroinflammation contributes to brain injury in ischemic stroke.

Research Focus & Aims:
The primary emphasis of our research is to understand the molecular mechanisms responsible for neuronal death in ischemic stroke. We are particularly interested in the blood-brain barrier (BBB) since neurovascular damage is a key neuropathological mechanism in stroke, which significantly contributes to brain edema, neurological deterioration, and death in stroke patients. We focus on the neuroinflammatory mechanisms following cerebral ischemia and specifically on the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway. These studies may lead to the identification of novel and much-needed therapeutic approaches to reduce the devastating consequences of stroke-induced blood-brain barrier damage.

 

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