Dr. Joseph McQuail is a postdoctoral fellow in the laboratory of Dr. Jennifer Bizon. Joe has just received notification that he is being awarded an NIH F32 Fellowship Award on his project titled, “Molecular and physiological determinants of age-related working memory decline”. Congratulations, Joe. A well-deserved honor! You have…
Contribution of N-methyl-D-aspartate receptors to attention and episodic spatial memory during senescence. Guidi M, Rani A, Karic S, Severance B, Kumar A, Foster TC. Neurobiol Learn Mem 2015. Abstract: A decrease in N-methyl-D-aspartate receptor (NMDAR) function is associated with age-related cognitive impairments. However, NMDAR antagonists are prescribed…
DNA Methylation in Basal Metazoans: Insights from Ctenophores. Dabe EC, Sanford RS, Kohn AB, Bobkova Y, Moroz LL. Integr Comp Biol 2015. Abstract: Epigenetic modifications control gene expression without altering the primary DNA sequence. However, little is known about DNA methylation in invertebrates and its evolution. Here,…
Cholestenoic acid, an endogenous cholesterol metabolite, is a potent gamma-secretase modulator. Jung JI, Price AR, Ladd TB, Ran Y, Park HJ, Ceballos-Diaz C, Smithson LA, Hochhaus G, Tang Y, Akula R, Ba S, Koo EH, Shapiro G, Felsenstein KM, Golde TE. Mol Neurodegener 2015; 10(1):29. Abstract:…
Biodiversity Meets Neuroscience: From the Sequencing Ship (Ship-Seq) to Deciphering Parallel Evolution of Neural Systems in Omic’s Era. Moroz LL. Integr Comp Biol 2015. Abstract: The origins of neural systems and centralized brains are one of the major transitions in evolution. These events might occur more than…
Please join us in congratulating Dr. Kaustuv Saha and Danielle Sambo for receiving fellowships from the McKnight Brain Institute. The MBI Fellowships were established to support students and fellows conducting neuroscience and brain-related research in MBI affiliated laboratories. Two winners were selected and will each receive $60,000 ($30,000/year for two…
IFN-gamma promotes tau phosphorylation without affecting mature tangles. Li A, Ceballos-Diaz C, DiNunno N, Levites Y, Cruz PE, Lewis J, Golde TE, Chakrabarty P. FASEB J 2015. Abstract: Inflammatory activation precedes and correlates with accumulating τ lesions in Alzheimer’s disease and tauopathies. However, the relationship between neuroinflammation…
Studies of alternative isoforms provide insight into TDP-43 autoregulation and pathogenesis. D’Alton S, Altshuler M, Lewis J. RNA 2015. Abstract: TDP-43 is a soluble, nuclear protein that undergoes cytoplasmic redistribution and aggregation in the majority of cases of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 autoregulates…
Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2. Hamm M, Bailey R, Shaw G, Yen SH, Lewis J, Giasson BI. J Neurosci Res 2015. Abstract: Hyperphosphorylation and aggregation of tau are observed in multiple neurodegenerative diseases termed tauopathies. Tau has also been implicated in…
