David R. Borchelt, Ph.D.
Professor of Neuroscience
Director, SantaFe Health Alzheimer’s Disease Research Center;
Investigator, McKnight Brain Institute & CTRND
Office Phone: (352) 273-9664
Email: drb1@ufl.edu
Website: Borchelt Labortory
Recent or Most Significant Publications:
Prudencio M, Borchelt DR. Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states. Mol Neurodegener 2011; 6:77.PM:22094223
Tebbenkamp AT, Green C, Xu G, Denovan-Wright EM, Rising AC, Fromholt SE, Brown HH, Swing D, Mandel RJ, Tessarollo L, Borchelt DR. Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative. Hum Mol Genet 2011; 20(14):2770-2782.PM:21515588
Chen KA, Cruz PE, Lanuto DJ, Flotte TR, Borchelt DR, Srivastava A, Zhang J, Steindler DA, Zheng T. Cellular fusion for gene delivery to SCA1 affected Purkinje neurons. Mol Cell Neurosci 2011; 47(1):61-70.PM:21420496
Tebbenkamp AT, Swing D, Tessarollo L, Borchelt DR. Premature death and neurologic abnormalities in transgenic mice expressing a mutant huntingtin exon-2 fragment. Hum Mol Genet 2011; 20(8):1633-1642.PM:21307087
Lelie HL, Liba A, Bourassa MW, Chattopadhyay M, Chan PK, Gralla EB, Miller LM, Borchelt DR, Valentine JS, Whitelegge JP. Copper and zinc metallation status of copper-zinc superoxide dismutase from amyotrophic lateral sclerosis transgenic mice. J Biol Chem 2011; 286(4):2795-2806.PM:21068388
Liu Y, Lee MK, James MM, Price DL, Borchelt DR, Troncoso JC, Oh ES. Passive (amyloid-beta) immunotherapy attenuates monoaminergic axonal degeneration in the AbetaPPswe/PS1dE9 mice. J Alzheimers Dis 2011; 23(2):271-279.PM:20966549
Njie EG, Kantorovich S, Astary GW, Green C, Zheng T, Semple-Rowland SL, Steindler DA, Sarntinoranont M, Streit WJ, Borchelt DR. A preclinical assessment of neural stem cells as delivery vehicles for anti-amyloid therapeutics. PLoS One 2012; 7(3):e34097.PM:22496779
Prudencio M, Lelie H, Brown HH, Whitelegge JP, Valentine JS, Borchelt DR. A novel variant of human superoxide dismutase 1 harboring amyotrophic lateral sclerosis-associated and experimental mutations in metal-binding residues and free cysteines lacks toxicity in vivo. J Neurochem 2012; 121(3):475-485.PM:22332887
Njie EG, Boelen E, Stassen FR, Steinbusch HW, Borchelt DR, Streit WJ. Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function. Neurobiol Aging 2012; 33(1):195-12.PM:20580465
Roberts BL, Patel K, Brown HH, Borchelt DR. Role of disulfide cross-linking of mutant SOD1 in the formation of inclusion-body-like structures. PLoS One 2012; 7(10):e47838.PM:23118898
Shi Y, Mowery RA, Ashley J, Hentz M, Ramirez AJ, Bilgicer B, Slunt-Brown H, Borchelt DR, Shaw BF. Abnormal SDS-PAGE migration of cytosolic proteins can identify domains and mechanisms that control surfactant binding. Protein Sci 2012; 21(8):1197-1209.PM:22692797
Tebbenkamp AT, Crosby KW, Siemienski ZB, Brown HH, Golde TE, Borchelt DR. Analysis of Proteolytic Processes and Enzymatic Activities in the Generation of Huntingtin N-Terminal Fragments in an HEK293 Cell Model. PLoS One 2012; 7(12):e50750.PM:23236391
Xu G, Stevens SM, Jr., Kobiessy F, Brown H, McClung S, Gold MS, Borchelt DR. Identification of proteins sensitive to thermal stress in human neuroblastoma and glioma cell lines. PLoS One 2012; 7(11):e49021.PM:23145051
Xu G, Green CC, Fromholt SE, Borchelt DR. Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice. Alzheimers Res Ther 2012; 4(2):12.PM:22537779