Ashok Kumar, Ph.D.

Kumar-Ashok-5572Assistant Professor

Department of Neuroscience
University of Florida
1149 Newell Drive
PO Box 100244
Gainesville, FL 32611-0244

Email: kash@ufl.edu
Office:  (352) 392-4085
Lab: (352) 392-6863

Education: 

1992 Ph.D.
(Pharmacology)
University of Lucknow/Dentral Drug Research Institute
Lucknow, India
1992-1994 Postdoctoral Fellowship
(Pharmacology)
Central Drug Research Institute
Lucknow, India
1995-1997 Postdoctoral Fellowship
(Pharmacodynamics)
University of Illinois
Chicago, Illinois
1997-1999 Postdoctoral Fellowship
(Psychiatry)
Yale University
New Haven, Connecticut

Key Words:  Aging; Calcium; Hippocampus; Learning, Memory; Synaptic Plasticity; Cell excitability; Exercise; Environmental enrichment

Research Summary:

The overall goal of my research is to understand the mechanisms contributing to age-associated cognitive impairment and develop therapeutic innervations to rescue or reverse cognitive deficit associated with senescence.

Broadly, the overall goal of my research is to understand the relationship of brain aging and age-associated cognitive impairment and neurodegenerative diseases of aging. Towards this goal, my current research program is investigating how age-related augmented oxidative stress contribute to decrease in NMDA receptor function and its influence on hippocampal synaptic function and impaired cognitive performance. In addition to delineating role of NMDA receptor, my research also investigates influence of central and systemic inflammation on hippocampal-dependent spatial memory performance and synaptic transmission over the course of aging. We just completed an exciting study associated with DNS methylation during aging and its relationship with executive function, and results are submitted for the publication.

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